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Direct mitochondrial import of lactate supports resilient carbohydrate oxidation.

Autor: Cluntun AA; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Visker JR; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA., Velasco-Silva JN; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Lang MJ; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.; The Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA., Cedeño-Rosario L; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Shankar TS; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA., Hamouche R; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA., Ling J; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA., Kim JE; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Toshniwal AG; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Low HK; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Cunningham CN; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Carrington J; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Catrow JL; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.; Metabolomics, Proteomics and Mass Spectrometry Core Facility, University of Utah, Salt Lake City, UT 84112, USA., Pearce Q; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.; Metabolomics, Proteomics and Mass Spectrometry Core Facility, University of Utah, Salt Lake City, UT 84112, USA., Jeong MY; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Bott AJ; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Narbona-Pérez ÁJ; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Stanley CE; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Li Q; High-throughput Genomics Core, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA., Eberhardt DR; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA., Morgan JT; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Yadav T; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Wells CE; University of Utah, Department of Pathology, Salt Lake City, UT 84112, USA., Ramadurai DKA; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA., Swiatek WI; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Chaudhuri D; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.; Division of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84112, USA.; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA., Rothstein JD; Department of Neurology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA., Muoio DM; Departments of Medicine and Pharmacology and Cancer Biology, and Duke Molecular Physiology Institute, Duke University, Durham, NC, USA., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Baker SA; University of Utah, Department of Pathology, Salt Lake City, UT 84112, USA., Navankasattusas S; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA., Cox JE; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.; Metabolomics, Proteomics and Mass Spectrometry Core Facility, University of Utah, Salt Lake City, UT 84112, USA., Funai K; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.; The Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA., Drakos SG; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.; Division of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84112, USA.; U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Healthcare and School of Medicine, Intermountain Medical Center, Salt Lake VA (Veterans Affairs) Health Care System, Salt Lake City, UT, USA., Rutter J; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.; Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA., Ducker GS; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 08. Date of Electronic Publication: 2024 Oct 08.