Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Swetha K. Godavarthi"'
Autor:
Marta Pratelli, Anna M. Hakimi, Arth Thaker, Hyeonseok Jang, Hui-quan Li, Swetha K. Godavarthi, Byung Kook Lim, Nicholas C. Spitzer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cognitive deficits are long-lasting consequences of drug use, yet the convergent mechanism by which classes of drugs with different pharmacological properties cause similar deficits is unclear. We find that both phencyclidine and methampheta
Externí odkaz:
https://doaj.org/article/ae571b8360e04b54843811fe5c4dadab
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 1, Pp 26-34 (2009)
The UBE3A/E6-AP is known to function both as an E3 ubiquitin ligase of the ubiquitin proteasome system and as a transcriptional coactivator. E6-AP shows brain-specific imprinting and loss of function of maternally inherited E6-AP causes Angelman synd
Externí odkaz:
https://doaj.org/article/07dff4518a214a9b98aabc495657e3a9
Autor:
Hui-quan Li, Wuji Jiang, Lily Ling, Vaidehi Gupta, Cong Chen, Marta Pratelli, Swetha K. Godavarthi, Nicholas C. Spitzer
Overgeneralization of fear to harmless situations is a core feature of anxiety disorders resulting from acute stress, yet the mechanisms by which fear becomes generalized are poorly understood. Here we show that generalized fear in mice in response t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edd6bb86d53f072d81c9429e8871d424
https://doi.org/10.1101/2023.05.10.540268
https://doi.org/10.1101/2023.05.10.540268
Autor:
Swetha K. Godavarthi, Masaki Hiramoto, Yuri Ignatyev, Jacqueline B. Levin, Hui-quan Li, Marta Pratelli, Jennifer Borchardt, Cynthia Czajkowski, Laura N. Borodinsky, Lora Sweeney, Hollis T. Cline, Nicholas C. Spitzer
Stable matching of neurotransmitters with their receptors is fundamental to synapse function, to achieve reliable and robust communication in neural circuits. Presynaptic neurotransmitters regulate selection of postsynaptic transmitter receptors. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20a3f9e8b7b6963e329b3a373fb2477f
https://doi.org/10.1101/2022.09.10.507343
https://doi.org/10.1101/2022.09.10.507343
Publikováno v:
J Neurosci
Neurotransmitter switching is a form of brain plasticity in which an environmental stimulus causes neurons to replace one neurotransmitter with another, often resulting in changes in behavior. This raises the possibility of applying a specific enviro
Publikováno v:
Biochemical and Biophysical Research Communications. 464:1196-1201
Angelman syndrome (AS) is a neurodevelopmental disorder characterized by severe cognitive and motor deficits, caused by the loss of function of maternally inherited Ube3a. Ube3a-maternal deficient mice (AS model mice) recapitulate many essential feat
Publikováno v:
Human Molecular Genetics. 21:1824-1834
Angelman syndrome (AS) is a neurodevelopmental disorder caused due to deletions or loss-of-function mutations in maternally inherited UBE3A. Ube3a functions as an ubiquitin ligase as well as a transcriptional coactivator of steroid hormone receptors.
Publikováno v:
Journal of Biological Chemistry. 284:10537-10545
Cells are equipped with an efficient quality control system to selectively eliminate abnormally folded and damaged proteins. Initially the cell tries to refold the unfolded proteins with the help of molecular chaperones, and failure to refold leads t
Autor:
Anand Goswami, Nihar Ranjan Jana, Sudheendra N.R. Rao, Nobuyuki Nukina, Amit Mishra, Doronala Narender, Swetha K. Godavarthi
Publikováno v:
Journal of Neurochemistry. 108:787-795
Huntington's disease is a hereditary neurodegenerative disorder caused by an aberrant polyglutamine expansion in the amino terminus of the huntingtin protein. The resultant mutant huntingtin form aggregates in neurons and causes neuronal dysfunction
Publikováno v:
Journal of neurochemistry. 130(3)
Angelman syndrome (AS) is a neuropsychiatric disorder characterized by autism, intellectual disability and motor disturbances. The disease is primarily caused by the loss of function of maternally inherited UBE3A. Ube3a maternal-deficient mice recapi