A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation

Autor: Claudia Firrito, Cinzia Bertelli, Annachiara Rosa, Ajit Chande, Swetha Ananth, Hannah van Dijk, Oliver T. Fackler, Charlotte Stoneham, Rajendra Singh, John Guatelli, Massimo Pizzato

Publikováno v: Viruses, Vol 15, Iss 3, p 652 (2023)

The host transmembrane protein SERINC5 is incorporated into retrovirus particles and inhibits HIV-1 infectivity. The lentiviral Nef protein counteracts SERINC5 by downregulating it from the cell surface and preventing its incorporation into virions.

Externí odkaz: https://doaj.org/article/a5b68f8f594a4f6e9f4e1048f10584e8

HIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function

Autor: Katharina Morath, Florian Klein, Sheetal Kaw, Bahar M Coban, Oliver T. Fackler, Ralph Hohenberger, Olcay Cem Bulut, Bettina Stolp, Swetha Ananth, Nikolaos Tsopoulidis

Publikováno v: The EMBO Journal

Failures to produce neutralizing antibodies upon HIV‐1 infection result in part from B‐cell dysfunction due to unspecific B‐cell activation. How HIV‐1 affects antigen‐specific B‐cell functions remains elusive. Using an adoptive transfer m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9494197cdd4802c5540227ce0f5e82c
http://europepmc.org/articles/PMC7737609

Multifunctional Roles of the N-Terminal Region of HIV-1 SF2 Nef Are Mediated by Three Independent Protein Interaction Sites

Autor: Oliver T. Fackler, Nadine Tibroni, Bettina Stolp, Benedikt Obermaier, Swetha Ananth, Iart Luca Shytaj, Katharina Morath, Marina Lusic, Birthe Trautz

Publikováno v: Journal of Virology. 94

HIV-1 Nef promotes virus spread and disease progression by altering host cell transport and signaling processes through interaction with multiple host cell proteins. The N-terminal region in HIV-1 Nef encompassing residues 12 to 39 has been implicate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::674c2e3a330185d63395363cb153f677
https://doi.org/10.1128/jvi.01398-19

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue

Autor: Frank Kirchhoff, Dominik Hotter, Daniel Sauter, Martine Peeters, Christine Goffinet, Oliver T. Fackler, Konstantin M. J. Sparrer, Zhong Yao, Birthe Trautz, Ahidjo Ayouba, Bengisu Akbil, Thomas Zillinger, Igor Stagljar, Christina M. Stürzel, Swetha Ananth, Vânia Passos, Dorota Kmiec

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2018, 14 (8), pp.e1007269. ⟨10.1371/journal.ppat.1007269⟩
PLoS Pathogens, 2018, 14 (8), pp.e1007269. ⟨10.1371/journal.ppat.1007269⟩
PLoS Pathogens, Vol 14, Iss 8, p e1007269 (2018)

SERINC5 is a host restriction factor that impairs infectivity of HIV-1 and other primate lentiviruses and is counteracted by the viral accessory protein Nef. However, the importance of SERINC5 antagonism for viral replication and cytopathicity remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b72fbdfa61b16dcbef54db92a37758
https://www.hal.inserm.fr/inserm-02169906