Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Swetansu Pattnaik"'
Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer
Autor:
Elizabeth L. Christie, Swetansu Pattnaik, Jessica Beach, Anthony Copeland, Nineveh Rashoo, Sian Fereday, Joy Hendley, Kathryn Alsop, Samuel L. Brady, Greg Lamb, Ahwan Pandey, Anna deFazio, Heather Thorne, Andrea Bild, David D. L. Bowtell
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
ABCB1 encodes Multidrug Resistance Protein which promotes efflux of chemotherapeutic and targeted agents. Here, in breast and ovarian cancer the authors identify multiple transcriptional fusion partners involving ABCB1 that are associated with treatm
Externí odkaz:
https://doaj.org/article/3d60dcd89a874c7d9dd75f1ea6c6ed3b
Autor:
Neeraja Krishnan, Saurabh Gupta, Vinayak Palve, Linu Varghese, Swetansu Pattnaik, Prach Jain, Costerwell Khyriem, Arun Hariharan, Kunal Dhas, Jayalakshmi Nair, Manisha Pareek, Venkatesh Prasad, Gangotri Siddappa, Amritha Suresh, Vikram Kekatpure, Moni Kuriakose, Binay Panda
Publikováno v:
F1000Research, Vol 4 (2015)
Oral tongue squamous cell carcinomas (OTSCC) are a homogeneous group of tumors characterized by aggressive behavior, early spread to lymph nodes and a higher rate of regional failure. Additionally, the incidence of OTSCC among younger population (
Externí odkaz:
https://doaj.org/article/52f40054fe11491691c55ebfb1d4a470
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30080 (2012)
The advent of next generation sequencing (NGS) technologies have revolutionised the way biologists produce, analyse and interpret data. Although NGS platforms provide a cost-effective way to discover genome-wide variants from a single experiment, var
Externí odkaz:
https://doaj.org/article/de43b0e002424789ae21107101f94f3b
Autor:
Christopher N. Hahn, Sarah Moore, Simone Feurstein, Devendra K Hiwase, Jinghua Feng, Swetansu Pattnaik, Deepak Singhal, Leila Eshraghi, Richard J D'Andrea, Li Yan A Wee, Hamish S. Scott, Monika M Kutyna, Anna L. Brown, Milena Babic, Paul Ps Wang, Andreas W. Schreiber, David Thomas, Wendy T Parker, Luke D Moma, Lucy A. Godley, Song Gao, Rakchha Chhetri, Soma Das, Daniel Thomas, Nicola K. Poplawski
The majority of studies assessing the contribution of pathogenic germline variants (PGVs) to cancer predisposition have focused on patients with single cancers. We analyzed 45 known cancer predisposition genes (CPGs) in germline samples of 202 patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ecc856cdce965fb041a03d4e55c4b18
https://hdl.handle.net/11541.2/147074
https://hdl.handle.net/11541.2/147074
Autor:
Deepak, Singhal, Christopher N, Hahn, Simone, Feurstein, Li Yan A, Wee, Luke, Moma, Monika M, Kutyna, Rakchha, Chhetri, Leila, Eshraghi, Andreas W, Schreiber, Jinghua, Feng, Paul P-S, Wang, Milena, Babic, Wendy T, Parker, Song, Gao, Sarah, Moore, Soma, Das, David, Thomas, Swetansu, Pattnaik, Anna L, Brown, Richard J, D'Andrea, Nicola K, Poplawski, Daniel, Thomas, Hamish S, Scott, Lucy A, Godley, Devendra K, Hiwase
Publikováno v:
Leukemia. 35(11)
The majority of studies assessing the contribution of pathogenic germline variants (PGVs) to cancer predisposition have focused on patients with single cancers. We analyzed 45 known cancer predisposition genes (CPGs) in germline samples of 202 patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15d6c6477281b93d5be924b73029154e
https://pubmed.ncbi.nlm.nih.gov/33850299
https://pubmed.ncbi.nlm.nih.gov/33850299
Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer
Autor:
Greg Lamb, Anna deFazio, Joy Hendley, Jessica A. Beach, Heather Thorne, Kathryn Alsop, Sian Fereday, Elizabeth L. Christie, Anthony Copeland, Andrea H. Bild, Nineveh Rashoo, Samuel L. Brady, David D.L. Bowtell, Ahwan Pandey, Swetansu Pattnaik
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
ABCB1 encodes Multidrug Resistance protein (MDR1), an ATP-binding cassette member involved in the cellular efflux of chemotherapeutic drugs. Here we report that ovarian and breast samples from chemotherapy treated patients are positive for multiple t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081bb8663728e2967e24393ea5ae8f97
https://doi.org/10.1038/s41467-019-09312-9
https://doi.org/10.1038/s41467-019-09312-9
The grouping of cancers across tissue boundaries is central to precision oncology, but remains a difficult problem. Here we present EPICC (Experimental Protein Interaction Clustering of Cancer), a novel technique to cluster cancer patients based on D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695349c9fefb09bc9880c835a431e0c9
https://doi.org/10.1101/432872
https://doi.org/10.1101/432872
Autor:
Alex Miranda, Aurélien de Reyniès, Etienne Becht, Swetansu Pattnaik, Phineas T. Hamilton, Patrick Micke, Brad H. Nelson, Jarle Bruun, Artur Mezheyeuski, Allen W. Zhang
SummaryRegulatory programs that control the function of stem cells are active in cancer and confer properties that promote progression and therapy resistance. However, the impact of a stem cell-like tumor phenotype (“sternness”) on the immunologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4668308515d282b5dca46bd467bcd050
https://doi.org/10.1101/352559
https://doi.org/10.1101/352559
Autor:
Sarah-Jane Dawson, Ken Doig, Swetansu Pattnaik, Sian Fereday, David D.L. Bowtell, Elizabeth L. Christie
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 35(12)
Purpose Germline BRCA1 or BRCA2 mutations in patients with high-grade serous ovarian cancer (HGSC) are associated with favorable responses to chemotherapy. However, secondary intragenic (reversion) mutations that restore protein function lead to clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e09a00c39ab47352bf8986db5071fdd
https://pubmed.ncbi.nlm.nih.gov/28414925
https://pubmed.ncbi.nlm.nih.gov/28414925
Autor:
Swetansu Pattnaik, Samuel W. Brady, Dariush Etemadmoghadam, Dale W. Garsed, Jessica A. Beach, Andrea Bild, Sian Fereday, Ann-Marie Patch, Elizabeth L. Christie, David D.L. Bowtell
Publikováno v:
Clinical Cancer Research. 24:IA12-IA12
High-grade serous ovarian cancer (HGSC) was one of the first cancer types subjected to comprehensive genomic analysis, and over the last 5-7 years gene expression and DNA sequence data have been generated from hundreds of samples. A large majority of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46084c271683f9a7c905a5f36a6cea30
https://doi.org/10.1158/1557-3265.ovca17-ia12
https://doi.org/10.1158/1557-3265.ovca17-ia12