Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sweta, Parik"'
Autor:
Sweta Parik, Juan Fernández-García, Francesca Lodi, Karen De Vlaminck, Marleen Derweduwe, Steven De Vleeschouwer, Raf Sciot, Wietse Geens, Linqian Weng, Francesca Maria Bosisio, Gabriele Bergers, Johnny Duerinck, Frederick De Smet, Diether Lambrechts, Jo A. Van Ginderachter, Sarah-Maria Fendt
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastoma is a highly lethal grade of astrocytoma with very low median survival. Despite extensive efforts, there is still a lack of alternatives that might improve these prospects. We uncovered that the chemotherapeutic agent temozolomide impinge
Externí odkaz:
https://doaj.org/article/9b367757c6e54473af57787cad0920a8
Autor:
Pu-Ste Liu, Yi-Ting Chen, Xiaoyun Li, Pei-Chun Hsueh, Sheue-Fen Tzeng, Hsi Chen, Pei-Zhu Shi, Xin Xie, Sweta Parik, Mélanie Planque, Sarah-Maria Fendt, Ping-Chih Ho
Publikováno v:
Nature Immunology. 24:452-462
Exposure of lipopolysaccharide triggers macrophage pro-inflammatory polarization accompanied by metabolic reprogramming, characterized by elevated aerobic glycolysis and a broken tricarboxylic acid cycle. However, in contrast to lipopolysaccharide, C
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Metastasis formation is the leading cause of death in cancer patients. Thus, understanding and targeting this process is an unmet need. Crucial steps during the establishment of metastases include the (pre)metastatic niche formation. This process rel
Externí odkaz:
https://doaj.org/article/f62c615d406c457cba87bd396c4ce25e
Autor:
Matteo Rossi, Patricia Altea-Manzano, Margherita Demicco, Ginevra Doglioni, Laura Bornes, Marina Fukano, Anke Vandekeere, Alejandro M. Cuadros, Juan Fernández-García, Carla Riera-Domingo, Cristina Jauset, Mélanie Planque, H. Furkan Alkan, David Nittner, Dongmei Zuo, Lindsay A. Broadfield, Sweta Parik, Antonino Alejandro Pane, Francesca Rizzollo, Gianmarco Rinaldi, Tao Zhang, Shao Thing Teoh, Arin B. Aurora, Panagiotis Karras, Ines Vermeire, Dorien Broekaert, Joke Van Elsen, Maximilian M. L. Knott, Martin F. Orth, Sofie Demeyer, Guy Eelen, Lacey E. Dobrolecki, Ayse Bassez, Thomas Van Brussel, Karl Sotlar, Michael T. Lewis, Harald Bartsch, Manfred Wuhrer, Peter van Veelen, Peter Carmeliet, Jan Cools, Sean J. Morrison, Jean-Christophe Marine, Diether Lambrechts, Massimiliano Mazzone, Gregory J. Hannon, Sophia Y. Lunt, Thomas G. P. Grünewald, Morag Park, Jacco van Rheenen, Sarah-Maria Fendt
Publikováno v:
Nature
Rossi, M, Altea-Manzano, P, Demicco, M, Doglioni, G, Bornes, L, Fukano, M, Vandekeere, A, Cuadros, A M, Fernández-García, J, Riera-Domingo, C, Jauset, C, Planque, M, Alkan, H F, Nittner, D, Zuo, D, Broadfield, L A, Parik, S, Pane, A A, Rizzollo, F, Rinaldi, G, Zhang, T, Teoh, S T, Aurora, A B, Karras, P, Vermeire, I, Broekaert, D, Elsen, J V, Knott, M M L, Orth, M F, Demeyer, S, Eelen, G, Dobrolecki, L E, Bassez, A, Brussel, T V, Sotlar, K, Lewis, M T, Bartsch, H, Wuhrer, M, Veelen, P V, Carmeliet, P, Cools, J, Morrison, S J, Marine, J C, Lambrechts, D, Mazzone, M, Hannon, G J, Lunt, S Y, Grünewald, T G P, Park, M, Rheenen, J V & Fendt, S M 2022, ' PHGDH heterogeneity potentiates cancer cell dissemination and metastasis ', Nature, vol. 605, no. 7911, pp. 747-753 . https://doi.org/10.1038/s41586-022-04758-2
Nature, 605(7911), 747-+. NATURE PORTFOLIO
Rossi, M, Altea-Manzano, P, Demicco, M, Doglioni, G, Bornes, L, Fukano, M, Vandekeere, A, Cuadros, A M, Fernández-García, J, Riera-Domingo, C, Jauset, C, Planque, M, Alkan, H F, Nittner, D, Zuo, D, Broadfield, L A, Parik, S, Pane, A A, Rizzollo, F, Rinaldi, G, Zhang, T, Teoh, S T, Aurora, A B, Karras, P, Vermeire, I, Broekaert, D, Elsen, J V, Knott, M M L, Orth, M F, Demeyer, S, Eelen, G, Dobrolecki, L E, Bassez, A, Brussel, T V, Sotlar, K, Lewis, M T, Bartsch, H, Wuhrer, M, Veelen, P V, Carmeliet, P, Cools, J, Morrison, S J, Marine, J C, Lambrechts, D, Mazzone, M, Hannon, G J, Lunt, S Y, Grünewald, T G P, Park, M, Rheenen, J V & Fendt, S M 2022, ' PHGDH heterogeneity potentiates cancer cell dissemination and metastasis ', Nature, vol. 605, no. 7911, pp. 747-753 . https://doi.org/10.1038/s41586-022-04758-2
Nature, 605(7911), 747-+. NATURE PORTFOLIO
Cancer metastasis requires the transient activation of cellular programs enabling dissemination and seeding in distant organs1. Genetic, transcriptional and translational heterogeneity contributes to this dynamic process2,3. Metabolic heterogeneity h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e5caca229c7c7298416a476ab4cc79
https://hdl.handle.net/1887/3480405
https://hdl.handle.net/1887/3480405
Autor:
Juan Fernández-García, Fabien Franco, Sweta Parik, Patricia Altea-Manzano, Antonino Alejandro Pane, Dorien Broekaert, Joke van Elsen, Giusy Di Conza, Ines Vermeire, Tessa Schalley, Mélanie Planque, Thomas van Brussel, Rogier Schepers, Elodie Modave, Tobias K. Karakach, Peter Carmeliet, Diether Lambrechts, Ping-Chih Ho, Sarah-Maria Fendt
Publikováno v:
Cell Reports
Fernández-García, J, Franco, F, Parik, S, Altea-Manzano, P, Pane, A A, Broekaert, D, van Elsen, J, Vermeire, I, Schalley, T, Planque, M, van Brussel, T, Schepers, R, Modave, E, Karakach, T K, Carmeliet, P, Lambrechts, D, Ho, P C & Fendt, S M 2022, ' CD8 + T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation ', Cell Reports, vol. 41, no. 7, 111639 . https://doi.org/10.1016/j.celrep.2022.111639
Fernández-García, J, Franco, F, Parik, S, Altea-Manzano, P, Pane, A A, Broekaert, D, van Elsen, J, Vermeire, I, Schalley, T, Planque, M, van Brussel, T, Schepers, R, Modave, E, Karakach, T K, Carmeliet, P, Lambrechts, D, Ho, P C & Fendt, S M 2022, ' CD8 + T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation ', Cell Reports, vol. 41, no. 7, 111639 . https://doi.org/10.1016/j.celrep.2022.111639
T cells dynamically rewire their metabolism during an immune response. We applied single-cell RNA sequencing to CD8+ T cells activated and differentiated in vitro in physiological medium to resolve these metabolic dynamics. We identify a differential
Autor:
Matteo Rossi, Patricia Altea-Manzano, Margherita Demicco, Ginevra Doglioni, Laura Bornes, Marina Fukano, Anke Vandekeere, Alejandro M. Cuadros, Juan Fernández-García, Carla Riera-Domingo, Cristina Jauset, Mélanie Planque, H. Furkan Alkan, David Nittner, Dongmei Zuo, Lindsay A. Broadfield, Sweta Parik, Antonino Alejandro Pane, Francesca Rizzollo, Gianmarco Rinaldi, Tao Zhang, Shao Thing Teoh, Arin B. Aurora, Panagiotis Karras, Ines Vermeire, Dorien Broekaert, Joke Van Elsen, Maximilian M. L. Knott, Martin F. Orth, Sofie Demeyer, Guy Eelen, Lacey E. Dobrolecki, Ayse Bassez, Thomas Van Brussel, Karl Sotlar, Michael T. Lewis, Harald Bartsch, Manfred Wuhrer, Peter van Veelen, Peter Carmeliet, Jan Cools, Sean J. Morrison, Jean-Christophe Marine, Diether Lambrechts, Massimiliano Mazzone, Gregory J. Hannon, Sophia Y. Lunt, Thomas G. P. Grünewald, Morag Park, Jacco van Rheenen, Sarah-Maria Fendt
Publikováno v:
Nature. 609:E8-E8
Autor:
Juan, Fernández-García, Fabien, Franco, Sweta, Parik, Patricia, Altea-Manzano, Antonino Alejandro, Pane, Dorien, Broekaert, Joke, van Elsen, Ines, Vermeire, Tessa, Schalley, Mélanie, Planque, Thomas, van Brussel, Rogier, Schepers, Elodie, Modave, Tobias K, Karakach, Peter, Carmeliet, Diether, Lambrechts, Ping-Chih, Ho, Sarah-Maria, Fendt
Publikováno v:
Cell reports. 41(7)
T cells dynamically rewire their metabolism during an immune response. We applied single-cell RNA sequencing to CD8
Autor:
Sarah-Maria Fendt, Peter Carmeliet, Rogier Schepers, Sweta Parik, Antonino Alejandro Pane, Juan Fernández-García, Fabien Franco, Tobias K. Karakach, Ping-Chih Ho, Dorien Broekaert, Joke Van Elsen, Ines Vermeire, Elodie Modave, Thomas Van Brussel, Diether Lambrechts
Cytotoxic T cells dynamically rewire their metabolism during the course of an immune response. While T-cell metabolism has been extensively studied at phenotypic endpoints of activation and differentiation, the underlying dynamics remain largely elus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e81551b208900057b3f8feb8cdf0f083
https://doi.org/10.1101/2021.07.27.453976
https://doi.org/10.1101/2021.07.27.453976
Autor:
Sebastian Munck, Kazuaki Yoshinaga, Mariia Yuneva, Gianmarco Rinaldi, Kwok-Kin Wong, Juan Fernández-García, Brandon Faubert, Chris Verslype, Thomas G. P. Grunewald, Sweta Parik, Mustapha Najimi, Catherine M. Verfaillie, Carmen Escalona-Noguero, Leanne Hodson, Kim Vriens, Sylvia Grünewald, Stefan Christen, Charlotte Kopitz, Catriona Charlton, Andrés Méndez-Lucas, Axelle Kerstens, Naohiro Gotoh, Matteo Rossi, Johannes V. Swinnen, David Cassiman, Arndt Schmitz, Laura Beretta, Ting Chen, Ruben Boon, Etienne Sokal, Patrick Steigemann, Andrea Hägebarth, Jonas Dehairs, Roberta Schmieder, Thomas Cornfield, Dorien Broekaert, Sarah-Maria Fendt, Jo A. Van Ginderachter, Martin F. Orth, Suet Ying Kwan, Laura Romero-Pérez, Sven Christian, Ali Talebi, Rita Derua, Ralph J. DeBerardinis, Joao A.G. Duarte
Publikováno v:
Nature
Most tumours have an aberrantly activated lipid metabolism1,2 that enables them to synthesize, elongate and desaturate fatty acids to support proliferation. However, only particular subsets of cancer cells are sensitive to approaches that target fatt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4fabf9bd4ddc36b2d7b181be546e8e
https://doi.org/10.1038/s41586-019-0904-1
https://doi.org/10.1038/s41586-019-0904-1
SummaryMitochondrial mechanisms and pathways have recently emerged as critical determinants of organismal aging. While nuclear sirtuins have been shown to regulate aging, whether mitochondrial sirtuins do so is still unclear. Here, we report that mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d085052ff76e6a7f67a950541be4d700