Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Swerdlow, DI"'
Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis
Autor:
Harrison, SC, Holmes, MV, Burgess, S, Asselbergs, FW, Jones, GT, Baas, AF, Van 'T Hof, FN, De Bakker, PIW, Blankensteijn, JD, Powell, JT, Saratzis, A, De Borst, GJ, Swerdlow, DI, Van Der Graaf, Y, Van Rij, AM, Carey, DJ, Elmore, JR, Tromp, G, Kuivaniemi, H, Sayers, RD, Samani, NJ, Bown, MJ, Humphries, SE
Publikováno v:
JAMA Cardiology, 3(1), 26. American Medical Association
JAMA cardiology, 3(1), 26-33. American Medical Association
Harrison, S C, Holmes, M V, Burgess, S, Asselbergs, F W, Jones, G T, Baas, A F, van 't Hof, F N, de Bakker, P I W, Blankensteijn, J D, Powell, J T, Saratzis, A, de Borst, G J, Swerdlow, D I, van der Graaf, Y, van Rij, A M, Carey, D J, Elmore, J R, Tromp, G, Kuivaniemi, H, Sayers, R D, Samani, N J, Bown, M J & Humphries, S E 2018, ' Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm : A Meta-analysis ', JAMA cardiology, vol. 3, no. 1, pp. 26-33 . https://doi.org/10.1001/jamacardio.2017.4293
JAMA Cardiol
JAMA cardiology, 3(1), 26-33. American Medical Association
Harrison, S C, Holmes, M V, Burgess, S, Asselbergs, F W, Jones, G T, Baas, A F, van 't Hof, F N, de Bakker, P I W, Blankensteijn, J D, Powell, J T, Saratzis, A, de Borst, G J, Swerdlow, D I, van der Graaf, Y, van Rij, A M, Carey, D J, Elmore, J R, Tromp, G, Kuivaniemi, H, Sayers, R D, Samani, N J, Bown, M J & Humphries, S E 2018, ' Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm : A Meta-analysis ', JAMA cardiology, vol. 3, no. 1, pp. 26-33 . https://doi.org/10.1001/jamacardio.2017.4293
JAMA Cardiol
Importance: Risk factors for abdominal aortic aneurysm (AAA) are largely unknown, which has hampered the development of nonsurgical treatments to alter the natural history of disease. Objective: To investigate the association between lipid-associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30b55afa0835c73b746a0d253f0e2ea
https://www.repository.cam.ac.uk/handle/1810/275511
https://www.repository.cam.ac.uk/handle/1810/275511
Publikováno v:
Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium
Notable heterogeneity exists in the clinical presentation of heart failure (HF) patients. Current subtype classifications are based on ejection fraction may not fully capture the aetiological and prognostic heterogeneity of HF. The use of unsupervise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::6a20b220e0f022cd16397be546e9f81e
http://hdl.handle.net/10044/1/71095
http://hdl.handle.net/10044/1/71095
Autor:
McLachlan, S, Giambartolomei, C, White, J, Charoen, P, Wong, A, Finan, C, Engmann, J, Shah, T, Hersch, M, Podmore, C, Cavadino, A, Jefferis, BJ, Dale, CE, Hypponen, E, Morris, RW, Casas, JP, Kumari, M, Ben-Shlomo, Y, Gaunt, TR, Drenos, F, Langenberg, C, Kuh, D, Kivimaki, M, Rueedi, R, Waeber, G, Hingorani, AD, Price, JF, Walker, AP, Cooper, J, Day, IN, De Silva, M, Dudbridge, F, Fatemifar, G, Garfield, V, Humphries, SE, Lawlor, DA, Davies, TL, Plagnol, V, Power, C, Shah, S, Sofat, R, Swerdlow, DI, Talmud, PJ, Whincup, P, Whittaker, JC, Zabaneh, D
Red blood cell (RBC) traits are routinely measured in clinical practice as important markers of health. Deviations from the physiological ranges are usually a sign of disease, although variation between healthy individuals also occurs, at least partl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cad0cbc1e7238547dbba468ed08fd13f
http://bura.brunel.ac.uk/handle/2438/18985
http://bura.brunel.ac.uk/handle/2438/18985
Autor:
White, J, Sofat, R, Hemani, G, Shah, T, Engmann, J, Dale, C, Shah, S, Kruger, FA, Giambartolomei, C, Swerdlow, DI, Palmer, T, McLachlan, S, Langenberg, C, Zabaneh, D, Lovering, R, Cavadino, A, Jefferis, B, Finan, C, Wong, A, Amuzu, A, Ong, K, Gaunt, TR, Warren, H, Davies, TL, Drenos, F, Cooper, J, Ebrahim, S, Lawlor, DA, Talmud, PJ, Humphries, SE, Power, C, Hypponen, E, Richards, M, Hardy, R, Kuh, D, Wareham, N, Ben-Shlomo, Y, Day, IN, Whincup, P, Morris, R, Strachan, MW, Price, J, Kumari, M, Kivimaki, M, Plagnol, V, Whittaker, JC, International Consortium for Blood Pressure (ICBP), Smith, GD, Dudbridge, F, Casas, JP, Holmes, MV, Hingorani, AD, UCLEB (University College London-London School of Hygiene & Trop
BACKGROUND: Increased circulating plasma urate concentration is associated with an increased risk of coronary heart disease, but the extent of any causative effect of urate on risk of coronary heart disease is still unclear. In this study, we aimed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::854b036b1918cc597de4a7124472857e
https://researchonline.lshtm.ac.uk/id/eprint/2537075/1/mmc1.pdf
https://researchonline.lshtm.ac.uk/id/eprint/2537075/1/mmc1.pdf
Autor:
Swerdlow, DI, Preiss, D, Kuchenbaecker, KB, Holmes, MV, Engmann, JEL, Shah, T, Sofat, R, Stender, S, Johnson, PCD, Scott, RA, Leusink, M, Verweij, N, Sharp, SJ, Guo, Y, Giambartolomei, C, Chung, C, Peasey, A, Amuzu, A, Li, K, Palmen, J, Howard, P, Cooper, JA, Drenos, F, Li, YR, Lowe, G, Gallacher, J, Stewart, MCW, Tzoulaki, I, Buxbaum, SG, Van Der A, DL, Forouhi, NG, Onland-Moret, NC, Van Der Schouw, YT, Schnabel, RB, Hubacek, JA, Kubinova, R, Baceviciene, M, Tamosiunas, A, Pajak, A, Topor-Madry, R, Stepaniak, U, Malyutina, S, Baldassarre, D, Sennblad, B, Tremoli, E, De Faire, U, Veglia, F, Ford, I, Jukema, JW, Westendorp, RGJ, De Borst, GJ, De Jong, PA, Algra, A, Spiering, W, Der Zee, AHMV, Klungel, OH, De Boer, A, Doevendans, PA, Eaton, CB, Robinson, JG, Duggan, D, Kjekshus, J, Downs, JR, Gotto, AM, Keech, AC, Marchioli, R, Tognoni, G, Sever, PS, Poulter, NR, Waters, DD, Pedersen, TR, Amarenco, P, Nakamura, H, McMurray, JJV, Lewsey, JD, Chasman, DI, Ridker, PM, Maggioni, AP, Tavazzi, L, Ray, KK, Seshasai, SRK, Manson, JE, Price, JF, Whincup, PH, Morris, RW, Lawlor, DA
Publikováno v:
Swerdlow, DI; Preiss, D; Kuchenbaecker, KB; Holmes, MV; Engmann, JEL; Shah, T; et al.(2015). HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: Evidence from genetic analysis and randomised trials. The Lancet, 385(9965), 351-361. doi: 10.1016/S0140-6736(14)61183-1. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3c9569hs
© 2015 Swerdlow et al. Open Access article distributed under the terms of CC BY. Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::93d969557b1276f6c8f9ebd9b77f240d
http://www.escholarship.org/uc/item/3c9569hs
http://www.escholarship.org/uc/item/3c9569hs
Autor:
Holmes, MV, Dale, CE, Zuccolo, L, Silverwood, RJ, Guo, Y, Ye, Z, Prieto-Merino, D, Dehghan, Abbas, Trompet, S, Wong, A, Cavadino, A, Drogan, D, Padmanabhan, S, Li, Shan, Yesupriya, A, Leusink, M, Sundstrom, J, Hubacek, JA, Pikhart, H, Swerdlow, DI, Panayiotou, AG, Borinskaya, SA, Finan, C, Shah, S, Kuchenbaecker, KB, Shah, T, Engmann, J, Folkersen, L, Eriksson, P, Ricceri, F, Melander, O, Sacerdote, C, Gamble, DM, Rayaprolu, S, Ross, OA, McLachlan, S, Vikhireva, O, Sluijs, Iris, Scott, RA, Adamkova, V, Flicker, L, van Bockxmeer, FM, Power, C, Marques-Vidal, P, Meade, T, Marmot, MG, Ferro, JM, Paulos-Pinheiro, S, Humphries, SE, Talmud, PJ, Leach, IM, Verweij, N (Niek), Linneberg, A, Skaaby, T, Doevendans, PA, Cramer, MJ, van der Harst, P, Klungel, OH, Dowling, NF, Dominiczak, AF, Kumari, M, Nicolaides, AN, Weikert, C, Boeing, H, Ebrahim, S, Gaunt, TR, Price, JF, Lannfelt, L, Peasey, A, Kubinova, R, Pajak, A, Malyutina, S, Voevoda, MI, Tamosiunas, A, Zee, AH, Norman, PE, Hankey, GJ, Bergmann, MM, Hofman, Bert, Franco Duran, OH, Cooper, J, Palmen, J, Spiering, W, Jong, PA, Kuh, D, Hardy, R, Uitterlinden, André, Ikram, Arfan, Ford, I, Hyppoenen, E, Almeida, OP, Wareham, NJ, Khaw, KT, Hamsten, A, Husemoen, LLN, Tjonneland, A, Tolstrup, JS, Rimm, E, Beulens, JWJ, Verschuren, WMM, Onland-Moret, NC, Hofker, MH, Wannamethee, SG, Whincup, PH, Morris, R, Vicente, AM, Watkins, H, Farrall, M, Jukema, JW, Meschia, J, Cupples, LA, Sharp, SJ, Fornage, M, Kooperberg, C, Lacroix, AZ, Dai, JY, Lanktree, MB, Siscovick, DS, Jorgenson, E, Spring, B, Coresh, J, Li, YR, Buxbaum, SG, Schreiner, PJ, Ellison, RC, Tsai, MY, Patel, SR, Redline, S, Johnson, AD, Hoogeveen, RC, Rotter, JI, Boerwinkle, E, de Bakker, PIW, Kivimaki, M, Asselbergs, FW, Sattar, N, Lawlor, DA, Whittaker, J, Smith, GD, Mukamal, K, Psaty, BM, Wilson, JG, Lange, LA, Hamidovic, A, Hingorani, AD, Nordestgaard, BG, Bobak, M, Leon, DA, Langenberg, C, Palmer, TM, Reiner, AP, Keating, BJ, Dudbridge, F, Casas, JP
Publikováno v:
BMJ-British medical journal, 349. BMJ Publishing Group
Objective: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. Design: Mendelian randomisation meta-analysis of 56 epidemiological studies. Pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9bce34c69de0a3c4e83beb0ae8fc1f79
https://hdl.handle.net/20.500.14279/3672
https://hdl.handle.net/20.500.14279/3672
Autor:
de Boer LM; Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.; Department of Pediatrics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Wiegman A; Department of Pediatrics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Swerdlow DI; Silence Therapeutics plc, London, UK., Kastelein JJP; Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands., Hutten BA; Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Publikováno v:
Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2022 Oct; Vol. 23 (14), pp. 1601-1615. Date of Electronic Publication: 2022 Sep 12.
Autor:
Nissen SE; Cleveland Clinic Center for Clinical Research, Cleveland, Ohio., Wolski K; Cleveland Clinic Center for Clinical Research, Cleveland, Ohio., Balog C; Cleveland Clinic Center for Clinical Research, Cleveland, Ohio., Swerdlow DI; Silence Therapeutics PLC, London, England., Scrimgeour AC; Silence Therapeutics PLC, London, England., Rambaran C; Silence Therapeutics PLC, London, England., Wilson RJ; Spica Consultants Ltd, Marlborough, England., Boyce M; UK Hammersmith Medicines Research, London, England., Ray KK; Imperial College London, London, England., Cho L; Cleveland Clinic Center for Clinical Research, Cleveland, Ohio., Watts GF; Royal Perth Hospital and School of Medicine, Departments of Cardiology and Internal Medicine, University of Western Australia, Perth, Australia., Koren M; Jacksonville Center for Clinical Research, Jacksonville, Florida., Turner T; Medpace, Cincinnati, Ohio., Stroes ES; Faculty of Medicine, University of Amsterdam, Amsterdam, the Netherlands., Melgaard C; Cleveland Clinic Center for Clinical Research, Cleveland, Ohio., Campion GV; Silence Therapeutics PLC, London, England.
Publikováno v:
JAMA [JAMA] 2022 May 03; Vol. 327 (17), pp. 1679-1687.
Autor:
Rider DA; Silence Therapeutics GmbH, Robert-Rössle-Straße 10, 13125, Berlin, Germany. Electronic address: d.rider@silence-therapeutics.com., Eisermann M; Silence Therapeutics GmbH, Robert-Rössle-Straße 10, 13125, Berlin, Germany., Löffler K; Silence Therapeutics GmbH, Robert-Rössle-Straße 10, 13125, Berlin, Germany., Aleku M; Silence Therapeutics GmbH, Robert-Rössle-Straße 10, 13125, Berlin, Germany., Swerdlow DI; Silence Therapeutics PLC, 72 Hammersmith Road, London, W14 8TH, London, UK., Dames S; Silence Therapeutics GmbH, Robert-Rössle-Straße 10, 13125, Berlin, Germany., Hauptmann J; Silence Therapeutics GmbH, Robert-Rössle-Straße 10, 13125, Berlin, Germany., Morrison E; Silence Therapeutics GmbH, Robert-Rössle-Straße 10, 13125, Berlin, Germany., Lindholm MW; Silence Therapeutics GmbH, Robert-Rössle-Straße 10, 13125, Berlin, Germany., Schubert S; Silence Therapeutics GmbH, Robert-Rössle-Straße 10, 13125, Berlin, Germany., Campion G; Silence Therapeutics PLC, 72 Hammersmith Road, London, W14 8TH, London, UK.
Publikováno v:
Atherosclerosis [Atherosclerosis] 2022 May; Vol. 349, pp. 240-247. Date of Electronic Publication: 2022 Apr 01.
Autor:
Swerdlow DI; Silence Therapeutics plc, 72 Hammersmith Road, London W14 8TH, UK., Rider DA; Silence Therapeutics plc, 72 Hammersmith Road, London W14 8TH, UK., Yavari A; Experimental Therapeutics, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK., Wikström Lindholm M; Silence Therapeutics plc, 72 Hammersmith Road, London W14 8TH, UK., Campion GV; Silence Therapeutics plc, 72 Hammersmith Road, London W14 8TH, UK., Nissen SE; Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Publikováno v:
Cardiovascular research [Cardiovasc Res] 2022 Mar 25; Vol. 118 (5), pp. 1218-1231.