Nonclinical pharmacokinetics and biodistribution of VSV-GP using methods to decouple input drug disposition and viral replication.

Autor: Dambra R; Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA.; Drexel University School of Biomedical Engineering, Science and Health Systems, Philadelphia, PA 19104, USA., Matter A; Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Graca K; Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Akhand SS; Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Mehta S; Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Bell-Cohn A; Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Swenson JM; Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Abid S; Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Xin D; Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Lewis C; Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Coyle L; Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Wang M; Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Bunosso K; Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Maugiri M; Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Ruiz R; Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Cirillo CM; Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Fogal B; Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Grimaldi C; Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Vigil A; Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Wood C; Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA., Ashour J; Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2022 Dec 28; Vol. 28, pp. 190-207. Date of Electronic Publication: 2022 Dec 28 (Print Publication: 2023).

Critical reagent generation, characterization, handling and storage workflows: impact on ligand binding assays.

Autor: Oquendo E; Drug Metabolism & Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877-0368, USA., Savoie J; Drug Metabolism & Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877-0368, USA., Swenson JM; Drug Metabolism & Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877-0368, USA., Grimaldi C; Drug Metabolism & Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877-0368, USA.

Publikováno v: Bioanalysis [Bioanalysis] 2021 May; Vol. 13 (10), pp. 847-860. Date of Electronic Publication: 2021 Apr 23.

What is the impact of an Abnormal pathogenic variant in COQ8A/CYP17A1 in pediatric patient - A case report.

Autor: Alrowaished, Bader Basem¹ Bader.Ruw@gmail.com, Ali, Elsayed¹, Alhejji, Mohammed Saeed¹, Albohassen, Mohammed Sami¹, Aldandan, Ali Mohammed¹

Publikováno v: European Journal of Medical Case Reports. 2024, Vol. 8 Issue 8, p1-5. 15p.

Swelling as a stabilizing mechanism in irradiated thin films.

Autor: Swenson JM; Department of Mathematics, Southern Methodist University, Dallas, TX 75275, United States of America., Norris SA

Publikováno v: Journal of physics. Condensed matter : an Institute of Physics journal [J Phys Condens Matter] 2018 Aug 01; Vol. 30 (30), pp. 304003. Date of Electronic Publication: 2018 Jun 08.

Linking soil biology and chemistry in biological soil crust using isolate exometabolomics.

Autor: Swenson TL; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA, 94720, USA., Karaoz U; Climate and Ecosystems Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA, 94720, USA., Swenson JM; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA, 94720, USA., Bowen BP; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA, 94720, USA.; DOE Joint Genome Institute, 2800 Mitchell Dr., Walnut Creek, CA, 94598, USA., Northen TR; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA, 94720, USA. TRNorthen@lbl.gov.; DOE Joint Genome Institute, 2800 Mitchell Dr., Walnut Creek, CA, 94598, USA. TRNorthen@lbl.gov.

Publikováno v: Nature communications [Nat Commun] 2018 Jan 02; Vol. 9 (1), pp. 19. Date of Electronic Publication: 2018 Jan 02.