Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Swenja Schuhmacher"'
Autor:
Ari Waisman, Helmut Jonuleit, Stephan Grabbe, Eberhard Schulz, Matthias Oelze, Andreas Daiber, Susanne Karbach, Maike Knorr, Nir Yogev, Michael Hausding, Sabine Kossmann, Swenja Schuhmacher, Philip Wenzel, Christian Becker, Melanie Schwenk, Jan Stratmann, Thomas Münzel
Publikováno v:
Circulation. 124:1370-1381
Background— Angiotensin II (ATII), a potent vasoconstrictor, causes hypertension, promotes infiltration of myelomonocytic cells into the vessel wall, and stimulates both vascular and inflammatory cell NADPH oxidases. The predominant source of react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a12c6fad95fc05b56e7e42aac6b89e
https://doi.org/10.1161/circulationaha.111.034470
https://doi.org/10.1161/circulationaha.111.034470
Autor:
Sebastian Steven, Andrea Pautz, Swenja Schuhmacher, Franziska Bollmann, Tommaso Gori, Eberhard Schulz, Philip Wenzel, Michael Hausding, Andreas Daiber, Kurt Reifenberg, Hartmut Kleinert, Maike Knorr, Tjebo F. C. Heeren, Christian Otto, Matthias Oelze, Thomas Münzel
Publikováno v:
Diabetes
OBJECTIVE Diabetes is associated with vascular oxidative stress, activation of NADPH oxidase, and uncoupling of nitric oxide (NO) synthase (endothelial NO synthase [eNOS]). Pentaerithrityl tetranitrate (PETN) is an organic nitrate with potent antioxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f3bdf76acfbd8fc27eae7590ab4d01
http://europepmc.org/articles/PMC3178293
http://europepmc.org/articles/PMC3178293
Autor:
Philip Wenzel, Swenja Schuhmacher, Andrei L. Kleschyov, Benoit Viollet, Eberhard Schulz, Karl J. Lackner, John F. Keaney, Matthias Oelze, Thomas Münzel, Maike Knorr, Marc Foretz, Marcus Hortmann, Gerhard Wegener, Andreas Daiber, Thomas Jansen
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 31:560-566
Objective— Besides its well-described metabolic effects, vascular AMP-activated protein kinase (AMPK) can activate endothelial NO synthase, promotes angiogenesis, and limits endothelial cell apoptosis. The current study was designed to study the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46ccca7e477cba548435ba94676a6cd
https://doi.org/10.1161/atvbaha.110.219543
https://doi.org/10.1161/atvbaha.110.219543
Autor:
Tjebo F. C. Heeren, Maike Knorr, Matthias Oelze, Eberhard Schulz, Andreas Daiber, Swenja Schuhmacher, Kurt Reifenberg, Philip Wenzel, Thomas Münzel, Christian Otto
Publikováno v:
Journal of Vascular Research. 48:275-284
Objective: In previous studies we and others have shown that streptozotocin (STZ)-induced diabetes in rats is associated with vascular oxidative stress and dysfunction. In the present study, we sought to determine whether vascular dysfunction and oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdd7bcc5a98867ab00ce9d27817ac1c
https://doi.org/10.1159/000320627
https://doi.org/10.1159/000320627
Autor:
Andreas Daiber, Philip Wenzel, Thomas Jansen, Richard Schell, Susanne Karbach, Thomas Münzel, Benjamin Opitz, Sebastian Steven, Matthias Oelze, Swenja Schuhmacher, Maike Knorr, Marcus Hortmann
Publikováno v:
Journal of Molecular and Cellular Cardiology. 49:186-195
Heme oxygenase-1 (HO-1) is highly protective in various pathophysiological states such as cardiovascular and neurodegenerative diseases. HO-1-derived bilirubin is an efficient scavenger of reactive oxygen and nitrogen species (RONS). It remains to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f823ccddae335a624e3dcbba202ae554
https://doi.org/10.1016/j.yjmcc.2010.04.011
https://doi.org/10.1016/j.yjmcc.2010.04.011
Publikováno v:
Experimental Diabetes Research
Experimental Diabetes Research, Vol 2010 (2010)
Experimental Diabetes Research, Vol 2010 (2010)
Organic nitrates represent a class of drugs which are clinically used for treatment of ischemic symptoms of angina as well as for congestive heart failure based on the idea to overcome the impaired NO bioavailability by “NO” replacement therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838d0b50f11230426a14d66a1b08ba23
https://doi.org/10.1155/2010/213176
https://doi.org/10.1155/2010/213176
Autor:
Philip Wenzel, Jochen Lehmann, Andreas Daiber, Carolin Roegler, Matthias Oelze, Andreas König, Toshihiro Kawamoto, Eberhard Schulz, Thomas Münzel, L Sydow, Kathrin Lange, Swenja Schuhmacher
Publikováno v:
British Journal of Pharmacology. 158:510-520
Background and purpose: The chronic use of organic nitrates is limited by serious side effects including oxidative stress, nitrate tolerance and/or endothelial dysfunction. The side effects and potency of nitroglycerine depend on mitochondrial aldehy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd74a419a33e44af519b7a89374b8e51
https://doi.org/10.1111/j.1476-5381.2009.00303.x
https://doi.org/10.1111/j.1476-5381.2009.00303.x
Autor:
Thomas Jansen, Thomas Münzel, Swenja Schuhmacher, Michael Torzewski, Karl J. Lackner, Andreas Daiber, Matthias Oelze, Philip Wenzel, Jennifer M. Dias Wickramanayake
Publikováno v:
Pharmacological Reports. 61:33-48
Organic nitrates are a group of very effective anti-ischemic drugs. They are used for the treatment of patients with stable angina, acute myocardial infarction and chronic congestive heart failure. A major therapeutic limitation inherent to organic n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a778929ca675e6e9c38a30926fad10a9
https://doi.org/10.1016/s1734-1140(09)70005-2
https://doi.org/10.1016/s1734-1140(09)70005-2
Autor:
Andreas Daiber, Philip Wenzel, Thomas Münzel, Shane R. Thomas, Jörn F. Dopheide, John F. Keaney, Kai Chen, Eberhard Schulz, Swenja Schuhmacher
Publikováno v:
Circulation. 118:1347-1357
Background— Oxidative injury and dysfunction of the vascular endothelium are early and causal features of many vascular diseases. Single antioxidant strategies to prevent vascular injury have met with mixed results. Methods and Results— Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a206d6ee43c476815cd35bbb98be12
https://doi.org/10.1161/circulationaha.108.784298
https://doi.org/10.1161/circulationaha.108.784298
Autor:
Stephan Baldus, Ralf P. Brandes, Johanna Müller, Thomas Münzel, Swenja Schuhmacher, Eberhard Schulz, Andreas Daiber, Tommaso Gori, Matthias Oelze, Hanke Mollnau, Jennifer M. Dias Wickramanayake, Philip Wenzel, Marcus Hortmann
Publikováno v:
Antioxidants & Redox Signaling. 10:1435-1448
Chronic nitroglycerin treatment results in development of nitrate tolerance associated with endothelial dysfunction (ED). We sought to clarify how mitochondria- and NADPH oxidase (Nox)-derived reactive oxygen species (ROS) contribute to nitrate toler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e56026de3cb3ba4581436a39a860bee
https://doi.org/10.1089/ars.2007.1969
https://doi.org/10.1089/ars.2007.1969