Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Swen Engelmann"'
Autor:
Harald Arnold, Kasper Hoebe, Anna Katharina Koller, Annegret Reinhold, Swen Engelmann, Stephanie Schmidt, Sidonia Mihai, Christian Bogdan, Maike Willers, Christoph Daniel, Hans Parsch, Julia L.C. Baier, Robert Opoka, Stefanie Kliche, Claudia Giessler, Claudia Danzer, Stefan Wirtz, Jochen Mattner
Publikováno v:
European Journal of Immunology. 46:2121-2136
TCR ligation is critical for the selection, activation, and integrin expression of T lymphocytes. Here, we explored the role of the TCR adaptor protein slp-76 on iNKT-cell biology. Compared to B6 controls, slp-76(ace/ace) mice carrying a missense mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8215b585c0a5b15f7eeeb4c765c57780
https://doi.org/10.1002/eji.201646331
https://doi.org/10.1002/eji.201646331
Autor:
Joachim R. Göthert, Pegah Seddigh, Zeinab Abdullah, Franziska Neumann, Ari Waisman, Mike Hasenberg, Anika Klingberg, Sabrina Klebow, Michaela Seeling, Swen Engelmann, Sven Brandau, Annegret Reinhold, Anja Hasenberg, Linda Männ, Andreas Kraus, Manuel Stecher, Lars Borkenstein, Burkhart Schraven, Daniel R. Engel, Matthias Gunzer, Falk Nimmerjahn
Publikováno v:
Nature Methods. 12:445-452
Neutrophil granulocyte biology is a central issue of immunological research, but the lack of animal models that allow for neutrophil-selective genetic manipulation has delayed progress. By modulating the neutrophil-specific locus Ly6G with a knock-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ffb343dc029a602d3d765d797799a0
https://doi.org/10.1038/nmeth.3322
https://doi.org/10.1038/nmeth.3322
Autor:
Mauro Togni, Swen Engelmann, Burkhart Schraven, Anja Thielitz, Annegret Reinhold, Peter Reichardt, Dirk Reinhold, Stefanie Kliche
Publikováno v:
The Journal of Immunology
The Journal of Immunology; Vol 191
The Journal of Immunology; Vol 191
The adhesion- and degranulation-promoting adaptor protein (ADAP), expressed in T cells, myeloid cells, and platelets, is known to regulate receptor-mediated inside-out signaling leading to integrin activation and adhesion. In this study, we demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a12d7e3d498310ccf37543a0cbf444c
Publikováno v:
The Journal of Immunology. 183:6124-6134
Protein kinase B (PKB)/Akt signals control T cell proliferation and differentiation but their effect on the generation and function of regulatory T cells (Treg) and Th17 cells is not well understood. In this study, we show that elevated PKB signals a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e406a19d66136402c4ac9817d109a0a
https://doi.org/10.4049/jimmunol.0900246
https://doi.org/10.4049/jimmunol.0900246
Autor:
Swen Engelmann, Burkhart Schraven, Dirk Reinhold, Stefanie Kliche, Mauro Togni, Annegret Reinhold
Publikováno v:
Critical reviews in immunology. 35(1)
Adaptor proteins mediate protein-protein interactions in signal transduction cascades. These signaling molecules are organized in multimolecular complexes that translate information from cell surface receptors into cellular responses. The cytosolic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1674f8c2e5d61ad8902c249b160544f4
https://pubmed.ncbi.nlm.nih.gov/25746044
https://pubmed.ncbi.nlm.nih.gov/25746044
Publikováno v:
Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 10, Iss 1, p 14 (2012)
Cell Communication and Signaling, Vol 10, Iss 1, p 14 (2012)
Background The cytosolic adaptor protein ADAP (adhesion and degranulation promoting adapter protein) is expressed by T cells, natural killer cells, myeloid cells and platelets. ADAP is involved in T-cell-receptor-mediated inside-out signaling, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318335a20ca24d9c3f0a4ad74d4fdad5
https://doi.org/10.1186/1478-811x-10-14
https://doi.org/10.1186/1478-811x-10-14
Autor:
Thomas Drewes, Swen Engelmann, Sergei Chuvpilo, Amiya K. Patra, Edgar Serfling, Ursula Bommhardt, Thomas Hünig, Hiroyuki Kishi
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 177(7)
Protein kinase B (PKB), an Ag receptor activated serine-threonine kinase, controls various cellular processes including proliferation and survival. However, PKB function in thymocyte development is still unclear. We report PKB as an important negativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51bf3889cd4a84d19dc1f767af52138
https://pubmed.ncbi.nlm.nih.gov/16982894
https://pubmed.ncbi.nlm.nih.gov/16982894