Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sweilem B. Al Rihani"'
Autor:
Matt K. Smith, Ravil Bikmetov, Sweilem B. Al Rihani, Malavika Deodhar, Matthew Hafermann, Pamela Dow, Jacques Turgeon, Veronique Michaud
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1799-1809 (2021)
Abstract Drug safety is generally established from clinical trials, by pharmacovigilance programs and during observational phase IV safety studies according to drug intended or approved indications. The objective of this study was to estimate the ris
Externí odkaz:
https://doaj.org/article/8b20c6c90a4d4eacb57f42d694c98311
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9261 (2023)
The blood–brain barrier (BBB) is a complex network of tightly regulated cells and transport proteins that separate the circulating blood from the brain tissue [...]
Externí odkaz:
https://doaj.org/article/d760f3156f974475903649dd6137e71c
Autor:
Veronique Michaud, Pamela Dow, Sweilem B. Al Rihani, Malavika Deodhar, Meghan Arwood, Brian Cicali, Jacques Turgeon
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 20-28 (2021)
The risk‐benefit ratio associated with the use of repurposed drugs to treat severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2)‐related infectious coronavirus disease 2019 (COVID‐19) is complicated because benefits are awaited, n
Externí odkaz:
https://doaj.org/article/7b0134e271904183b0b675bed0a380a2
Autor:
Sweilem B. Al Rihani, Lucy I. Darakjian, Malavika Deodhar, Pamela Dow, Jacques Turgeon, Veronique Michaud
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3742 (2021)
The blood–brain barrier (BBB) is a highly selective and restrictive semipermeable network of cells and blood vessel constituents. All components of the neurovascular unit give to the BBB its crucial and protective function, i.e., to regulate homeos
Externí odkaz:
https://doaj.org/article/9000b66328e24821ae29e38d264ebacb
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 148 (2021)
Fluoxetine is still one of the most widely used antidepressants in the world. The drug is extensively metabolized by several cytochrome P450 (CYP450) enzymes and subjected to a myriad of CYP450-mediated drug interactions. In a multidrug regimen, pree
Externí odkaz:
https://doaj.org/article/4fa3b7aa875e43158200d3a492b92189
Autor:
Sweilem B. Al Rihani, Matt K. Smith, Ravil Bikmetov, Malavika Deodhar, Pamela Dow, Jacques Turgeon, Veronique Michaud
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 8, p 2591 (2020)
Determination of the risk–benefit ratio associated with the use of novel coronavirus disease 2019 (COVID-19) repurposed drugs in older adults with polypharmacy is mandatory. Our objective was to develop and validate a strategy to assess risk for ad
Externí odkaz:
https://doaj.org/article/3de957d4f4574495875260b90f213f6c
Autor:
Yazan S. Batarseh, Quoc-Viet Duong, Youssef M. Mousa, Sweilem B. Al Rihani, Khaled Elfakhri, Amal Kaddoumi
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 3, p 338 (2016)
Amyloid-β (Aβ) pathology is known to promote chronic inflammatory responses in the brain. It was thought previously that Aβ is only associated with Alzheimer’s disease and Down syndrome. However, studies have shown its involvement in many other
Externí odkaz:
https://doaj.org/article/639ed7ae4a0246169cbed3cb345b3bd1
Autor:
Veronique Michaud, Matt K Smith, Malavika Deodhar, Pamela Dow, Lucy I Darakjian, Ravil Bikmetov, Jacques Turgeon, Sweilem B Al Rihani
Publikováno v:
Drugs & Aging
Background Patients taking medication with high anticholinergic and sedative properties are at increased risk of experiencing poor cognitive and physical outcomes. Therefore, precise quantification of the cumulative burden of their drug regimen is ad
Autor:
Meghan Ha, Anna Furman, Sweilem B. Al Rihani, Veronique Michaud, Jacques Turgeon, David L. Bankes
Publikováno v:
Journal of the American Geriatrics SocietyREFERENCES. 70(11)
Given associations with serious cognitive and physical adverse effects (e.g., dementia, falls), strong anticholinergics, like urinary antimuscarinics (UAMs), should be avoided in older adults. This feasibility study aimed to (1) evaluate the implemen
Publikováno v:
Journal of Alzheimer's Disease. 72:1097-1117
Alzheimer’s disease is characterized by a compromised blood-brain barrier and disrupted intracellular calcium homeostasis in the brain. Therefore, rectifying the blood-brain barrier (BBB) integrity and restoring calcium homeostasis could provide an