EP2/EP4 targeting prevents tumor-derived PGE2-mediated immunosuppression in cDC2s.

Autor: Cuenca-Escalona J; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands., Bödder J; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands., Subtil B; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands., Sánchez-Sánchez M; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands., Vidal-Manrique M; Laboratory of Hematology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands., Sweep MWD; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands.; Department of Medical Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands., Fauerbach JA; R&D Reagents, Chemical Biology Department; Miltenyi Biotec B.V. & Co. KG, Friedrich-Ebert-Straße 68, 51429, Bergisch Gladbach, Germany., Cambi A; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands., Flórez-Grau G; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands., de Vries JM; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands.

Publikováno v: Journal of leukocyte biology [J Leukoc Biol] 2024 Nov 27; Vol. 116 (6), pp. 1554-1567.

Case Report: A severe case of immunosuppressant-refractory immune checkpoint inhibitor-mediated colitis rescued by tofacitinib.

Autor: Sweep MWD; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, Netherlands., Tjan MJH; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, Netherlands., Gorris MAJ; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, Netherlands.; Division of Immunotherapy, Oncode Institute, Nijmegen, Netherlands., Bol KF; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, Netherlands., Westdorp H; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, Netherlands.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Jun 26; Vol. 14, pp. 1212432. Date of Electronic Publication: 2023 Jun 26 (Print Publication: 2023).

Probing Single-Cell Macrophage Polarization and Heterogeneity Using Thermo-Reversible Hydrogels in Droplet-Based Microfluidics.

Autor: Tiemeijer BM; Laboratory of Immunoengineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.; Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands., Sweep MWD; Laboratory of Immunoengineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.; Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands., Sleeboom JJF; Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.; Microsystems, Department of Mechanical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.; Laboratory of Soft Tissue Engineering and Biomechanics, Department Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands., Steps KJ; Laboratory of Immunoengineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.; Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands., van Sprang JF; Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.; Laboratory of Soft Tissue Engineering and Biomechanics, Department Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands., De Almeida P; Department of System Chemistry, Institute for Molecules and Materials, Radboud University, Nijmegen, Netherlands., Hammink R; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.; Oncode Institute, Radboud University Medical Center, Nijmegen, Netherlands., Kouwer PHJ; Department of System Chemistry, Institute for Molecules and Materials, Radboud University, Nijmegen, Netherlands., Smits AIPM; Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.; Laboratory of Soft Tissue Engineering and Biomechanics, Department Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands., Tel J; Laboratory of Immunoengineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.; Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.

Publikováno v: Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2021 Oct 14; Vol. 9, pp. 715408. Date of Electronic Publication: 2021 Oct 14 (Print Publication: 2021).

Class II HLA-DRB4 is a predictive biomarker for survival following immunotherapy in metastatic non-small cell lung cancer.

Autor: Jiang, Cindy Y.^1,2 (AUTHOR), Zhao, Lili³ (AUTHOR), Green, Michael D.⁴ (AUTHOR), Ravishankar, Shashidhar⁵ (AUTHOR), Towlerton, Andrea M. H.⁵ (AUTHOR), Scott, Anthony J.⁶ (AUTHOR), Raghavan, Malini⁷ (AUTHOR), Cusick, Matthew F.⁸ (AUTHOR), Warren, Edus H.⁵ (AUTHOR), Ramnath, Nithya^9,10 (AUTHOR) nithyar@med.umich.edu

Publikováno v: Scientific Reports. 1/3/2024, Vol. 13 Issue 1, p1-11. 11p.

Immune checkpoint inhibitor colitis, a rising issue in targeted cancer therapy era: A literature review.

Autor: Adiwinata, Randy, Tandarto, Kevin, Tanadi, Caroline, Waleleng, Bradley Jimmy, Haroen, Harlinda, Rotty, Linda, Gosal, Fandy, Rotty, Luciana, Hendratta, Cecilia, Lasut, Pearla, Winarta, Jeanne, Waleleng, Andrew, Simadibrata, Paulus, Simadibrata, Marcellus

Publikováno v: Romanian Journal of Internal Medicine; Sep2024, Vol. 62 Issue 3, p219-230, 12p