Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes.

Autor: Atreya MR; Division of Critical Care Medicine, MLC2005, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA. Mihir.Atreya@cchmc.org.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45627, USA. Mihir.Atreya@cchmc.org., Huang M; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA., Moore AR; Stanford Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA., Zheng H; Stanford Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.; Center for Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA., Hasin-Brumshtein Y; Inflammatix, Sunnyvale, CA, 94085, USA., Fitzgerald JC; Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Weiss SL; Nemours Children's Health, Wilmington, DE, 19803, USA., Cvijanovich NZ; UCSF Benioff Children's Hospital Oakland, Oakland, CA, 94609, USA., Bigham MT; Akron Children's Hospital, Akron, OH, 44308, USA., Jain PN; Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA., Schwarz AJ; Children's Hospital of Orange County, Orange, CA, 92868, USA., Lutfi R; Riley Hospital for Children, Indianapolis, IN, 46202, USA., Nowak J; Children's Hospital and Clinics of Minnesota, Minneapolis, MN, 55404, USA., Thomas NJ; Penn State Hershey Children's Hospital, Hershey, PA, 17033, USA., Quasney M; C.S Mott Children's Hospital, University of Michigan, Ann Arbor, MI, 48109, USA., Dahmer MK; C.S Mott Children's Hospital, University of Michigan, Ann Arbor, MI, 48109, USA., Baines T; University of Florida Health Children's Hospital, Gainesville, FL, 32610, USA., Haileselassie B; Lucile Packard Children's Hospital Stanford, Palo Alto, CA, 94304, USA., Lautz AJ; Division of Critical Care Medicine, MLC2005, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45627, USA., Stanski NL; Division of Critical Care Medicine, MLC2005, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45627, USA., Standage SW; Division of Critical Care Medicine, MLC2005, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45627, USA., Kaplan JM; Division of Critical Care Medicine, MLC2005, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45627, USA., Zingarelli B; Division of Critical Care Medicine, MLC2005, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45627, USA., Sahay R; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA., Zhang B; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA., Sweeney TE; Inflammatix, Sunnyvale, CA, 94085, USA., Khatri P; Stanford Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.; Center for Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA., Sanchez-Pinto LN; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Department of Health and Biomedical Informatics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Kamaleswaran R; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30322, USA.

Publikováno v: Critical care (London, England) [Crit Care] 2024 Jul 17; Vol. 28 (1), pp. 246. Date of Electronic Publication: 2024 Jul 17.

Multisite validation of a host response signature for predicting likelihood of bacterial and viral infections in patients with suspected influenza.

Autor: Shojaei M; Department of Medicine, Sydney Medical School Nepean, Nepean Hospital, University of Sydney, Penrith, New South Wales, Australia.; Department of Intensive Care Medicine, Nepean Hospital, Penrith, New South Wales, Australia.; Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Westmead, New South Wales, Australia., Chen UI; Inflammatix, Inc., Sunnyvale, California, USA., Midic U; Inflammatix, Inc., Sunnyvale, California, USA., Thair S; Inflammatix, Inc., Sunnyvale, California, USA., Teoh S; Department of Intensive Care Medicine, Nepean Hospital, Penrith, New South Wales, Australia., McLean A; Department of Intensive Care Medicine, Nepean Hospital, Penrith, New South Wales, Australia., Sweeney TE; Inflammatix, Inc., Sunnyvale, California, USA., Thompson M; Inflammatix, Inc., Sunnyvale, California, USA., Liesenfeld O; Inflammatix, Inc., Sunnyvale, California, USA., Khatri P; Inflammatix, Inc., Sunnyvale, California, USA., Tang B; Department of Intensive Care Medicine, Nepean Hospital, Penrith, New South Wales, Australia.; Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.

Publikováno v: European journal of clinical investigation [Eur J Clin Invest] 2023 May; Vol. 53 (5), pp. e13957. Date of Electronic Publication: 2023 Feb 08.

Transitions of blood immune endotypes and improved outcome by anakinra in COVID-19 pneumonia: an analysis of the SAVE-MORE randomized controlled trial.

Autor: Kyriazopoulou E; 4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Hasin-Brumshtein Y; Inflammatix, Inc., Sunnyvale, CA, USA., Midic U; Inflammatix, Inc., Sunnyvale, CA, USA., Poulakou G; 3rd Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Milionis H; 1st Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece., Metallidis S; 1st Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Astriti M; 1st Department of Internal Medicine, G. Gennimatas General Hospital of Athens, Athens, Greece., Fragkou A; Department of Internal Medicine, Elpis General Hospital, Athens, Greece., Rapti A; 2nd Department of Pulmonary Medicine, Sotiria General Hospital of Chest Diseases, Athens, Greece., Taddei E; Dipartimento Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Gemelli IRCCS, Rome, Italy., Kalomenidis I; 1st Department of Critical Care and Pulmonary Medicine, Medical School, National and Kapodistrian University of Athens, Evangelismos General Hospital, Athens, Greece., Chrysos G; 2nd Department of Internal Medicine, Tzaneio General Hospital of Piraeus, Athens, Greece., Angheben A; Department of Infectious - Tropical Diseases and Microbiology, IRCSS Sacro Cuore Hospital, Negrar, Verona, Italy., Kainis I; 10th Department of Pulmonary Medicine, Sotiria General Hospital of Chest Diseases of Athens, Athens, Greece., Alexiou Z; 2nd Department of Internal Medicine, Thriasio General Hospital of Eleusis, Athens, Greece., Castelli F; Spedali Civili, Brescia ASST Spedali Civili Hospital, University of Brescia, Brescia, Italy., Serino FS; Department of Internal Medicine, Hospital of Jesolo, Jesolo, Italy., Bakakos P; 1st Department of Chest Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Nicastri E; Department of Internal Medicine, Spallanzani Institute of Rome, Rome, Italy., Tzavara V; 1st Department of Internal Medicine, Korgialeneion-Benakeion General Hospital, Athens, Greece., Ioannou S; Department of Therapeutics, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Dagna L; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy., Dimakou K; 5th Department of Pulmonary Medicine, Sotiria General Hospital of Chest Diseases, Athens, Athens, Greece., Tzatzagou G; 1st Department of Internal Medicine, Papageorgiou General Hospital of Thessaloniki, Thessaloniki, Greece., Chini M; 3rd Department of Internal Medicine and Infectious Diseases Unit, Korgialeneion-Benakeion General Hospital, Athens, Greece., Bassetti M; Infectious Diseases Clinic, Ospedale Policlinico San Martino IRCCS and Department of Health Sciences, University of Genova, Genova, Italy., Kotsis V; 3rd Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Tsoukalas DG; 4th Department of Pulmonary Medicine, Sotiria General Hospital of Chest Diseases, Athens, Greece., Selmi C; Department of Biomedical Sciences, Humanitas University and IRCCS Humanitas Research Hospital, Milan, Italy., Konstantinou A; 1st Department of Internal Medicine, Asklepieio General Hospital of Voula, Voula, Greece., Samarkos M; 1st Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Doumas M; 2nd Department of Propedeutic Medicine, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Masgala A; 2nd Department of Internal Medicine, Konstantopouleio General Hospital, Athens, Greece., Pagkratis K; Department of Pulmonary Medicine, General Hospital of Kerkyra, Corfu, Greece., Argyraki A; Department of Internal Medicine, Sotiria General Hospital of Chest Diseases, Athens, Greece., Akinosoglou K; Department of Internal Medicine, University of Patras, Patras, Greece., Symbardi S; 1st Department of Internal Medicine, Thriasio General Hospital of Eleusis, Athens, Greece., Netea MG; Department of Internal Medicine and Center for Infectious Diseases, Radboud University, Nijmegen, The Netherlands.; Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany., Panagopoulos P; 2nd Department of Internal Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece., Dalekos GN; Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, European Reference Network on Hepatological Diseases (ERN RARE-LIVER), General University Hospital of Larissa, Larissa, Greece., Liesenfeld O; Inflammatix, Inc., Sunnyvale, CA, USA., Sweeney TE; Inflammatix, Inc., Sunnyvale, CA, USA., Khatri P; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA.; Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA, USA., Giamarellos-Bourboulis EJ; 4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece. egiamarel@med.uoa.gr.; 4th Department of Internal Medicine, ATTIKON University Hospital, 1 Rimini Street, 124 62, Athens, Greece. egiamarel@med.uoa.gr.

Publikováno v: Critical care (London, England) [Crit Care] 2024 Mar 12; Vol. 28 (1), pp. 73. Date of Electronic Publication: 2024 Mar 12.

A 29-MRNA HOST RESPONSE WHOLE-BLOOD SIGNATURE IMPROVES PREDICTION OF 28-DAY MORTALITY AND 7-DAY INTENSIVE CARE UNIT CARE IN ADULTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH SUSPECTED ACUTE INFECTION AND/OR SEPSIS.

Autor: Kostaki A; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Greece., Wacker JW; Inflammatix Inc., Burlingame, California., Safarika A; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Greece., Solomonidi N; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Greece., Katsaros K; Department of Surgery, Nafplion General Hospital, Greece., Giannikopoulos G; Department of Internal Medicine, Syros General Hospital, Greece., Koutelidakis IM; 2nd Department of Surgery, Aristotle University of Thessaloniki, Greece., Hogan CA; Inflammatix Inc., Burlingame, California., Uhle F; Inflammatix Inc., Burlingame, California., Liesenfeld O; Inflammatix Inc., Burlingame, California., Sweeney TE; Inflammatix Inc., Burlingame, California., Giamarellos-Bourboulis EJ; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Greece.

Publikováno v: Shock (Augusta, Ga.) [Shock] 2022 Sep 01; Vol. 58 (3), pp. 224-230. Date of Electronic Publication: 2022 Aug 26.

A Novel 29-Messenger RNA Host-Response Assay From Whole Blood Accurately Identifies Bacterial and Viral Infections in Patients Presenting to the Emergency Department With Suspected Infections: A Prospective Observational Study.

Autor: Bauer W; Department of Emergency Medicine, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany., Kappert K; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Berlin, Germany., Galtung N; Department of Emergency Medicine, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany., Lehmann D; Department of Emergency Medicine, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany., Wacker J; Inflammatix, Burlingame, CA., Cheng HK; Inflammatix, Burlingame, CA., Liesenfeld O; Inflammatix, Burlingame, CA., Buturovic L; Inflammatix, Burlingame, CA., Luethy R; Inflammatix, Burlingame, CA., Sweeney TE; Inflammatix, Burlingame, CA., Tauber R; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Berlin, Germany., Somasundaram R; Department of Emergency Medicine, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany.

Publikováno v: Critical care medicine [Crit Care Med] 2021 Oct 01; Vol. 49 (10), pp. 1664-1673.