Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Swee Hoe Ong"'
Autor:
Kasumi Murai, Stefan Dentro, Swee Hoe Ong, Roshan Sood, David Fernandez-Antoran, Albert Herms, Vasiliki Kostiou, Irina Abnizova, Benjamin A. Hall, Moritz Gerstung, Philip H. Jones
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Ageing normal oesophagus epithelium contains p53 mutant clones. Here the authors use transgenic mice to show how these clones form and contribute to cancer development.
Externí odkaz:
https://doaj.org/article/1dd89c9fd24a483699e9a724ff044c1c
Autor:
Irene Bassano, Swee Hoe Ong, Maximo Sanz-Hernandez, Michal Vinkler, Adebabay Kebede, Olivier Hanotte, Ebele Onuigbo, Mark Fife, Paul Kellam
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background The interferon-induced transmembrane (IFITM) protein family comprises a class of restriction factors widely characterised in humans for their potent antiviral activity. Their biological activity is well documented in several anima
Externí odkaz:
https://doaj.org/article/c75ecc1afd3147acae3b42503d220244
Autor:
Muxin Gu, Maximillian Zwiebel, Swee Hoe Ong, Nick Boughton, Josep Nomdedeu, Faisal Basheer, Yasuhito Nannya, Pedro M. Quiros, Seishi Ogawa, Mario Cazzola, Roland Rad, Adam P. Butler, MS Vijayabaskar, George S. Vassiliou
Publikováno v:
Haematologica, Vol 105, Iss 6 (2020)
Externí odkaz:
https://doaj.org/article/a2c3b7eb743546c79a810d80e07d29a2
Publikováno v:
Cell Reports, Vol 24, Iss 2, Pp 489-502 (2018)
Summary: The genetic basis of naive pluripotency maintenance and loss is a central question in embryonic stem cell biology. Here, we deploy CRISPR-knockout-based screens in mouse embryonic stem cells to interrogate this question through a genome-wide
Externí odkaz:
https://doaj.org/article/aee341e07bbd433b9251e8cbce2f87dc
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Genome-wide CRISPR-based knockout (CRISPR-KO) screening is an emerging technique which enables systematic genetic analysis of a cellular or molecular phenotype in question. Continuous improvements, such as modifications to the guide RNA (gRN
Externí odkaz:
https://doaj.org/article/bf61f265b7c34397b4f245df7adcb64e
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-13 (2017)
Abstract Background Interferon inducible transmembrane (IFITM) proteins are effectors of the immune system widely characterized for their role in restricting infection by diverse enveloped and non-enveloped viruses. The chicken IFITM (chIFITM) genes
Externí odkaz:
https://doaj.org/article/554cc4ce6d0642428a27ed0cc93252cb
Autor:
François Blanquart, Chris Wymant, Marion Cornelissen, Astrid Gall, Margreet Bakker, Daniela Bezemer, Matthew Hall, Mariska Hillebregt, Swee Hoe Ong, Jan Albert, Norbert Bannert, Jacques Fellay, Katrien Fransen, Annabelle J Gourlay, M Kate Grabowski, Barbara Gunsenheimer-Bartmeyer, Huldrych F Günthard, Pia Kivelä, Roger Kouyos, Oliver Laeyendecker, Kirsi Liitsola, Laurence Meyer, Kholoud Porter, Matti Ristola, Ard van Sighem, Guido Vanham, Ben Berkhout, Paul Kellam, Peter Reiss, Christophe Fraser, BEEHIVE collaboration
Publikováno v:
PLoS Biology, Vol 15, Iss 7, p e1002608 (2017)
[This corrects the article DOI: 10.1371/journal.pbio.2001855.].
Externí odkaz:
https://doaj.org/article/e19b163648b5491ca46d82a597c41509
Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe.
Autor:
François Blanquart, Chris Wymant, Marion Cornelissen, Astrid Gall, Margreet Bakker, Daniela Bezemer, Matthew Hall, Mariska Hillebregt, Swee Hoe Ong, Jan Albert, Norbert Bannert, Jacques Fellay, Katrien Fransen, Annabelle J Gourlay, M Kate Grabowski, Barbara Gunsenheimer-Bartmeyer, Huldrych F Günthard, Pia Kivelä, Roger Kouyos, Oliver Laeyendecker, Kirsi Liitsola, Laurence Meyer, Kholoud Porter, Matti Ristola, Ard van Sighem, Guido Vanham, Ben Berkhout, Paul Kellam, Peter Reiss, Christophe Fraser, BEEHIVE collaboration
Publikováno v:
PLoS Biology, Vol 15, Iss 6, p e2001855 (2017)
HIV-1 set-point viral load-the approximately stable value of viraemia in the first years of chronic infection-is a strong predictor of clinical outcome and is highly variable across infected individuals. To better understand HIV-1 pathogenesis and th
Externí odkaz:
https://doaj.org/article/f98f40957ad84cf19a74465399515bff
Autor:
Matthew Cotten, Simon J. Watson, Alimuddin I. Zumla, Hatem Q. Makhdoom, Anne L. Palser, Swee Hoe Ong, Abdullah A. Al Rabeeah, Rafat F. Alhakeem, Abdullah Assiri, Jaffar A. Al-Tawfiq, Ali Albarrak, Mazin Barry, Atef Shibl, Fahad A. Alrabiah, Sami Hajjar, Hanan H. Balkhy, Hesham Flemban, Andrew Rambaut, Paul Kellam, Ziad A. Memish
Publikováno v:
mBio, Vol 5, Iss 1 (2014)
ABSTRACT The Middle East respiratory syndrome coronavirus (MERS-CoV) was first documented in the Kingdom of Saudi Arabia (KSA) in 2012 and, to date, has been identified in 180 cases with 43% mortality. In this study, we have determined the MERS-CoV e
Externí odkaz:
https://doaj.org/article/56fc0730f1bf408fa17fe783becde606
Autor:
Long Truong Hoang, Thomas Tolfvenstam, Eng Eong Ooi, Chiea Chuen Khor, Ahmand Nazri Mohamed Naim, Eliza Xin Pei Ho, Swee Hoe Ong, Heiman F Wertheim, Annette Fox, Chau Van Vinh Nguyen, Ngoc My Nghiem, Tuan Manh Ha, Anh Thi Ngoc Tran, Paul Tambayah, Raymond Lin, Chariya Sangsajja, Weerawat Manosuthi, Chareon Chuchottaworn, Piamlarp Sansayunh, Tawee Chotpitayasunondh, Piyarat Suntarattiwong, Kulkanya Chokephaibulkit, Pilaipan Puthavathana, Menno D de Jong, Jeremy Farrar, H Rogier van Doorn, Martin Lloyd Hibberd
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111640 (2014)
The influenza A virus is an RNA virus that is responsible for seasonal epidemics worldwide with up to five million cases of severe illness and 500,000 deaths annually according to the World Health Organization estimates. The factors associated with s
Externí odkaz:
https://doaj.org/article/721c5ac7ea8b4dca80771467ae2821e3