Regulation of SPDEF expression by DNA methylation in advanced prostate cancer

Autor: Mousa Vatanmakanian, Joshua J. Steffan, Sweaty Koul, Augusto C. Ochoa, Lakshmi S. Chaturvedi, Hari K. Koul

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

IntroductionProstate cancer (PCa) presents a significant health challenge in men, with a substantial number of deaths attributed to metastatic castration resistant PCa (mCRPC). Moreover, African American men experience disproportionately high mortali

Externí odkaz: https://doaj.org/article/2462cfd1c7214e0ab9bfd27d0458bdb7

Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis

Autor: Praveen Kumar Jaiswal, Sweaty Koul, Prakash S. T. Shanmugam, Hari K. Koul

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

Abstract eIF4G1, a critical component of the eIF4F complex, is required for cap-dependent mRNA translation, a process necessary for tumor growth and survival. However, the role of eIF4G1 has not been evaluated in Prostate Cancer (PCa). We observed an

Externí odkaz: https://doaj.org/article/a495c3363f0747548755798c999d741f

Genome wide analysis of differentially expressed genes in HK-2 cells, a line of human kidney epithelial cells in response to oxalate.

Autor: Sweaty Koul, Lakshmipathi Khandrika, Randall B Meacham, Hari K Koul

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e43886 (2012)

Nephrolithiasis is a multi-factorial disease which, in the majority of cases, involves the renal deposition of calcium oxalate. Oxalate is a metabolic end product excreted primarily by the kidney. Previous studies have shown that elevated levels of o

Externí odkaz: https://doaj.org/article/2b39d58615684d3a8f56a3831bfc5c9e

Hippo pathway: Regulation, deregulation and potential therapeutic targets in cancer

Autor: Suman Mohajan, Mousa Vatanmakarian, Hassan Yousefi, Sweaty Koul, Suresh K. Alahari, Hari K. Koul, Praveen Kumar Jaiswal, Saikolappan Sankaralingam

Publikováno v: Cancer Letters. 507:112-123

Hippo pathway is a master regulator of development, cell proliferation, stem cell function, tissue regeneration, homeostasis, and organ size control. Hippo pathway relays signals from different extracellular and intracellular events to regulate cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e81b64619efd1307336326f50e97ca
https://doi.org/10.1016/j.canlet.2021.03.006

Targeting ROS Induced Epigenetic Reprograming in Cancer Stem Cells

Autor: Hari K. Koul, Sankaralingam Saikolappan, Binod Kumar, Sweaty Koul

Publikováno v: Handbook of Oxidative Stress in Cancer: Therapeutic Aspects ISBN: 9789811612473
Handbook of Oxidative Stress in Cancer: Therapeutic Aspects ISBN: 9789811654213

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6837775852a3d10f8dbec82c81d1d813
https://doi.org/10.1007/978-981-16-1247-3_69-1