Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Swati S. More"'
Autor:
Prakashkumar Dobariya, Wei Xie, Swetha Pavani Rao, Jiashu Xie, Davis M. Seelig, Robert Vince, Michael K. Lee, Swati S. More
Publikováno v:
Antioxidants, Vol 13, Iss 6, p 648 (2024)
Acetaminophen (APAP) overdose triggers a cascade of intracellular oxidative stress events, culminating in acute liver injury. The clinically used antidote, N-acetylcysteine (NAC), has a narrow therapeutic window, and early treatment is essential for
Externí odkaz:
https://doaj.org/article/9fb84ff3da554c948f9bac169c7b0010
Autor:
Swetha Pavani Rao, Wei Xie, Ye In Christopher Kwon, Nicholas Juckel, Jiashu Xie, Venkateshwara Rao Dronamraju, Robert Vince, Michael K. Lee, Swati S. More
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102484- (2022)
Increased oxidative stress and inflammation are implicated in the pathogenesis of Alzheimer's disease. Treatment with hydrogen sulfide (H2S) and H2S donors such as sodium hydrosulfide (NaSH) can reduce oxidative stress in preclinical studies, however
Externí odkaz:
https://doaj.org/article/1e8daa17a2394f29ba0ba9ad60e0ab95
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 603 (2023)
3-mercaptopyruvate sulfurtransferase (3-MST) plays the important role of producing hydrogen sulfide. Conserved from bacteria to Mammalia, this enzyme is localized in mitochondria as well as the cytoplasm. 3-MST mediates the reaction of 3-mercaptopyru
Externí odkaz:
https://doaj.org/article/87e2fb3282f44f6c9029638b3e493a47
Autor:
Abbas Raza, Wei Xie, Kwan-Hyun Kim, Venkateshwara Rao Dronamraju, Jessica Williams, Robert Vince, Swati S. More
Publikováno v:
Antioxidants, Vol 11, Iss 6, p 1075 (2022)
Supplementation of glutathione (GSH) levels through varying formulations or precursors has thus far appeared to be a tenable strategy to ameliorate disease-associated oxidative stress. Metabolic liability of GSH and its precursors, i.e., hydrolysis b
Externí odkaz:
https://doaj.org/article/54b235de56224df7a0b4e8cc4ea57df8
Autor:
Ye In Christopher Kwon, Wei Xie, Haizhou Zhu, Jiashu Xie, Keaton Shinn, Nicholas Juckel, Robert Vince, Swati S. More, Michael K. Lee
Publikováno v:
Antioxidants, Vol 10, Iss 11, p 1796 (2021)
Oxidative stress in Alzheimer’s disease (AD) is mediated, in part, by the loss of glutathione (GSH). Previous studies show that γ-glutamyl transpeptidase (GGT)-resistant GSH analog, Ψ-GSH, improves brain GSH levels, reduces oxidative stress marke
Externí odkaz:
https://doaj.org/article/2cdccac0ab3f4519869f07119d79c7b7
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 348-353 (2016)
Glyoxalases prevent the formation of advanced glycation end products by converting glycolysis-derived methylglyoxal to d-lactate with the help of glutathione. Vander Jagt and colleagues previously showed that erythrocytes release about thirty times m
Externí odkaz:
https://doaj.org/article/61dfe1637f08437b8a83b34c958f9f61
Autor:
Wei Xie, Bin Cao, Haizhou Zhu, Abbas Raza, Nicholas Juckel, Jiashu Xie, Rongrong Jiang, Robert Vince, Michael K. Lee, Swati S. More
Publikováno v:
Journal of Medicinal Chemistry. 65:14441-14455
Addressing glycation-induced oxidative stress in Alzheimer's disease (AD) is an emerging pharmacotherapeutic strategy. Restoration of the brain glyoxalase enzyme system that neutralizes reactive dicarbonyls is one such approach. Toward this end, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d455796acb43d48315ca22ac8fd5914d
https://doi.org/10.1021/acs.jmedchem.2c00779
https://doi.org/10.1021/acs.jmedchem.2c00779
Autor:
Kathleen M. Giacomini, Katherine K. Matthay, Steven G. DuBois, Daphne A. Haas-Kogan, Sabine Mueller, William A. Weiss, Henry F. VanBrocklin, Youngho Seo, Michelle K. Tadano, Ethan G. Geier, Xiaodong Yang, Melissa Itsara, Swati S. More
Supplementary Figures S1-S6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a16a1d9af66a155f8b36657648e12e
https://doi.org/10.1158/1078-0432.22442561
https://doi.org/10.1158/1078-0432.22442561
Autor:
Kathleen M. Giacomini, David M. Jablons, Zhidong Xu, Ligong Chen, Sook Wah Yee, Shuanglian Li, Swati S. More
Picoplatin, a third-generation platinum agent, is efficacious against lung cancers that are otherwise resistant or become refractory during platinum treatment. This effort was aimed at the determination of the influence of organic cation transporters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf799c78f4dcc9ba8e808631dee99f74
https://doi.org/10.1158/1535-7163.c.6531783
https://doi.org/10.1158/1535-7163.c.6531783
Autor:
Kathleen M. Giacomini, Katherine K. Matthay, Steven G. DuBois, Daphne A. Haas-Kogan, Sabine Mueller, William A. Weiss, Henry F. VanBrocklin, Youngho Seo, Michelle K. Tadano, Ethan G. Geier, Xiaodong Yang, Melissa Itsara, Swati S. More
Purpose: Histone deacetylase (HDAC) inhibition causes transcriptional activation or repression of several genes that in turn can influence the biodistribution of other chemotherapeutic agents. Here, we hypothesize that the combination of vorinostat,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844c351f6d9aa54d80f79fb28959b053
https://doi.org/10.1158/1078-0432.c.6519260.v1
https://doi.org/10.1158/1078-0432.c.6519260.v1