Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Swati S Jain"'
Autor:
Cynthia Monaco, Jamie Whitfield, Swati S Jain, Lawrence L Spriet, Arend Bonen, Graham P Holloway
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126122 (2015)
Exercise has been shown to induce the translocation of fatty acid translocase (FAT/CD36), a fatty acid transport protein, to both plasma and mitochondrial membranes. While previous studies have examined signals involved in the induction of FAT/CD36 t
Externí odkaz:
https://doaj.org/article/317b42c79e8c48d1ac84a3bed701af6a
Autor:
Michael S Davis, Arend Bonen, Laelie A Snook, Swati S Jain, Kenneth Bartels, Raymond Geor, Karsten Hueffer
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103087 (2014)
Endurance exercise relies on transsarcolemmal flux of substrates in order to avoid depletion of intramuscular reserves. Previous studies of endurance trained sled dogs have shown a remarkable capacity of these dogs to adapt rapidly to endurance exerc
Externí odkaz:
https://doaj.org/article/52851fb822b643e3ba5300af4573379c
Autor:
Graham P. Holloway, James G. Nickerson, James S.V. Lally, Heather L. Petrick, Kaitlyn M.J.H. Dennis, Swati S. Jain, Hakam Alkhateeb, Arend Bonen
Publikováno v:
American Journal of Physiology-Cell Physiology. 322:C546-C553
We aimed to determine the combined effects of overexpressing plasma membrane fatty acid binding protein (FABPpm) and fatty acid translocase (CD36) on skeletal muscle fatty acid transport to establish if these transport proteins function collaborative
Autor:
Gregory R. Steinberg, Paula M. Miotto, Eric A.F. Herbst, Genevieve Simnett, Jamie Whitfield, Holly Robson, Brennan K. Smith, David J. Dyck, Sabina Paglialunga, Graham P. Holloway, Lawrence L. Spriet, Swati S. Jain, Eric M. Desjardins
Publikováno v:
Journal of Biological Chemistry. 292:16653-16664
TBC1 domain family member 1 (TBC1D1), a Rab GTPase-activating protein and paralogue of Akt substrate of 160 kDa (AS160), has been implicated in both insulin- and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase-media
Autor:
Swati S. Jain, Iman Momken, Jan F. C. Glatz, Joost J. F. P. Luiken, Miranda Nabben, Adrian Chabowski, Ellen Dirkx, Jay T. McFarlan, Arend Bonen
Publikováno v:
Biochemical Journal, 474(1), 149-162. Portland Press Ltd.
Biochemical Journal
Biochemical Journal, 2017, 474 (1), pp.149-162. ⟨10.1042/BCJ20160804⟩
Biochemical Journal
Biochemical Journal, 2017, 474 (1), pp.149-162. ⟨10.1042/BCJ20160804⟩
International audience; Leptin stimulates fatty acid oxidation in muscle and heart; but, the mechanism by which these tissues provide additional intracellular fatty acids for their oxidation remains unknown. We examined, in isolated muscle and cardia
Autor:
Adrian Chabowski, Joost J. F. P. Luiken, Swati S. Jain, James S. V. Lally, Ewa Harasim, Elizabeth D. Pask, Yuko Yoshida, Arend Bonen, Kathryn H. Buddo, David C. Wright, Jan F. C. Glatz, Laelie A. Snook, Xiao-Xia Han, Sabina Paglialunga, Marie-Soleil Beaudoin, Graham P. Holloway
Publikováno v:
Diabetologia, 58(10), 2381-2391. Springer, Cham
Aims/hypothesis The mechanisms for diet-induced intramyocellular lipid accumulation and its association with insulin resistance remain contentious. In a detailed time-course study in rats, we examined whether a high-fat diet increased intramyocellula
Autor:
Joost J. F. P. Luiken, Arend Bonen, Jan F. C. Glatz, Laelie A. Snook, Graham P. Holloway, Swati S. Jain, Xiao-Xia Han
Publikováno v:
Febs Letters, 589(19), 2769-2775. Elsevier
Muscle contains various fatty acid transporters (CD36, FABPpm, FATP1, FATP4). Physiological stimuli (insulin, contraction) induce the translocation of all four transporters to the sarcolemma to enhance fatty acid uptake similarly to glucose uptake st
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 307:E102-E114
The therapeutic use of polyunsaturated fatty acids (PUFA) in preserving insulin sensitivity has gained interest in recent decades; however, the roles of linoleic acid (LA) and α-linolenic acid (ALA) remain poorly understood. We investigated the effi
Autor:
Graham P. Holloway, Patrick Schrauwen, A.R. Tupling, Eric A.F. Herbst, Sabina Paglialunga, Alison C. Ludzki, Joris Hoeks, J. S. V. Lally, Swati S. Jain, Arend Bonen, Chris Vigna
Publikováno v:
Diabetes, 63(6), 1907-1913. American Diabetes Association
Calcium/calmodulin dependent protein kinase (CaMK) activation induces mitochondrial biogenesis in response to increasing cytosolic calcium concentrations. Calcium leak from the ryanodine receptor is regulated by reactive oxygen species (ROS), which a
Autor:
James Lally, A. Russell Tupling, Brennan K. Smith, Jay T. McFarlan, Ryan A. Sayer, Arend Bonen, Joost J. F. P. Luiken, Yuko Yoshida, Swati S. Jain, Jan F. C. Glatz, X. X. Han, Laelie A. Snook, Adrian Chabowski, Graham P. Holloway
Publikováno v:
Journal of Biological Chemistry, 287(28), 23502-23516. American Society for Biochemistry and Molecular Biology, Inc.
For ∼40 years it has been widely accepted that (i) the exercise-induced increase in muscle fatty acid oxidation (FAO) is dependent on the increased delivery of circulating fatty acids, and (ii) exercise training-induced FAO up-regulation is largely