Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Swati Palit Deb"'
Autor:
Catherine A. Vaughan, Shilpa Singh, Mark A. Subler, Jolene J. Windle, Kazushi Inoue, Elizabeth A. Fry, Raghavendra Pillappa, Steven R. Grossman, Brad Windle, W. Andrew Yeudall, Swati Palit Deb, Sumitra Deb
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The mechanisms of how gain-of-function (GOF) mutant p53 drives carcinogenesis are unclear. Here, the authors show that a GOF mutant p53 requires its transactivation capability to induce mouse lung tumors and this is dependent on PLK3 phosphorylation
Externí odkaz:
https://doaj.org/article/54a056e3c31c4f638609e87d39e9e921
Autor:
Évila Lopes Salles, Sahar Emami Naeini, Hesam Khodadadi, Bidhan Bhandari, Sholeh Rezaee, Edie Threlkeld, Hannah M. Rogers, Vincenzo Costigliola, Alvin V. Terry, David C. Hess, Sumitra Deb, Swati Palit Deb, W. Andrew Yeudall, Jack C. Yu, Lei P. Wang, Babak Baban
Publikováno v:
Human Cell. 36:1204-1210
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::963afed655d9a9ac9bd6469e8665485f
https://doi.org/10.1007/s13577-023-00869-8
https://doi.org/10.1007/s13577-023-00869-8
Supplementary Data from MDM2 Controls the Timely Expression of Cyclin A to Regulate the Cell Cycle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5015eb8767f213ce1d71c02b0619b552
https://doi.org/10.1158/1541-7786.22519303.v1
https://doi.org/10.1158/1541-7786.22519303.v1
Autor:
Steven R. Grossman, Sumitra Deb, Swati Palit Deb, Nitai D. Mukhopadhyay, Priyadarshan K. Damle, Ian M. Love, Rebecca A. Frum
Supplementary figures (1-12) Supplemental Fig. 1. Normalized levels of monoubiquitinated mutant p53 are shown for indicated cell lines analyzed in Fig. 1a. Supplemental Fig. 2. Longer single exposure of p53 blot in Fig. 2a is displayed to demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f01c827b6d04c09c47697d661de1324
https://doi.org/10.1158/1541-7786.22512204.v1
https://doi.org/10.1158/1541-7786.22512204.v1
Autor:
Steven R. Grossman, Sumitra Deb, Swati Palit Deb, Nitai D. Mukhopadhyay, Priyadarshan K. Damle, Ian M. Love, Rebecca A. Frum
Supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01add0cf5d50c08869e88b8ae920de15
https://doi.org/10.1158/1541-7786.22512201.v1
https://doi.org/10.1158/1541-7786.22512201.v1
Autor:
Steven R. Grossman, Sumitra Deb, Swati Palit Deb, Nitai D. Mukhopadhyay, Priyadarshan K. Damle, Ian M. Love, Rebecca A. Frum
Many mutant p53 proteins exhibit an abnormally long half-life and overall increased abundance compared with wild-type p53 in tumors, contributing to mutant p53's gain-of-function oncogenic properties. Here, a novel mechanism is revealed for the maint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325667192bcbab8aff2317650c7d1a35
https://doi.org/10.1158/1541-7786.c.6540168.v1
https://doi.org/10.1158/1541-7786.c.6540168.v1
Autor:
Shilpa Singh, Brad Windle, Sumitra Deb, Elizabeth A. Fry, Jolene J. Windle, W. Andrew Yeudall, Kazushi Inoue, Swati Palit Deb, Catherine A. Vaughan, Steven R. Grossman, Mark A. Subler, Raghavendra Pillappa
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
p53 mutations with single amino acid changes in cancer often lead to dominant oncogenic changes. Here, we have developed a mouse model of gain-of-function (GOF) p53-driven lung cancer utilizing conditionally active LSL p53-R172H and LSL K-Ras-G12D kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3001552fe338f8bbf14360dc3fb8e02d
http://europepmc.org/articles/PMC7846773
http://europepmc.org/articles/PMC7846773
Autor:
Catherine A. Vaughan, Shilpa Singh, Swati Palit Deb, Sumitra Deb, Steven R. Grossman, Rebecca Frum
Publikováno v:
Journal of Clinical Investigation. 127:1839-1855
Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression. While some of the genes induced by GOF p53 have been implicated in more rapid cell prolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347785aaec3a5ca15511c0086ea995cb
https://doi.org/10.1172/jci87724
https://doi.org/10.1172/jci87724
Autor:
Swati Palit Deb, Ross B. Mikkelsen, Christopher S. Rabender, Sumitra Deb, Catherine A. Vaughan, Shilpa Singh
Publikováno v:
JCI Insight. 4
Depletion of epithelial cells after lung injury prompts proliferation and epithelial mesenchymal transition (EMT) of progenitor cells, and this repopulates the lost epithelial layer. To investigate the cell proliferative function of human oncoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb375be87fee72eaf212157588c1c57
https://doi.org/10.1172/jci.insight.128194
https://doi.org/10.1172/jci.insight.128194
Publikováno v:
Oncotarget
Gain-of-function mutant p53 is thought to induce gene expression in part by binding transcription factors bound to promoters for genes that mediate oncogenesis. We investigated the mechanism of mutant p53 binding by mapping the human genomic binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7216c48fcb34f17ba84cd35a9f4ecd55
http://europepmc.org/articles/PMC3964217
http://europepmc.org/articles/PMC3964217