Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Swathi K. Hullugundi"'
Autor:
Swathi K. Hullugundi, Jennifer Dolkas, Andrei V. Chernov, Tony L. Yaksh, Kelly A. Eddinger, Mila Angert, Glaucilene Ferreira Catroli, Alex Y. Strongin, Patrick M. Dougherty, Yan Li, Oswal Quehenberger, Aaron Armando, Veronica I. Shubayev
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 38, Iss , Pp 100757- (2024)
Background: A bioactive myelin basic protein (MBP) fragment, comprising MBP84-104, is released in sciatic nerve after chronic constriction injury (CCI). Intraneural injection (IN) of MBP84-104 in an intact sciatic nerve is sufficient to induce persis
Externí odkaz:
https://doaj.org/article/8207210de5484313ba8d5ab4ba1522be
Autor:
Hee Jong Lee, Albert G. Remacle, Swathi K. Hullugundi, Jennifer Dolkas, Jake B. Leung, Andrei V. Chernov, Tony L. Yaksh, Alex Y. Strongin, Veronica I. Shubayev
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Immunotherapy holds promise as a non-addictive treatment of refractory chronic pain states. Increasingly, sex is recognized to impact immune regulation of pain states, including mechanical allodynia (pain from non-painful stimulation) that follows pe
Externí odkaz:
https://doaj.org/article/7c2bdb3688594f509a6640ace50c6ee8
Autor:
Albert G. Remacle, Swathi K. Hullugundi, Jennifer Dolkas, Mila Angert, Andrei V. Chernov, Alex Y. Strongin, Veronica I. Shubayev
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-10 (2018)
Abstract Background In the peripheral nerve, pro-inflammatory matrix metalloproteinase (MMP)-9 performs essential functions in the acute response to injury. Whether MMP-9 activity contributes to late-phase injury or whether MMP-9 expression or activi
Externí odkaz:
https://doaj.org/article/30adcbf9c51b40b2b607997ec78589a7
Autor:
Hee Jong Lee, Albert G. Remacle, Swathi K. Hullugundi, Jennifer Dolkas, Jake B. Leung, Andrei V. Chernov, Tony L. Yaksh, Alex Y. Strongin, Veronica I. Shubayev
Publikováno v:
Frontiers in cellular neuroscience. 16
Immunotherapy holds promise as a non-addictive treatment of refractory chronic pain states. Increasingly, sex is recognized to impact immune regulation of pain states, including mechanical allodynia (pain from non-painful stimulation) that follows pe
Autor:
Veronica I. Shubayev, Albert G. Remacle, Jake Leung, Hee Jong Lee, Jennifer Dolkas, Alex Y. Strongin, Swathi K. Hullugundi, Tony L. Yaksh, Andrei V. Chernov
Background: Autoantibodies, a hallmark of autoimmune disorders, are thought to contribute to the pathogenesis of chronic pain. Mechanical hypersensitivity is a severe complication of peripheral nerve injury mediated through sex-specific activity of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c575af0e3111de8ada5c3d40e27a5808
https://doi.org/10.21203/rs.3.rs-117432/v1
https://doi.org/10.21203/rs.3.rs-117432/v1
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60677 (2013)
A knock-in (KI) mouse model of FHM-1 expressing the R192Q missense mutation of the Cacna1a gene coding for the α1 subunit of CaV2.1 channels shows, at the level of the trigeminal ganglion, selective functional up-regulation of ATP -gated P2X3 recept
Externí odkaz:
https://doaj.org/article/3b0aee15e58e4ce5b0480b0c33fcc02a
Autor:
Brian P. James, Mila Angert, Swathi K. Hullugundi, Albert G. Remacle, Andrei V. Chernov, Veronica I. Shubayev, Alex Y. Strongin, Tony L. Yaksh, Jennifer Dolkas, Kelly A. Eddinger
Publikováno v:
J Biol Chem
In the peripheral nerve, mechanosensitive axons are insulated by myelin, a multilamellar membrane formed by Schwann cells. Here, we offer first evidence that a myelin degradation product induces mechanical hypersensitivity and global transcriptomics
Autor:
Albert G. Remacle, Piotr Cieplak, Jennifer Dolkas, Andrei V. Chernov, Veronica I. Shubayev, Mila Angert, Swathi K. Hullugundi, Alex Y. Strongin, David Scott
Publikováno v:
Biochemical Journal. 475:2355-2376
In demyelinating nervous system disorders, myelin basic protein (MBP), a major component of the myelin sheath, is proteolyzed and its fragments are released in the neural environment. Here, we demonstrated that, in contrast with MBP, the cellular upt
Autor:
Veronica I. Shubayev, Swathi K. Hullugundi, Alex Y. Strongin, Albert G. Remacle, Jennifer Dolkas, Andrei V. Chernov, R. Carter W. Jones, Mila Angert
Publikováno v:
Journal of Immunological Methods. 455:80-87
Sciatic nerve chronic constriction injury (CCI) in rodents produces nerve demyelination via proteolysis of myelin basic protein (MBP), the major component of myelin sheath. Proteolysis releases the cryptic MBP epitope, a demyelination marker, which i
Autor:
Swathi K. Hullugundi, Jennifer Dolkas, Veronica I. Shubayev, Albert G. Remacle, Mila Angert, Alex Y. Strongin, Andrei V. Chernov, Piotr Cieplak
Publikováno v:
The FEBS journal. 285(18)
Neurotrauma frequently results in neuropathic pain. Our earlier studies revealed that peripheral neurotrauma-induced fragmentation of the myelin basic protein (MBP), a major component of the myelin sheath formed by Schwann cells, initiates a pain res