Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Swathi K. Hullugundi"'
Autor:
Swathi K. Hullugundi, Jennifer Dolkas, Andrei V. Chernov, Tony L. Yaksh, Kelly A. Eddinger, Mila Angert, Glaucilene Ferreira Catroli, Alex Y. Strongin, Patrick M. Dougherty, Yan Li, Oswal Quehenberger, Aaron Armando, Veronica I. Shubayev
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 38, Iss , Pp 100757- (2024)
Background: A bioactive myelin basic protein (MBP) fragment, comprising MBP84-104, is released in sciatic nerve after chronic constriction injury (CCI). Intraneural injection (IN) of MBP84-104 in an intact sciatic nerve is sufficient to induce persis
Externí odkaz:
https://doaj.org/article/8207210de5484313ba8d5ab4ba1522be
Autor:
Hee Jong Lee, Albert G. Remacle, Swathi K. Hullugundi, Jennifer Dolkas, Jake B. Leung, Andrei V. Chernov, Tony L. Yaksh, Alex Y. Strongin, Veronica I. Shubayev
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Immunotherapy holds promise as a non-addictive treatment of refractory chronic pain states. Increasingly, sex is recognized to impact immune regulation of pain states, including mechanical allodynia (pain from non-painful stimulation) that follows pe
Externí odkaz:
https://doaj.org/article/7c2bdb3688594f509a6640ace50c6ee8
Autor:
Albert G. Remacle, Swathi K. Hullugundi, Jennifer Dolkas, Mila Angert, Andrei V. Chernov, Alex Y. Strongin, Veronica I. Shubayev
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-10 (2018)
Abstract Background In the peripheral nerve, pro-inflammatory matrix metalloproteinase (MMP)-9 performs essential functions in the acute response to injury. Whether MMP-9 activity contributes to late-phase injury or whether MMP-9 expression or activi
Externí odkaz:
https://doaj.org/article/30adcbf9c51b40b2b607997ec78589a7
Autor:
Hee Jong Lee, Albert G. Remacle, Swathi K. Hullugundi, Jennifer Dolkas, Jake B. Leung, Andrei V. Chernov, Tony L. Yaksh, Alex Y. Strongin, Veronica I. Shubayev
Publikováno v:
Frontiers in cellular neuroscience. 16
Immunotherapy holds promise as a non-addictive treatment of refractory chronic pain states. Increasingly, sex is recognized to impact immune regulation of pain states, including mechanical allodynia (pain from non-painful stimulation) that follows pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8c7f10d190421ddc5c5b309192d7d1
https://pubmed.ncbi.nlm.nih.gov/35496906
https://pubmed.ncbi.nlm.nih.gov/35496906
Autor:
Veronica I. Shubayev, Albert G. Remacle, Jake Leung, Hee Jong Lee, Jennifer Dolkas, Alex Y. Strongin, Swathi K. Hullugundi, Tony L. Yaksh, Andrei V. Chernov
Background: Autoantibodies, a hallmark of autoimmune disorders, are thought to contribute to the pathogenesis of chronic pain. Mechanical hypersensitivity is a severe complication of peripheral nerve injury mediated through sex-specific activity of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c575af0e3111de8ada5c3d40e27a5808
https://doi.org/10.21203/rs.3.rs-117432/v1
https://doi.org/10.21203/rs.3.rs-117432/v1
Autor:
Brian P. James, Mila Angert, Swathi K. Hullugundi, Albert G. Remacle, Andrei V. Chernov, Veronica I. Shubayev, Alex Y. Strongin, Tony L. Yaksh, Jennifer Dolkas, Kelly A. Eddinger
Publikováno v:
J Biol Chem
In the peripheral nerve, mechanosensitive axons are insulated by myelin, a multilamellar membrane formed by Schwann cells. Here, we offer first evidence that a myelin degradation product induces mechanical hypersensitivity and global transcriptomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631f4ad184e21a62665cef51ce416379
https://pubmed.ncbi.nlm.nih.gov/32532796
https://pubmed.ncbi.nlm.nih.gov/32532796
Autor:
Albert G. Remacle, Piotr Cieplak, Jennifer Dolkas, Andrei V. Chernov, Veronica I. Shubayev, Mila Angert, Swathi K. Hullugundi, Alex Y. Strongin, David Scott
Publikováno v:
Biochemical Journal. 475:2355-2376
In demyelinating nervous system disorders, myelin basic protein (MBP), a major component of the myelin sheath, is proteolyzed and its fragments are released in the neural environment. Here, we demonstrated that, in contrast with MBP, the cellular upt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013debda223a85b5bc4289d1c826880a
https://doi.org/10.1042/bcj20180137
https://doi.org/10.1042/bcj20180137
Autor:
Veronica I. Shubayev, Swathi K. Hullugundi, Alex Y. Strongin, Albert G. Remacle, Jennifer Dolkas, Andrei V. Chernov, R. Carter W. Jones, Mila Angert
Publikováno v:
Journal of Immunological Methods. 455:80-87
Sciatic nerve chronic constriction injury (CCI) in rodents produces nerve demyelination via proteolysis of myelin basic protein (MBP), the major component of myelin sheath. Proteolysis releases the cryptic MBP epitope, a demyelination marker, which i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601b840ed030b59b265be2195aabae9f
https://doi.org/10.1016/j.jim.2018.02.002
https://doi.org/10.1016/j.jim.2018.02.002
Autor:
Swathi K. Hullugundi, Jennifer Dolkas, Veronica I. Shubayev, Albert G. Remacle, Mila Angert, Alex Y. Strongin, Andrei V. Chernov, Piotr Cieplak
Publikováno v:
The FEBS journal. 285(18)
Neurotrauma frequently results in neuropathic pain. Our earlier studies revealed that peripheral neurotrauma-induced fragmentation of the myelin basic protein (MBP), a major component of the myelin sheath formed by Schwann cells, initiates a pain res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f356d226b549ec5980887355ed66c651
https://pubmed.ncbi.nlm.nih.gov/30079618
https://pubmed.ncbi.nlm.nih.gov/30079618
Autor:
Albert G. Remacle, Khatereh Motamedchaboki, Jennifer Dolkas, Sonu Kumar, Veronica I. Shubayev, Swathi K. Hullugundi, Piotr Cieplak, Alex Y. Strongin
Publikováno v:
Journal of Biological Chemistry. 290:22939-22944
Congenital insensitivity to pain (CIP) or congenital analgesia is a rare monogenic hereditary condition. This disorder is characterized by the inability to perceive any form of pain. Nonsense mutations in Nav.1.7, the main pain signaling voltage-gate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff98ba2c15c1211e6d0e432c64d77b56
https://doi.org/10.1074/jbc.c115.671107
https://doi.org/10.1074/jbc.c115.671107