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pro vyhledávání: '"Swathi Banthiya"'
Autor:
You Zhou, Dagmar Heydeck, Maceler Aldrovandi, Sven W. Meckelmann, Valerie B. O'Donnell, Swathi Banthiya, Hartmut Kühn
Publikováno v:
Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids
Pseudomonas aeruginosa is a gram-negative pathogen, which causes life-threatening infections in immunocompromized patients. These bacteria express a secreted lipoxygenase (PA-LOX), which oxygenates free arachidonic acid to 15S-hydro(pero)xyeicosatetr
Autor:
Swathi Banthiya, Mats Hamberg, Jacqueline Kalms, Patrick Scheerer, Xavi Carpena, Hartmut Kühn, Igor Ivanov, Etienne Galemou Yoga
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Pseudomonas aeruginosa expresses a secreted LOX-isoform (PA-LOX, LoxA) capable of oxidizing polyenoic fatty acids to hydroperoxy derivatives. Here we report high-level expression of this enzyme in E. coli and its structural and functional characteriz
Autor:
Swathi Banthiya, Mats Hamberg, Hermann-Georg Holzhütter, Etienne Galemou Yoga, Hartmut Kühn, Patrick Scheerer, Jacqueline Kalms
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1862(5)
Secreted LOX from Pseudomonas aeruginosa (PA-LOX) has previously been identified as arachidonic acid 15S-lipoxygenating enzyme. Here we report that the substitution of Ala420Gly in PA-LOX leads to an enzyme variant with pronounced dual specificity fa
Publikováno v:
Archives of biochemistry and biophysics. 584
Pseudomonas aeruginosa (PA) expresses a secreted lipoxygenase (LOX), which oxygenates free arachidonic acid predominantly to 15S-H(p)ETE. The enzyme is capable of binding phospholipids at its active site and physically interacts with model membranes.
Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which have been implicated not only in cell proliferation and differentiation but also in the pathogenesis of various diseases with major public health relevance. As other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c1939ab003fea63ec99bfe7088d6bd
https://europepmc.org/articles/PMC4370320/
https://europepmc.org/articles/PMC4370320/