Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Swapnil P. Bhujbal"'
1
Akademický článek
An Innovative Approach to Address Neurodegenerative Diseases through Kinase-Targeted Therapies: Potential for Designing Covalent Inhibitors
Autor: Swapnil P. Bhujbal, Jung-Mi Hah
Publikováno v: Pharmaceuticals, Vol 16, Iss 9, p 1295 (2023)
Owing to the dysregulation of protein kinase activity in various diseases such as cancer and autoimmune, cardiovascular, neurodegenerative, and inflammatory conditions, the protein kinase family has emerged as a crucial drug target in the 21st centur
Externí odkaz: https://doaj.org/article/9b71b40e00f14f3d9aee2708d51ea5ab
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2
Akademický článek
An Intriguing Purview on the Design of Macrocyclic Inhibitors for Unexplored Protein Kinases through Their Binding Site Comparison
Autor: Swapnil P. Bhujbal, Jung-Mi Hah
Publikováno v: Pharmaceuticals, Vol 16, Iss 7, p 1009 (2023)
Kinases play an important role in regulating various intracellular signaling pathways that control cell proliferation, differentiation, survival, and other cellular processes, and their deregulation causes more than 400 diseases. Consequently, macroc
Externí odkaz: https://doaj.org/article/4452561643794a278bba195ef60b863c
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3
Akademický článek
Design and Synthesis of Aminopyrimidinyl Pyrazole Analogs as PLK1 Inhibitors Using Hybrid 3D-QSAR and Molecular Docking
Autor: Swapnil P. Bhujbal, Hyejin Kim, Hyunah Bae, Jung-Mi Hah
Publikováno v: Pharmaceuticals, Vol 15, Iss 10, p 1170 (2022)
Cancer continues to be one of the world’s most severe public health issues. Polo-like kinase 1 (PLK1) is one of the most studied members of the polo-like kinase subfamily of serine/threonine protein kinases. PLK1 is a key mitotic regulator responsi
Externí odkaz: https://doaj.org/article/57f14877c7804146b8b398d1be18d9d7
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4
Akademický článek
Design of Novel IRAK4 Inhibitors Using Molecular Docking, Dynamics Simulation and 3D-QSAR Studies
Autor: Swapnil P. Bhujbal, Weijie He, Jung-Mi Hah
Publikováno v: Molecules, Vol 27, Iss 19, p 6307 (2022)
Treatment of several autoimmune diseases and types of cancer has been an intense area of research over the past two decades. Many signaling pathways that regulate innate and/or adaptive immunity, as well as those that induce overexpression or mutatio
Externí odkaz: https://doaj.org/article/274ca3ad17714a35b10adeccccd436bc
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5
Akademický článek
Molecular Modelling Studies on Pyrazole Derivatives for the Design of Potent Rearranged during Transfection Kinase Inhibitors
Autor: Swapnil P. Bhujbal, Seketoulie Keretsu, Seung Joo Cho
Publikováno v: Molecules, Vol 26, Iss 3, p 691 (2021)
RET (rearranged during transfection) kinase, one of the receptor tyrosine kinases, plays a crucial role in the development of the human nervous system. It is also involved in various cell signaling networks responsible for the normal cell division, g
Externí odkaz: https://doaj.org/article/0a722585e6324f23b3473305c5d0e0ab
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6
Design of New Therapeutic Agents Targeting FLT3 Receptor Tyrosine Kinase Using Molecular Docking and 3D-QSAR Approach
Autor: Swapnil P. Bhujbal, Seketoulie Keretsu, Seung Joo Cho
Publikováno v: Letters in Drug Design & Discovery. 17:585-596
Background: FMS-like tyrosine kinase-3 (FLT3) belongs to the class III Receptor Tyrosine Kinase (RTK) family. FLT3 is involved in normal hematopoiesis and is generally expressed in early hematopoietic progenitor cells. Mutations either with an intern
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd83a37dce3fece996f9c6c64fbabd42
https://doi.org/10.2174/1570180816666190618104632
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8
3D-QSAR Assisted Design of Novel 7-Deazapurine Derivatives as TNNI3K Kinase Inhibitors Using Molecular Docking and Molecular Dynamics Simulation
Autor: Pavithra K. Balasubramanian, Swapnil P. Bhujbal, Anand Balupuri, Seung Joo Cho
Publikováno v: Letters in Drug Design & Discovery. 17:155-168
Background: Cardiac troponin I-interacting kinase (TNNI3K) is a cardiac-specific kinase that belongs to MAPKKK family. It is a dual-function kinase with tyrosine and serine/threonine kinase activity. Over-expression of TNNI3K results in various cardi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::512b553e070ed8009e9d3ce996974387
https://doi.org/10.2174/1570180816666190110121300
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9
Molecular modeling studies of pyrrolo[2,3-d]pyrimidin-4-amine derivatives as JAK1 inhibitors based on 3D-QSAR, molecular docking, molecular dynamics (MD) and MM-PBSA calculations
Autor: Swapnil P. Bhujbal, Seketoulie Keretsu, Seung Joo Cho
Publikováno v: Journal of Biomolecular Structure and Dynamics. 39:753-765
Rheumatoid Arthritis (RA) is an autoimmune disease caused by overproduction of pro-inflammatory cytokines. Janus Kinases (JAKs) mediate cytokines signaling through the Janus Kinase (JAK)/signal transducer and activator of transcription (STAT) signali
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d6608dcb047fa465b0ca37d6a3c277
https://doi.org/10.1080/07391102.2020.1714483
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10
Generation of Non-Nucleotide CD73 Inhibitors Using a Molecular Docking and 3D-QSAR Approach
Autor: Jung-Mi Hah, Swapnil P. Bhujbal
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 12745, p 12745 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12745
Radiotherapy and chemotherapy are conventional cancer treatments. Around 60% of all patients who are diagnosed with cancer receive radio- or chemotherapy in combination with surgery during their disease. Only a few patients respond to the blockage of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619565dd32f0221fa1bfe5669a71713b
https://www.mdpi.com/1422-0067/22/23/12745
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