Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Swapnil K. Sonkusare"'
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract The success of lung transplantation is limited by the high rate of primary graft dysfunction due to ischemia-reperfusion injury (IRI). Lung IRI is characterized by a robust inflammatory response, lung dysfunction, endothelial barrier disrupt
Externí odkaz:
https://doaj.org/article/fbd37829100a471980e44bfbb336bf22
Autor:
T. C. Stevenson Keller, Christophe Lechauve, Alexander S. Keller, Gilson Brás Broseghini-Filho, Joshua T. Butcher, Henry R. Askew Page, Aditi Islam, Zhe Yin Tan, Leon J. DeLalio, Steven Brooks, Poonam Sharma, Kwangseok Hong, Wenhao Xu, Alessandra Simão Padilha, Claire A. Ruddiman, Angela K. Best, Edgar Macal, Daniel B. Kim-Shapiro, George Christ, Zhen Yan, Miriam M. Cortese-Krott, Karina Ricart, Rakesh Patel, Timothy P. Bender, Swapnil K. Sonkusare, Mitchell J. Weiss, Hans Ackerman, Linda Columbus, Brant E. Isakson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
In mammals, hypoxia causes dilation of small arteries for increased metabolic demand. Keller et al used novel transgenic mice to show alpha hemoglobin in endothelium, once thought only in red blood cells, can regulate hypoxic-mediated dilation.
Externí odkaz:
https://doaj.org/article/b9f465340f0741ff838bff1e07d81c95
Autor:
Claire A. Ruddiman, Richard Peckham, Melissa A. Luse, Yen-Lin Chen, Maniselvan Kuppusamy, Bruce A. Corliss, P. Jordan Hall, Chien-Jung Lin, Shayn M. Peirce, Swapnil K. Sonkusare, Robert P. Mecham, Jessica E. Wagenseil, Brant E. Isakson
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Lipid regulation of ion channels is largely explored using in silico modeling with minimal experimentation in intact tissue; thus, the functional consequences of these predicted lipid-channel interactions within native cellular environments remain el
Externí odkaz:
https://doaj.org/article/7e3053ea3fba4f4ebcd0e85d89274a84
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/80a84eea716a4df0b9192532ac4a4be3
Autor:
Zdravka Daneva, Yen‐Lin Chen, Huy Q. Ta, Vamsi Manchikalapudi, Abhishek Bazaz, Victor E. Laubach, Swapnil K. Sonkusare
Publikováno v:
Pulmonary Circulation, Vol 13, Iss 1, Pp n/a-n/a (2023)
Abstract Endothelial cells (ECs) from small pulmonary arteries (PAs) release nitric oxide (NO) and prostacyclin, which lower pulmonary arterial pressure (PAP). In pulmonary hypertension (PH), the levels of endothelium‐derived NO and prostacyclin ar
Externí odkaz:
https://doaj.org/article/ed72a83138984a83b11cf07c8e9401ae
Autor:
Yen‐Lin Chen, Swapnil K. Sonkusare
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 4 (2022)
Externí odkaz:
https://doaj.org/article/757b45bf40b04eaf8da5c7762dc8d652
Autor:
Kirsten Jander, Jan Greulich, Stefanie Gonnissen, Niloofar Ale-Agha, Christine Goy, Philipp Jakobs, Sabrina Farrokh, Corina Marziano, Swapnil K. Sonkusare, Judith Haendeler, Joachim Altschmied
Publikováno v:
Antioxidants, Vol 10, Iss 3, p 428 (2021)
We previously demonstrated that the transcription factor Grainyhead-like 3 (GRHL3) has essential functions in endothelial cells by inhibiting apoptosis and promoting migration as well as activation of endothelial nitric oxide synthase (eNOS). We now
Externí odkaz:
https://doaj.org/article/cacda6784fe64f48b1f84bf0b3dd054e
Autor:
Corina Marziano, Kwangseok Hong, Eric L. Cope, Michael I. Kotlikoff, Brant E. Isakson, Swapnil K. Sonkusare
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 12 (2017)
BackgroundRecent studies demonstrate that spatially restricted, local Ca2+ signals are key regulators of endothelium‐dependent vasodilation in systemic circulation. There are drastic functional differences between pulmonary arteries (PAs) and syste
Externí odkaz:
https://doaj.org/article/7411619db45f4a2c8683b244a5559d27
Autor:
Doris Wong, Gaëlle Auguste, Christian L. Lino Cardenas, Adam W. Turner, Yixuan Chen, Yipei Song, Lijiang Ma, R. Noah Perry, Redouane Aherrahrou, Maniselvan Kuppusamy, Chaojie Yang, Jose Verdezoto Mosquera, Collin J. Dube, Mohammad Daud Khan, Meredith Palmore, Jaspreet Kalra, Maryam Kavousi, Patricia A. Peyser, Ljubica Matic, Ulf Hedin, Ani Manichaikul, Swapnil K. Sonkusare, Mete Civelek, Jason C. Kovacic, Johan L.M. Björkegren, Rajeev Malhotra, Clint L. Miller
Publikováno v:
Circulation Research, 132(9), 1144-1161. Lippincott Williams & Wilkins
Background: Genome-wide association studies have identified hundreds of loci associated with common vascular diseases, such as coronary artery disease, myocardial infarction, and hypertension. However, the lack of mechanistic insights for many GWAS l
Autor:
Yen-Lin, Chen, Zdravka, Daneva, Maniselvan, Kuppusamy, Matteo, Ottolini, Thomas M, Baker, Eliska, Klimentova, Soham A, Shah, Jennifer D, Sokolowski, Min S, Park, Swapnil K, Sonkusare
Publikováno v:
Circulation. 146(7)
CaWe used SMC-specific TRPV4We provide first evidence that TRPV4Our data identify novel smooth muscle Ca