Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction

Autor: Alice Braun, Sudhanshu Shekhar, Daniel F. Levey, Peter Straub, Julia Kraft, Georgia M. Panagiotaropoulou, Karl Heilbron, Swapnil Awasthi, Rafael Meleka Hanna, Sarah Hoffmann, Maike Stein, Sophie Lehnerer, Philipp Mergenthaler, Abdelrahman G. Elnahas, Apostolia Topaloudi, Maria Koromina, Teemu Palviainen, Bergrun Asbjornsdottir, Hreinn Stefansson, Astros Th. Skuladóttir, Ingileif Jónsdóttir, Kari Stefansson, Kadri Reis, Tõnu Esko, Aarno Palotie, Frank Leypoldt, Murray B. Stein, Pierre Fontanillas, Estonian Biobank Research Team, andMe Research Team, Jaakko Kaprio, Joel Gelernter, Lea K. Davis, Peristera Paschou, Martijn R. Tannemaat, Jan J.G.M. Verschuuren, Gregor Kuhlenbäumer, Peter K. Gregersen, Maartje G. Huijbers, Frauke Stascheit, Andreas Meisel, Stephan Ripke

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Myasthenia gravis (MG) is a rare autoantibody-mediated disease affecting the neuromuscular junction. We performed a genome-wide association study of 5708 MG cases and 432,028 controls of European ancestry and a replication study in 3989 case

Externí odkaz: https://doaj.org/article/60cf6148fd9f44d284695ed5465db1c0

Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms

Autor: Sonja M. Kagerer, Swapnil Awasthi, Stephan Ripke, Aleksandra Maceski, Pascal Benkert, Aïda B. Fall, Peter Riederer, Peter Fischer, Susanne Walitza, Edna Grünblatt, Jens Kuhle, Paul G. Unschuld

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 1, Pp n/a-n/a (2024)

Abstract INTRODUCTION Establishing valid diagnostic strategies is a precondition for successful therapeutic intervention in Alzheimer's disease (AD). METHODS One hundred forty‐four healthy 75‐year‐old participants from the Vienna‐Transdanube�

Externí odkaz: https://doaj.org/article/66b89bac42f44806ae6552cdfe03993b

Corrigendum: Potential genetic overlap between insomnia and sleep symptoms in major depressive disorder: A polygenic risk score analysis

Autor: Lindsay M. Melhuish Beaupre, Arun K. Tiwari, Vanessa F. Gonçalves, Clement C. Zai, Victoria S. Marshe, Cathryn M. Lewis, Nicholas G. Martin, Andrew M. McIntosh, Mark J. Adams, Bernhard T. Baune, Doug F. Levinson, Dorret I. Boomsma, Brenda W. J. H. Penninx, Gerome Breen, Steve Hamilton, Swapnil Awasthi, Stephan Ripke, Lisa Jones, Ian Jones, Enda M. Byrne, Ian B. Hickie, James P. Potash, Jianxin Shi, Myrna M. Weissman, Yuri Milaneschi, Stanley I. Shyn, Eco J. C. de Geus, Gonneke Willemsen, Gregory M. Brown, James L. Kennedy, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

Publikováno v: Frontiers in Psychiatry, Vol 13 (2022)

Externí odkaz: https://doaj.org/article/a8925d718a424594890882d7833a7b3a

Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes

Autor: Ole Kristian Drange, Olav Bjerkehagen Smeland, Alexey A. Shadrin, Per Ivar Finseth, Aree Witoelar, Oleksandr Frei, Psychiatric Genomics Consortium Bipolar Disorder Working Group, Yunpeng Wang, Sahar Hassani, Srdjan Djurovic, Anders M. Dale, Ole A. Andreassen, Eli A Stahl, Gerome Breen, Andreas J Forstner, Andrew McQuillin, Stephan Ripke, Vassily Trubetskoy, Manuel Mattheisen, Jonathan R I Coleman, Heìleìna A Gaspar, Christiaan A de Leeuw, Stacy Steinberg, Jennifer M Whitehead Pavlides, Maciej Trzaskowski, Tune H Pers, Peter A Holmans, Liam Abbott, Esben Agerbo, Huda Akil, Diego Albani, Ney Alliey-Rodriguez, Thomas D Als, Adebayo Anjorin, Verneri Antilla, Swapnil Awasthi, Judith A Badner, Marie Bækvad-Hansen, Jack D Barchas, Nicholas Bass, Michael Bauer, Richard Belliveau, Sarah E Bergen, Carsten Bøcker Pedersen, Erlend Bøen, Marco Boks, James Boocock, Monika Budde, William Bunney, Margit Burmeister, Jonas Bybjerg-Grauholm, William Byerley, Miquel Casas, Felecia Cerrato, Pablo Cervantes, Kimberly Chambert, Alexander W Charney, Danfeng Chen, Claire Churchhouse, Toni-Kim Clarke, William Coryell, David W Craig, Cristiana Cruceanu, David Curtis, Piotr M Czerski, Anders M Dale, Simone de Jong, Franziska Degenhardt, Jurgen Del-Favero, J Raymond DePaulo, Amanda L Dobbyn, Ashley Dumont, Torbjørn Elvsåshagen, Valentina Escott-Price, Chun Chieh Fan, Sascha B Fischer, Matthew Flickinger, Tatiana M Foroud, Liz Forty, Josef Frank, Christine Fraser, Nelson B Freimer, Louise Friseìn, Katrin Gade, Diane Gage, Julie Garnham, Claudia Giambartolomei, Marianne Giørtz Pedersen, Jaqueline Goldstein, Scott D Gordon, Katherine Gordon-Smith, Elaine K Green, Melissa J Green, Tiffany A Greenwood, Jakob Grove, Weihua Guan, Joseì Guzman Parra, Marian L Hamshere, Martin Hautzinger, Urs Heilbronner, Stefan Herms, Maria Hipolito, Per Hoffmann, Dominic Holland, Laura Huckins, Steìphane Jamain, Jessica S Johnson, Anders Jureìus, Radhika Kandaswamy, Robert Karlsson, James L Kennedy, Sarah Kittel-Schneider, Sarah V Knott, James A Knowles, Manolis Kogevinas, Anna C Koller, Ralph Kupka, Catharina Lavebratt, Jacob Lawrence, William B Lawson, Markus Leber, Phil H Lee, Shawn E Levy, Jun Z Li, Chunyu Liu, Susanne Lucae, Anna Maaser, Donald J MacIntyre, Pamela B Mahon, Wolfgang Maier, Lina Martinsson, Steve McCarroll, Peter McGuffin, Melvin G McInnis, James D McKay, Helena Medeiros, Sarah E Medland, Fan Meng, Lili Milani, Grant W Montgomery, Derek W Morris, Thomas W Mühleisen, Niamh Mullins, Hoang Nguyen, Caroline M Nievergelt, Annelie Nordin Adolfsson, Evaristus A Nwulia, Claire O’Donovan, Loes M Olde Loohuis, Anil P S Ori, Lilijana Oruc, Urban Ösby, Roy H Perlis, Amy Perry, Andrea Pfennig, James B Potash, Shaun M Purcell, Eline J Regeer, Andreas Reif, Ceìline S Reinbold, John P Rice, Fabio Rivas, Margarita Rivera, Panos Roussos, Douglas M Ruderfer, Euijung Ryu, Cristina Saìnchez-Mora, Alan F Schatzberg, William A Scheftner, Nicholas J Schork, Cynthia Shannon Weickert, Tatyana Shehktman, Paul D Shilling, Engilbert Sigurdsson, Claire Slaney, Olav B Smeland, Janet L Sobell, Christine Søholm Hansen, Anne T Spijker, David St Clair, Michael Steffens, John S Strauss, Fabian Streit, Jana Strohmaier, Szabolcs Szelinger, Robert C Thompson, Thorgeir E Thorgeirsson, Jens Treutlein, Helmut Vedder, Weiqing Wang, Stanley J Watson, Thomas W Weickert, Stephanie H Witt, Simon Xi, Wei Xu, Allan H Young, Peter Zandi, Peng Zhang, Sebastian Zollner, Rolf Adolfsson, Ingrid Agartz, Martin Alda, Lena Backlund, Bernhard T Baune, Frank Bellivier, Wade H Berrettini, Joanna M Biernacka, Douglas H R Blackwood, Michael Boehnke, Anders D Børglum, Aiden Corvin, Nicholas Craddock, Mark J Daly, Udo Dannlowski, ToÞnu Esko, Bruno Etain, Mark Frye, Janice M Fullerton, Elliot S Gershon, Michael Gill, Fernando Goes, Maria Grigoroiu-Serbanescu, Joanna Hauser, David M Hougaard, Christina M Hultman, Ian Jones, Lisa A Jones, Reneì S Kahn, George Kirov, Mikael Landeìn, Marion Leboyer, Cathryn M Lewis, Qingqin S Li, Jolanta Lissowska, Nicholas G Martin, Fermin Mayoral, Susan L McElroy, Andrew M McIntosh, Francis J McMahon, Ingrid Melle, Andres Metspalu, Philip B Mitchell, Gunnar Morken, Ole Mors, Preben Bo Mortensen, Bertram Müller-Myhsok, Richard M Myers, Benjamin M Neale, Vishwajit Nimgaonkar, Merete Nordentoft, Markus M Nöthen, Michael C O’Donovan, Ketil J Oedegaard, Michael J Owen, Sara A Paciga, Carlos Pato, Michele T Pato, Danielle Posthuma, Josep Antoni Ramos-Quiroga, Marta Ribaseìs, Marcella Rietschel, Guy A Rouleau, Martin Schalling, Peter R Schofield, Thomas G Schulze, Alessandro Serretti, Jordan W Smoller, Hreinn Stefansson, Kari Stefansson, Eystein Stordal, Patrick F Sullivan, Gustavo Turecki, Arne E Vaaler, Eduard Vieta, John B Vincent, Thomas Werge, John I Nurnberger, Naomi R Wray, Arianna Di Florio, Howard J Edenberg, Sven Cichon, Roel A Ophoff, Laura J Scott, Ole A Andreassen, John Kelsoe, Pamela Sklar

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD and BIP are related. Howev

Externí odkaz: https://doaj.org/article/86fd88785b5745c79b1fba01a8b863d5

Polygenetic risk scores and phenotypic constellations of obsessive–compulsive disorder in clozapine-treated schizophrenia

Autor: Carla Lou Morgenroth, Philipp Kleymann, Stephan Ripke, Swapnil Awasthi, Elias Wagner, Tatiana Oviedo-Salcedo, Cynthia Okhuijsen-Pfeifer, Jurjen J. Luykx, Marte Z. van der Horst, Alkomiet Hasan, Felix Bermpohl, Stefan Gutwinski, Stefanie Schreiter

Obsessive–compulsive symptoms (OCS) are frequently observed in individuals with schizophrenia (SCZ) treated with clozapine (CLZ). This study aimed to analyze prevalence of OCS and obsessive–compulsive disorder (OCD) in this subgroup and find poss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781331bc7f76506b8ce8e874da7a5c54
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/104597