Výsledky vyhledávání - "Swapna Vaddi"

Akademický článek

Identification and Evaluation of Improved 4′-O-(Alkyl) 4,5-Disubstituted 2-Deoxystreptamines as Next-Generation Aminoglycoside Antibiotics

Autor: Stefan Duscha, Heithem Boukari, Dimitri Shcherbakov, Sumantha Salian, Sandrina Silva, Ann Kendall, Takayuki Kato, Rashid Akbergenov, Deborah Perez-Fernandez, Bruno Bernet, Swapna Vaddi, Pia Thommes, Jochen Schacht, David Crich, Andrea Vasella, Erik C. Böttger

Publikováno v: mBio, Vol 5, Iss 5 (2014)

ABSTRACT The emerging epidemic of drug resistance places the development of efficacious and safe antibiotics in the spotlight of current research. Here, we report the design of next-generation aminoglycosides. Discovery efforts were driven by rationa

Externí odkaz: https://doaj.org/article/e75ab41e6d784ecd8f204ed86b0f4019

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Identification and Evaluation of Improved 4′- O -(Alkyl) 4,5-Disubstituted 2-Deoxystreptamines as Next-Generation Aminoglycoside Antibiotics

Autor: Heithem Boukari, Ann Kendall, Sandrina Silva, Stefan Duscha, Jochen Schacht, Dimitri Shcherbakov, Andrea Vasella, Rashid Akbergenov, Sumanth R. Salian, Pia Thommes, Erik C. Böttger, Bruno Bernet, Takayuki Kato, Swapna Vaddi, Déborah Perez-Fernandez, David Crich

Publikováno v: mBio, Vol 5, Iss 5 (2014)
mBio, 5 (5)
mBio

The emerging epidemic of drug resistance places the development of efficacious and safe antibiotics in the spotlight of current research. Here, we report the design of next-generation aminoglycosides. Discovery efforts were driven by rational synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f646840bb9943c77d565c269d29a07
https://journals.asm.org/doi/10.1128/mBio.01827-14

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4'-O-substitutions determine selectivity of aminoglycoside antibiotics

Autor: Venki Ramakrishnan, Ng Chyan Leong, Déborah Perez-Fernandez, Erik C. Böttger, Rashid Akbergenov, Pia Thommes, Stefan Duscha, Pietro Freihofer, Kathrin Lang, Iwona Kudyba, Rashmi Patak, Heithem Boukari, Andrea Vasella, Dmitri Shcherbakov, Swapna Vaddi, Martin Meyer, Srinivas Reddy Dubbaka, Tanja Matt

Publikováno v: Nature Communications
Nature Communications, 5
'Nature Communications ', vol: 5, pages: 3112-1-3112-11 (2014)

Clinical use of 2-deoxystreptamine aminoglycoside antibiotics, which target the bacterial ribosome, is compromised by adverse effects related to limited drug selectivity. Here we present a series of 4′,6′-O-acetal and 4′-O-ether modifications o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b71fe7a3a8bc8e94176d07fcabb270d
https://pubmed.ncbi.nlm.nih.gov/24473108

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Comparison of key interhemispheric connections and the posterior commissure in normal and hydrocephalic rat fetuses

Autor: Carys M. Bannister, Sajida Rasul, Andrew J. Shepherd, Sarah Cains, Swapna Vaddi

Publikováno v: Cerebrospinal Fluid Research, Vol 6, Iss Suppl 1, p S8 (2009)

Background There are a surprising number of interconnecting fibre tracts linking the two cerebral hemispheres, the largest of these being the corpus callosum, but the hippocampal and anterior commissures are also sizable structures. The posterior com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c03782829d322b5684a0e7dfbcaa508

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