Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Swapan K, Chowdhury"'
Autor:
Jayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan, Swapan K. Chowdhury
Publikováno v:
Drug Metabolism and Disposition. 50:989-997
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a975e4ec44c63b0aae328edd588a82c
https://doi.org/10.1124/dmd.122.000842
https://doi.org/10.1124/dmd.122.000842
Publikováno v:
Drug Metabolism and Disposition. 50:716-724
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb06d9fb461ceb6a740325f61048c012
https://doi.org/10.1124/dmd.122.000832
https://doi.org/10.1124/dmd.122.000832
Autor:
Sandeepraj Pusalkar, Swapan K. Chowdhury, Richard Czerniak, Xiaochun Zhu, Yuexian Li, Suresh K. Balani, Diane Ramsden
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 47:371-386
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d2609436f1ae1ba7572573b89e6a099
https://doi.org/10.1007/s13318-021-00751-8
https://doi.org/10.1007/s13318-021-00751-8
Autor:
Philip, Sandoval, Bei-Ching, Chuang, John K, Fallon, Philip C, Smith, Swapan K, Chowdhury, Robert J, Griffin, Cindy Q, Xia, Shinji, Iwasaki, Paresh P, Chothe
Publikováno v:
The AAPS journal. 24(6)
The liver is central to the elimination of many drugs from the body involving multiple processes and understanding of these processes is important to quantitively assess hepatic clearance of drugs. The synthetic STING (STimulator of INterferon Genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a26f47579196577f58f52183c4d0089
https://pubmed.ncbi.nlm.nih.gov/36123502
https://pubmed.ncbi.nlm.nih.gov/36123502
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 50(5)
Glucuronidation is the most common phase II metabolic pathway to eliminate small molecule drugs from the body. However, determination of glucuronide structure is quite challenging by mass spectrometry due to its inability to generate structure-inform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b6a26e67d42880ab14b350fa4ff36973
https://pubmed.ncbi.nlm.nih.gov/35241454
https://pubmed.ncbi.nlm.nih.gov/35241454
Autor:
Sandeepraj, Pusalkar, Swapan K, Chowdhury, Richard, Czerniak, Xiaochun, Zhu, Yuexian, Li, Suresh K, Balani, Diane, Ramsden
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 47(3)
Felcisetrag (previously TAK-954 or TD-8954) is a highly selective and potent 5-HTThe metabolism and victim and perpetrator drug interaction potentials towards cytochrome P450s (CYP) and transporters were determined using in vitro models. The excretio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d29e47f55e0a8848623643c738a68cc8
https://pubmed.ncbi.nlm.nih.gov/35157234
https://pubmed.ncbi.nlm.nih.gov/35157234
Autor:
Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury, Paresh P. Chothe
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 50(7)
Quantitative assessment of hepatic clearance (CL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8de9e5d222588a1c44038f7389db84d
https://pubmed.ncbi.nlm.nih.gov/35545257
https://pubmed.ncbi.nlm.nih.gov/35545257
Autor:
Jayaprakasam, Bolleddula, Abhi, Shah, Mohammad, Shadid, Afrand, Kamali, Michael D, Smith, Swapan K, Chowdhury
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(11)
TAK-164 is an antibody-drug conjugate (ADC) comprising human anti-guanylyl cyclase C (GCC) monoclonal antibody conjugated to indolinobenzodiazepine DNA alkylator IGN-P1 through a cleavable alanine-alanine dipeptide linker. TAK-164 is currently being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5422710b88bcfd72f2a23ac6138637a8
https://pubmed.ncbi.nlm.nih.gov/32843329
https://pubmed.ncbi.nlm.nih.gov/32843329
Publikováno v:
Drug Metabolism and Disposition. 46:1692-1702
The kidney is a major clearance organ of the body and is responsible for the elimination of many xenobiotics and prescription drugs. With its multitude of uptake and efflux transporters and metabolizing enzymes, the proximal tubule cell (PTC) in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f778989faf66e4baf22054f0db46d7
https://doi.org/10.1124/dmd.118.082958
https://doi.org/10.1124/dmd.118.082958