Zobrazeno 1 - 10
of 1 726
pro vyhledávání: '"Swanton, P."'
Autor:
M. Teresa Bertran, Robert Walmsley, Thomas Cummings, Iker Valle Aramburu, Donald J. Benton, Rocio Mora Molina, Jayalini Assalaarachchi, Maria Chasampalioti, Tessa Swanton, Dhira Joshi, Stefania Federico, Hanneke Okkenhaug, Lu Yu, David Oxley, Simon Walker, Venizelos Papayannopoulos, Hiroaki Suga, Maria A. Christophorou, Louise J. Walport
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Peptidylarginine deiminase IV (PADI4, PAD4) deregulation promotes the development of autoimmunity, cancer, atherosclerosis and age-related tissue fibrosis. PADI4 additionally mediates immune responses and cellular reprogramming, although the
Externí odkaz:
https://doaj.org/article/f39911ea87f547c599b7661118b8999a
Autor:
Coggan, Helena, Weeden, Clare E., Pearce, Philip, Dalwadi, Mohit P., Magness, Alastair, Swanton, Charles, Page, Karen M.
Mutations in the epidermal growth factor receptor (EGFR) are common in non-small cell lung cancer (NSCLC), particularly in never-smoker patients. However, these mutations are not always carcinogenic, and have recently been reported in histologically
Externí odkaz:
http://arxiv.org/abs/2303.11342
Autor:
Hugh O'Brien, Max Salm, Laura T Morton, Maciej Szukszto, Felix O'Farrell, Charlotte Boulton, Laurence King, Supreet Kaur Bola, Pablo D Becker, Andrew Craig, Morten Nielsen, Yardena Samuels, Charles Swanton, Marc R Mansour, Sine Reker Hadrup, Sergio A Quezada
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 11, p e1012511 (2024)
Neoantigen immunogenicity prediction is a highly challenging problem in the development of personalised medicines. Low reactivity rates in called neoantigens result in a difficult prediction scenario with limited training datasets. Here we describe I
Externí odkaz:
https://doaj.org/article/d0648697accf4d3db851dc1ee5b36eb3
Autor:
Michelle Dietzen, Haoran Zhai, Olivia Lucas, Oriol Pich, Christopher Barrington, Wei-Ting Lu, Sophia Ward, Yanping Guo, Robert E. Hynds, Simone Zaccaria, Charles Swanton, Nicholas McGranahan, Nnennaya Kanu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract During each cell cycle, the process of DNA replication timing is tightly regulated to ensure the accurate duplication of the genome. The extent and significance of alterations in this process during malignant transformation have not been ext
Externí odkaz:
https://doaj.org/article/75d9529c521a47218d12699e8e1533c7
Autor:
Sebastijan Hobor, Maise Al Bakir, Crispin T. Hiley, Marcin Skrzypski, Alexander M. Frankell, Bjorn Bakker, Thomas B. K. Watkins, Aleksandra Markovets, Jonathan R. Dry, Andrew P. Brown, Jasper van der Aart, Hilda van den Bos, Diana Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H. Rabinowitz, Laila Ait Hassou, Saskia Litière, D. Lucas Kerr, Lisa Tan, Gavin Kelly, David A. Moore, Matthew J. Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R. M. Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M. Blakely, Elza C. de Bruin, Floris Foijer, Karen H. Vousden, Trever G. Bivona, TRACERx consortium, Robert E. Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis of mixed intra-patient tumor responses remains unclear. Here
Externí odkaz:
https://doaj.org/article/a58c4b29e1d8491b8078212067633916
Autor:
Alastair Magness, Emma Colliver, Katey S. S. Enfield, Claudia Lee, Masako Shimato, Emer Daly, David A. Moore, Monica Sivakumar, Karishma Valand, Dina Levi, Crispin T. Hiley, Philip S. Hobson, Febe van Maldegem, James L. Reading, Sergio A. Quezada, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The growing scale and dimensionality of multiplexed imaging require reproducible and comprehensive yet user-friendly computational pipelines. TRACERx-PHLEX performs deep learning-based cell segmentation (deep-imcyto), automated cell-type ann
Externí odkaz:
https://doaj.org/article/f61b4b8bd2f54cbd9679706490019396
Autor:
Robert E. Hynds, Ariana Huebner, David R. Pearce, Mark S. Hill, Ayse U. Akarca, David A. Moore, Sophia Ward, Kate H. C. Gowers, Takahiro Karasaki, Maise Al Bakir, Gareth A. Wilson, Oriol Pich, Carlos Martínez-Ruiz, A. S. Md Mukarram Hossain, Simon P. Pearce, Monica Sivakumar, Assma Ben Aissa, Eva Grönroos, Deepak Chandrasekharan, Krishna K. Kolluri, Rebecca Towns, Kaiwen Wang, Daniel E. Cook, Leticia Bosshard-Carter, Cristina Naceur-Lombardelli, Andrew J. Rowan, Selvaraju Veeriah, Kevin Litchfield, Philip A. J. Crosbie, Caroline Dive, Sergio A. Quezada, Sam M. Janes, Mariam Jamal-Hanjani, Teresa Marafioti, TRACERx consortium, Nicholas McGranahan, Charles Swanton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Patient-derived xenograft (PDX) models are widely used in cancer research. To investigate the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX models from 22 patients enrolled in the TRACERx study. Multi-regio
Externí odkaz:
https://doaj.org/article/15a9cb6171ca46d4a07fbfbe6bf74b76
Autor:
Giovanni Giangreco, Antonio Rullan, Yutaka Naito, Dhruva Biswas, Yun-Hsin Liu, Steven Hooper, Pablo Nenclares, Shreerang Bhide, Maggie Chon U Cheang, Probir Chakravarty, Eishu Hirata, Charles Swanton, Alan Melcher, Kevin Harrington, Erik Sahai
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110635- (2024)
Summary: Interactions between cells in the tumor microenvironment (TME) shape cancer progression and patient prognosis. To gain insights into how the TME influences cancer outcomes, we derive gene expression signatures indicative of signaling between
Externí odkaz:
https://doaj.org/article/c33deebabf5c4f759f8aa0451259ec61
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Oxidative stress responses of Arabidopsis to reflected low red to far-red signals (R:FR ≈ 0.3) generated by neighboring weeds or an artificial source of FR light were compared with a weed-free control (R:FR ≈1.6). In the low R:FR treatments, indu
Externí odkaz:
https://doaj.org/article/b16134b6a59643109a75225e1b997e24
Autor:
Helena Coggan, Clare E. Weeden, Philip Pearce, Mohit P. Dalwadi, Alastair Magness, Charles Swanton, Karen M. Page
Publikováno v:
Royal Society Open Science, Vol 11, Iss 7 (2024)
Mutations in the epidermal growth factor receptor (EGFR) are common in non-small cell lung cancer (NSCLC), particularly in never-smoker patients. However, these mutations are not always carcinogenic, and have recently been reported in histologically
Externí odkaz:
https://doaj.org/article/66b04cbe687f41668f6288b2cb3af1b2