A Preliminary Report: The Hippocampus and Surrounding Temporal Cortex of Patients With Schizophrenia Have Impaired Blood-Brain Barrier

Autor: Goldwaser, Eric L., Swanson II, Randel L., Arroyo, Edgardo J., Venkataraman, Venkat, Kosciuk, Mary C., Nagele, Robert G., Hong, L. Elliot, Acharya, Nimish K.

Publikováno v: Frontiers in Human Neuroscience. 16

Though hippocampal volume reduction is a pathological hallmark of schizophrenia, the molecular pathway(s) responsible for this degeneration remains unknown. Recent reports have suggested the potential role of impaired blood-brain barrier (BBB) functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adbe14ff3ca12c2edbdc7793b9f1c92
https://doi.org/10.3389/fnhum.2022.836980

A Chronic Increase in Blood-Brain Barrier Permeability Facilitates Intraneuronal Deposition of Exogenous Bloodborne Amyloid-Beta1-42 Peptide in the Brain and Leads to Alzheimer's Disease-Relevant Cognitive Changes in a Mouse Model.

Autor: Acharya NK; Department of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.; Department of Cell Biology and Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.; Center for Neurotrauma, Neurodegeneration and Restoration, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Biomarker Discovery Center, New Jersey Institute for Successful Aging (NJISA), Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA.; Rowan-Virtua Graduate School of Biomedical Sciences, Stratford, NJ, USA.; Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Rowan University, Glassboro, NJ, USA., Grossman HC; Department of Psychology, Rutgers University, Piscataway, NJ, USA., Clifford PM; Department of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.; HNL Lab Medicine, Allentown, PA, USA., Levin EC; Department of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.; Department of Graduate Medical Education, Bayhealth Medical Center, Dover, DE, USA., Light KR; Department of Psychology, Barnard College of Columbia University, New York, NY, USA., Choi H; Rowan-Virtua Graduate School of Biomedical Sciences, Stratford, NJ, USA., Swanson Ii RL; Center for Neurotrauma, Neurodegeneration and Restoration, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Rehab Medicine Service, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Physical Medicine and Rehabilitation, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Kosciuk MC; Department of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA., Venkataraman V; Department of Cell Biology and Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.; Department of Academic and Student Affairs, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA., Libon DJ; Department of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.; Department of Psychology, Rowan University, Glassboro, NJ, USA., Matzel LD; Department of Psychology, Rutgers University, Piscataway, NJ, USA., Nagele RG; Department of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.; Biomarker Discovery Center, New Jersey Institute for Successful Aging (NJISA), Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA.; Rowan-Virtua Graduate School of Biomedical Sciences, Stratford, NJ, USA.; Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Rowan University, Glassboro, NJ, USA.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024; Vol. 98 (1), pp. 163-186.