Rational design of vitamin D3 analogues which selectively restore activity to a vitamin D receptor mutant associated with rickets

Autor: John T. Koh, Joel J. Bergh, Swann Sl, Mary C. Farach-Carson

Publikováno v: Organic letters. 4(22)

[formula: see text] Vitamin D3-resistant rickets (VDRR) is associated with mutations to the Vitamin D receptor (VDR) which effect ligand-dependent transactivation. Some VDRR associated mutants directly disrupt ligand binding. Using the reported VDR-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9cd80256ca86e4f9c27b7ccde5e6fe
https://pubmed.ncbi.nlm.nih.gov/12599478

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Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.

Autor: Dietrich JD; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Longenecker KL; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Wilson NS; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Goess C; AbbVie Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605, United States., Panchal SC; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Swann SL; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Petros AM; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Hobson AD; AbbVie Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605, United States., Ihle D; AbbVie Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605, United States., Song D; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Richardson P; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Comess KM; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Cox PB; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Dombrowski A; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Sarris K; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Donnelly-Roberts DL; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Duignan DB; AbbVie Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605, United States., Gomtsyan A; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Jung P; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Krueger AC; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Mathieu S; AbbVie Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605, United States., McClure A; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Stoll VS; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Wetter J; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Mankovich JA; AbbVie Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605, United States., Hajduk PJ; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Vasudevan A; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Stoffel RH; AbbVie Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605, United States., Sun C; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Jan 14; Vol. 64 (1), pp. 417-429. Date of Electronic Publication: 2020 Dec 30.

A unified, probabilistic framework for structure- and ligand-based virtual screening.

Autor: Swann SL; Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, United States., Brown SP, Muchmore SW, Patel H, Merta P, Locklear J, Hajduk PJ

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2011 Mar 10; Vol. 54 (5), pp. 1223-32. Date of Electronic Publication: 2011 Feb 10.