Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Swann Gaulis"'
Autor:
Leonor Schubert Santana, Alejandro Reyes, Sebastian Hoersch, Enrico Ferrero, Christian Kolter, Swann Gaulis, Sebastian Steinhauser
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2190-2199 (2024)
Spatiotemporal regulation of gene expression is controlled by transcription factor (TF) binding to regulatory elements, resulting in a plethora of cell types and cell states from the same genetic information. Due to the importance of regulatory eleme
Externí odkaz:
https://doaj.org/article/b389b0582e8748f19a3f095d7b02a90d
Autor:
Melusine Bleu, Swann Gaulis, Rui Lopes, Kathleen Sprouffske, Verena Apfel, Sjoerd Holwerda, Marco Pregnolato, Umut Yildiz, Valentina Cordoʹ, Antonella F. M. Dost, Judith Knehr, Walter Carbone, Felix Lohmann, Charles Y. Lin, James E. Bradner, Audrey Kauffmann, Luca Tordella, Guglielmo Roma, Giorgio G. Galli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activ
Externí odkaz:
https://doaj.org/article/a841cd70bc974e82bf6c4f6bbe42719f
Autor:
Sébastien Jeay, Swann Gaulis, Stéphane Ferretti, Hans Bitter, Moriko Ito, Thérèse Valat, Masato Murakami, Stephan Ruetz, Daniel A Guthy, Caroline Rynn, Michael R Jensen, Marion Wiesmann, Joerg Kallen, Pascal Furet, François Gessier, Philipp Holzer, Keiichi Masuya, Jens Würthner, Ensar Halilovic, Francesco Hofmann, William R Sellers, Diana Graus Porta
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/29da49791cad4fb8895cef0bf7f76fea
Autor:
Sébastien Jeay, Swann Gaulis, Stéphane Ferretti, Hans Bitter, Moriko Ito, Thérèse Valat, Masato Murakami, Stephan Ruetz, Daniel A Guthy, Caroline Rynn, Michael R Jensen, Marion Wiesmann, Joerg Kallen, Pascal Furet, François Gessier, Philipp Holzer, Keiichi Masuya, Jens Würthner, Ensar Halilovic, Francesco Hofmann, William R Sellers, Diana Graus Porta
Publikováno v:
eLife, Vol 4 (2015)
Biomarkers for patient selection are essential for the successful and rapid development of emerging targeted anti-cancer therapeutics. In this study, we report the discovery of a novel patient selection strategy for the p53–HDM2 inhibitor NVP-CGM09
Externí odkaz:
https://doaj.org/article/c47da66860c643148939459e36ed4a7e
Autor:
Beat Nyfeler, Dominic Hoepfner, Deborah Palestrant, Christina A Kirby, Lewis Whitehead, Robert Yu, Gejing Deng, Ruth E Caughlan, Angela L Woods, Adriana K Jones, S Whitney Barnes, John R Walker, Swann Gaulis, Ervan Hauy, Saskia M Brachmann, Philipp Krastel, Christian Studer, Ralph Riedl, David Estoppey, Thomas Aust, N Rao Movva, Zuncai Wang, Michael Salcius, Gregory A Michaud, Gregory McAllister, Leon O Murphy, John A Tallarico, Christopher J Wilson, Charles R Dean
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e42657 (2012)
Argyrins, produced by myxobacteria and actinomycetes, are cyclic octapeptides with antibacterial and antitumor activity. Here, we identify elongation factor G (EF-G) as the cellular target of argyrin B in bacteria, via resistant mutant selection and
Externí odkaz:
https://doaj.org/article/8cc21bffe9b742f29677cb5ec08eb108
Autor:
Sauveur-Michel Maira, Francesco Hofmann, William R. Sellers, Carlos Garcia-Echeverria, Christine Fritsch, Thomas Brümmendorf, Christopher Wilson, Sebastian Bergling, Dario Sterker, Daniel Alexander Guthy, Masato Murakami, Chrystèle Henry, Vincent Romanet, Juliane Vaxelaire, Fabian Stauffer, Marc Hattenberger, Laurent Laborde, Malika Kazic-Legueux, Marcel J.J. Blommers, Audrey Kauffmann, Swann Gaulis, Julia Kleylein-Sohn, Saskia M. Brachmann
PDF file, 300KB, A. Upon infection with viral particles obtained from the pBabe-puro-myr-Akt retroviral vectors, pools were selected upon addition of puromycin and maintained in culture for several weeks. Extracts from pools were generated for the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e85719f22ad670c32e0e20ca95848c4
https://doi.org/10.1158/1535-7163.22497505.v1
https://doi.org/10.1158/1535-7163.22497505.v1
Autor:
Sauveur-Michel Maira, Francesco Hofmann, William R. Sellers, Carlos Garcia-Echeverria, Christine Fritsch, Thomas Brümmendorf, Christopher Wilson, Sebastian Bergling, Dario Sterker, Daniel Alexander Guthy, Masato Murakami, Chrystèle Henry, Vincent Romanet, Juliane Vaxelaire, Fabian Stauffer, Marc Hattenberger, Laurent Laborde, Malika Kazic-Legueux, Marcel J.J. Blommers, Audrey Kauffmann, Swann Gaulis, Julia Kleylein-Sohn, Saskia M. Brachmann
The pan-phosphoinositide 3-kinase (PI3K) inhibitor BKM120 was found, at high concentrations, to cause cell death in various cellular systems, irrespective of their level of PI3K addiction. Transcriptional and biochemical profiling studies were used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9e949ba02432e441b240886f582f3e
https://doi.org/10.1158/1535-7163.c.6535633.v1
https://doi.org/10.1158/1535-7163.c.6535633.v1
Autor:
Sauveur-Michel Maira, Francesco Hofmann, William R. Sellers, Carlos Garcia-Echeverria, Christine Fritsch, Thomas Brümmendorf, Christopher Wilson, Sebastian Bergling, Dario Sterker, Daniel Alexander Guthy, Masato Murakami, Chrystèle Henry, Vincent Romanet, Juliane Vaxelaire, Fabian Stauffer, Marc Hattenberger, Laurent Laborde, Malika Kazic-Legueux, Marcel J.J. Blommers, Audrey Kauffmann, Swann Gaulis, Julia Kleylein-Sohn, Saskia M. Brachmann
PDF file, 53KB, A and B. 5x105 A2058 cells were seeded in 10 cm dishes and incubated for 24 h either with increasing amounts of BKM120 (A) or with 5 �M of either GDC-0941 (B, top panel) or BEZ235 (B, bottom panel). Cells were then fixed, prepared a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a8005a8fc2499aab45393ef7ce9197
https://doi.org/10.1158/1535-7163.22497502.v1
https://doi.org/10.1158/1535-7163.22497502.v1
Autor:
Sauveur-Michel Maira, Francesco Hofmann, William R. Sellers, Carlos Garcia-Echeverria, Christine Fritsch, Thomas Brümmendorf, Christopher Wilson, Sebastian Bergling, Dario Sterker, Daniel Alexander Guthy, Masato Murakami, Chrystèle Henry, Vincent Romanet, Juliane Vaxelaire, Fabian Stauffer, Marc Hattenberger, Laurent Laborde, Malika Kazic-Legueux, Marcel J.J. Blommers, Audrey Kauffmann, Swann Gaulis, Julia Kleylein-Sohn, Saskia M. Brachmann
PDF file, 107KB, A. 2.5x106 Rat1-myr-p110a (left) or U87MG cells were seeded in 10 cm dishes and exposed for 6h either to BKM120 (5 �M) or to the DMSO control. Cells were then lyzed and cell extracts were analyzed by Western-blot for PI3K pathway i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d66c84c9711e1f57c03039db66552f
https://doi.org/10.1158/1535-7163.22497490
https://doi.org/10.1158/1535-7163.22497490
Autor:
Sauveur-Michel Maira, Francesco Hofmann, William R. Sellers, Carlos Garcia-Echeverria, Christine Fritsch, Thomas Brümmendorf, Christopher Wilson, Sebastian Bergling, Dario Sterker, Daniel Alexander Guthy, Masato Murakami, Chrystèle Henry, Vincent Romanet, Juliane Vaxelaire, Fabian Stauffer, Marc Hattenberger, Laurent Laborde, Malika Kazic-Legueux, Marcel J.J. Blommers, Audrey Kauffmann, Swann Gaulis, Julia Kleylein-Sohn, Saskia M. Brachmann
PDF file, 113KB, A. Effects of Paclitaxel and Nocodazole on Tubulin polymerization. Tubulin was mixed with either Paclitaxel (10 �M), Nocodazole (10 �M) or the DMSO control in the presence of GTP. The polymerization of monomeric tubulin into micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d333cf1e56969fe429fae59107631d2
https://doi.org/10.1158/1535-7163.22497496.v1
https://doi.org/10.1158/1535-7163.22497496.v1