Mapping Differential Protein-Protein Interaction Networks using Affinity Purification Mass Spectrometry

Autor: Kaushal, Prashant, Ummadi, Manisha R., Jang, Gwendolyn M., Delgado, Yennifer, Makanani, Sara K., Blanc, Sophie F., Winters, Decan M., Xu, Jiewei, Polacco, Benjamin, Zhou, Yuan, Stevenson, Erica, Eckhardt, Manon, Zuliani-Alvarez, Lorena, Kaake, Robyn, Swaney, Danielle L., Krogan, Nevan, Bouhaddou, Mehdi

Proteins congregate into complexes to perform fundamental cellular functions. Phenotypic outcomes, in health and disease, are often mechanistically driven by the remodeling of protein complexes by protein coding mutations or cellular signaling change

Externí odkaz: http://arxiv.org/abs/2405.09699

A large topographic feature on the surface of the trans-Neptunian object (307261) 2002 MS$_4$ measured from stellar occultations

Autor: Rommel, F. L., Braga-Ribas, F., Ortiz, J. L., Sicardy, B., Santos-Sanz, P., Desmars, J., Camargo, J. I. B., Vieira-Martins, R., Assafin, M., Morgado, B. E., Boufleur, R. C., Benedetti-Rossi, G., Gomes-Júnior, A. R., Fernández-Valenzuela, E., Holler, B. J., Souami, D., Duffard, R., Margoti, G., Vara-Lubiano, M., Lecacheux, J., Plouvier, J. L., Morales, N., Maury, A., Fabrega, J., Ceravolo, P., Jehin, E., Albanese, D., Mariey, H., Cikota, S., Ruždjak, D., Cikota, A., Szakáts, R., Aissa, D. Baba, Gringahcene, Z., Kashuba, V., Koshkin, N., Zhukov, V., Fişek, S., Çakır, O., Özer, S., Schnabel, C., Schnabel, M., Signoret, F., Morrone, L., Santana-Ros, T., Pereira, C. L., Emilio, M., Burdanov, A. Y., de Wit, J., Barkaoui, K., Gillon, M., Leto, G., Frasca, A., Catanzaro, G., Sanchez, R. Zanmar, Tagliaferri, U., Di Sora, M., Isopi, G., Krugly, Y., Slyusarev, I., Chiorny, V., Mikuž, H., Bacci, P., Maestripieri, M., Grazia, M. D., de la Cueva, I., Yuste-Moreno, M., Ciabattari, F., Kozhukhov, O. M., Serra-Ricart, M., Alarcon, M. R., Licandro, J., Masi, G., Bacci, R., Bosch, J. M., Behem, R., Prost, J. -P., Renner, S., Conjat, M., Bachini, M., Succi, G., Stoian, L., Juravle, A., Carosati, D., Gowe, B., Carrillo, J., Zheleznyak, A. P., Montigiani, N., Foster, C. R., Mannucci, M., Ruocco, N., Cuevas, F., Di Marcantonio, P., Coretti, I., Iafrate, G., Baldini, V., Collins, M., Pál, A., Csák, B., Fernández-Garcia, E., Castro-Tirado, A. J., Hudin, L., Madiedo, J. M., Anghel, R. M., Calvo-Fernández, J. F., Valvasori, A., Guido, E., Gherase, R. M., Kamoun, S., Fafet, R., Sánchez-González, M., Curelaru, L., Vîntdevară, C. D., Danescu, C. A., Gout, J. -F., Schmitz, C. J., Sota, A., Belskaya, I., Rodríguez-Marco, M., Kilic, Y., Frappa, E., Klotz, A., Lavayssière, M., Oliveira, J. Marques, Popescu, M., Mammana, L. A., Fernández-Lajús, E., Schmidt, M., Hopp, U., Komžík, R., Pribulla, T., Tomko, D., Husárik, M., Erece, O., Eryilmaz, S., Buzzi, L., Gährken, B., Nardiello, D., Hornoch, K., Sonbas, E., Er, H., Burwitz, V., Sybilski, P. Waldemar, Bykowski, W., Müller, T. G., Ogloza, W., Gonçalves, R., Ferreira, J. F., Ferreira, M., Bento, M., Meister, S., Bagiran, M. N., Tekeş, M., Marciniak, A., Moravec, Z., Delinčák, P., Gianni, G., Casalnuovo, G. B., Boutet, M., Sanchez, J., Klemt, B., Wuensche, N., Burzynski, W., Borkowski, M., Serrau, M., Dangl, G., Klös, O., Weber, C., Urbaník, M., Rousselot, L., Kubánek, J., André, P., Colazo, C., Spagnotto, J., Sickafoose, A. A., Hueso, R., Sánchez-Lavega, A., Fisher, R. S., Rengstorf, A. W., Perelló, C., Dascalu, M., Altan, M., Gazeas, K., de Santana, T., Sfair, R., Winter, O. C., Kalkan, S., Canales-Moreno, O., Trigo-Rodríguez, J. M., Tsamis, V., Tigani, K., Sioulas, N., Lekkas, G., Bertesteanu, D. N., Dumitrescu, V., Wilberger, A. J., Barnes, J. W., Fieber-Beyer, S. K., Swaney, R. L., Fuentes, C., Mendez, R. A., Dumitru, B. D., Flynn, R. L., Wake, D. A.

Publikováno v: A&A 678, A167 (2023)

This work aims at constraining the size, shape, and geometric albedo of the dwarf planet candidate 2002 MS4 through the analysis of nine stellar occultation events. Using multichord detection, we also studied the object's topography by analyzing the

Externí odkaz: http://arxiv.org/abs/2308.08062

MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features

Autor: Charlotte D. Eaton, Lauro Avalos, S. John Liu, Zhenhong Chen, Naomi Zakimi, Tim Casey-Clyde, Paola Bisignano, Calixto-Hope G. Lucas, Erica Stevenson, Abrar Choudhury, Harish N. Vasudevan, Stephen T. Magill, Jacob S. Young, Nevan J. Krogan, Javier E. Villanueva-Meyer, Danielle L. Swaney, David R. Raleigh

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Meningiomas are associated with inactivation of NF2/Merlin, but approximately one-third of meningiomas with favorable clinical outcomes retain Merlin expression. Biochemical mechanisms underlying Merlin-intact meningioma growth are incomplet

Externí odkaz: https://doaj.org/article/09cad89a882942b286e00cb8af45c58a

Combined metagenomic- and culture-based approaches to investigate bacterial strain–level associations with medication-controlled mild-moderate atopic dermatitis

Autor: Nicole M. Lane Starr, PhD, Numan Al-Rayyan, PhD, Jennifer M. Smith, BA, Shelby Sandstrom, BSc, Mary Hannah Swaney, PhD, Rauf Salamzade, BSc, Olivia Steidl, MPH, Lindsay R. Kalan, PhD, Anne Marie Singh, MD

Publikováno v: Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 3, Pp 100259- (2024)

Background: The skin microbiome is disrupted in atopic dermatitis (AD). Existing research focuses on moderate to severe, unmedicated disease. Objective: We sought to investigate metagenomic- and culture-based bacterial strain–level differences in m

Externí odkaz: https://doaj.org/article/d3eb5303ee4a4c1ea497f32c51891c47

Epigenetic reprogramming shapes the cellular landscape of schwannoma

Autor: S. John Liu, Tim Casey-Clyde, Nam Woo Cho, Jason Swinderman, Melike Pekmezci, Mark C. Dougherty, Kyla Foster, William C. Chen, Javier E. Villanueva-Meyer, Danielle L. Swaney, Harish N. Vasudevan, Abrar Choudhury, Joanna Pak, Jonathan D. Breshears, Ursula E. Lang, Charlotte D. Eaton, Kamir J. Hiam-Galvez, Erica Stevenson, Kuei-Ho Chen, Brian V. Lien, David Wu, Steve E. Braunstein, Penny K. Sneed, Stephen T. Magill, Daniel Lim, Michael W. McDermott, Mitchel S. Berger, Arie Perry, Nevan J. Krogan, Marlan R. Hansen, Matthew H. Spitzer, Luke Gilbert, Philip V. Theodosopoulos, David R. Raleigh

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Mechanisms specifying cancer cell states and response to therapy are incompletely understood. Here we show epigenetic reprogramming shapes the cellular landscape of schwannomas, the most common tumors of the peripheral nervous system. We fin

Externí odkaz: https://doaj.org/article/6c3cb10a1a664ce0a55f363c96e7591d