Výsledky vyhledávání - "Swanand Kulkarni"

Recent Advancements in the Discovery of MDM2/MDM2-p53 Interaction Inhibitors for the Treatment of Cancer

Autor: Suresh Thareja, Neha Bhatia, Rakesh Khator, Swanand Kulkarni, Yogesh Singh, Pradeep Kumar

Publikováno v: Current Medicinal Chemistry. 30:3668-3701

Abstract: Discovery of MDM2 and MDM2-p53 interaction inhibitors changed the direction of anticancer research as it is involved in about 50% of cancer cases globally. Not only the inhibition of MDM2 but also its interaction with p53 proved to be an ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::716fcfa20c062ff5c04fd48d2eea74c4
https://doi.org/10.2174/0929867330666221114103924

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Tensile Behaviour of Starch Based Naturally Woven Coconut Leaf Sheath Reinforced Biodegradable Composite

Autor: Pratik Kulkarni, Swanand Kulkarni

Publikováno v: International Journal for Research in Applied Science and Engineering Technology. 11:193-196

Hazardous effects of plastic on human health and environment have accelerated the rate of research in the field of natural fiber composites. Coconut sheath is having potential to be used as a reinforcement to produce biodegradable composite. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfca3ed4dd805aa9b37608c9c394670d
https://doi.org/10.22214/ijraset.2023.49388

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Molecular docking, 3D-QSAR and simulation studies for identifying pharmacophoric features of indole derivatives as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5) inhibitors

Autor: Swanand Kulkarni, Yogesh Singh, Avadh Biharee, Neha Bhatia, Vikramdeep Monga, Suresh Thareja

Publikováno v: Journal of Biomolecular Structure and Dynamics. :1-18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0d14805cdc014e33a112ea352bf8c73
https://doi.org/10.1080/07391102.2023.2175265

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Flavonoids as promising anticancer agents: an in silico investigation of ADMET, binding affinity by molecular docking and molecular dynamics simulations

Autor: Avadh Biharee, Arpita Yadav, Kailash Jangid, Yogesh Singh, Swanand Kulkarni, Devesh M. Sawant, Pradeep Kumar, Suresh Thareja, Akhlesh Kumar Jain

Publikováno v: Journal of Biomolecular Structure and Dynamics. :1-12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0ef4453e0552941823eeccdb8ed9699
https://doi.org/10.1080/07391102.2022.2126397

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Recent Developments in Oxazole Derivatives as Anticancer Agents: Review on Synthetic Strategies, Mechanism of Action and SAR Studies

Autor: Kamalpreet Kaur, Swanand Kulkarni, Vikas Jaitak

Publikováno v: Anti-Cancer Agents in Medicinal Chemistry. 22:1859-1882

Background: Cancer is the world’s third deadliest disease. Despite the availability of numerous treatments, researchers are focusing on the development of new drugs with no resistance and toxicity issues. Many newly synthesized drugs fail to reach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4610d46084a0377eb13ca5069b39b7fd
https://doi.org/10.2174/1871520621666210915095421

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Phosphate Prodrugs: An Approach to Improve the Bioavailability of Clinically Approved Drugs

Autor: Suresh Thareja, Tanmoy Tantra, Yogesh Singh, Rohan Patekar, Swanand Kulkarni, Pradeep Kumar

Publikováno v: Current Medicinal Chemistry. 30

Abstract: The phosphate prodrug approach has emerged as a viable option for increasing the bioavailability of a drug candidate with low hydrophilicity and poor cell membrane permeability. When a phosphoric acid moiety is attached to the parent drug,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdabe4ab76e069e080683d4bfbee1c10
https://doi.org/10.2174/0929867330666230209094738

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Medicinal chemistry aspects and synthetic strategies of coumarin as aromatase inhibitors: an overview

Autor: Pooja Ratre, Swanand Kulkarni, Sweety Das, Chengyuan Liang, Pradyumna Kumar Mishra, Suresh Thareja

Publikováno v: Medical oncology (Northwood, London, England). 40(1)

Coumarin is a bicyclic oxygen bearing heterocyclic scaffold formed by fusion of benzene with the pyrone ring. Because of its unique physicochemical characteristics and the ease with which it may be transformed into a wide range of functionalized coum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372cdf93f7524206a6b038eb0658e205
https://pubmed.ncbi.nlm.nih.gov/36471176

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Flavonoids as promising anticancer agents: an

Autor: Avadh, Biharee, Arpita, Yadav, Kailash, Jangid, Yogesh, Singh, Swanand, Kulkarni, Devesh M, Sawant, Pradeep, Kumar, Suresh, Thareja, Akhlesh Kumar, Jain

Publikováno v: Journal of biomolecular structuredynamics.

Cancer is one of the most concerning diseases to humankind. Various treatment strategies are being employed for its treatment, out of which use of natural products is an essential one. Flavonoids have proven to be promising anticancer targets since d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f50340b77be5848b8c2f5dd3685542d4
https://pubmed.ncbi.nlm.nih.gov/36165610

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