Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Swan Hwang"'
Autor:
Yuno Lee, Songmi Kim, Jun Young Kim, Mahreen Arooj, Siu Kim, Swan Hwang, Byeong-Woo Kim, Ki Hun Park, Keun Woo Lee
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85827 (2014)
Stilbene urea derivatives as a novel and competitive class of non-glycosidic α-glucosidase inhibitors are effective for the treatment of type II diabetes and obesity. The main purposes of our molecular modeling study are to explore the most suitable
Externí odkaz:
https://doaj.org/article/d3ce32c651c1477a9d8cc4227adf0de6
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68271 (2013)
The sonic hedgehog (Shh) signaling pathway is necessary for a variety of development and differentiation during embryogenesis as well as maintenance and renascence of diverse adult tissues. However, an abnormal activation of the signaling pathway is
Externí odkaz:
https://doaj.org/article/8547b8ce51d444719f5511f4c60135cb
Autor:
Yuno Lee, Songmi Kim, Prettina Lazar, Jeong Chan Moon, Swan Hwang, Sundarapandian Thangapandian, Youngsik Shon, Kyun Oh Lee, Sang Yeol Lee, Keun Woo Lee
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46279 (2012)
2-Cys peroxiredoxins (Prxs) play important roles in the protection of chloroplast proteins from oxidative damage. Arabidopsis NADPH-dependent thioredoxin reductase isotype C (AtNTRC) was identified as efficient electron donor for chloroplastic 2-Cys
Externí odkaz:
https://doaj.org/article/14eb5bd036da421f9a917fad63426292
Autor:
Swan Hwang, Mahreen Arooj, Keun W. Lee, Jong K. Park, Sundarapandian Thangapandian, Shalini John
Publikováno v:
Chemical Biology & Drug Design. 80:862-875
To provide a new idea for drug design, a computational investigation is performed on chymase and its novel 1,4-diazepane-2,5-diones inhibitors that explores the crucial molecular features contributing to binding specificity. Molecular docking studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2610ae07cae84a5b8bdeae44457635c0
https://doi.org/10.1111/cbdd.12006
https://doi.org/10.1111/cbdd.12006
Autor:
Keun Woo Lee, Sundarapandian Thangapandian, C. Meganathan, Swan Hwang, Sugunadevi Sakkiah, Venkatesh Arulalapperumal, Yuno Lee
Publikováno v:
Bulletin of the Korean Chemical Society. 33:1707-1714
Grb2 is an adapter protein involved in the signal transduction and cell communication. The Grb2 is responsible for initiation of kinase signaling by Ras activation which leads to the modification in transcription. Ligand based pharmacophore approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb3315ea211c0728a968dc2d16f19d80
https://doi.org/10.5012/bkcs.2012.33.5.1707
https://doi.org/10.5012/bkcs.2012.33.5.1707
Autor:
Mahreen Arooj, Shalini John, Keun Woo Lee, Swan Hwang, Sundarapandian Thangapandian, Jong Keun Park
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 12; Issue 12; Pages: 9236-9264
International Journal of Molecular Sciences, Vol 12, Iss 12, Pp 9236-9264 (2011)
International Journal of Molecular Sciences; Volume 12; Issue 12; Pages: 9236-9264
International Journal of Molecular Sciences, Vol 12, Iss 12, Pp 9236-9264 (2011)
Human chymase is a very important target for the treatment of cardiovascular diseases. Using a series of theoretical methods like pharmacophore modeling, database screening, molecular docking and Density Functional Theory (DFT) calculations, an inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51da6583225b1f270047741143dd6069
http://europepmc.org/articles/PMC3257128
http://europepmc.org/articles/PMC3257128
Autor:
Jung-Keun Suh, Songmi Kim, Swan Hwang, Yuno Lee, Minky Son, Chanin Park, Keun Woo Lee, Young-sik Sohn, Ayoung Baek, Hyong-Ha Kim
Publikováno v:
Bulletin of the Korean Chemical Society. 32:201-207
Peroxisome proliferator-activated receptors (PPARs) are members of nuclear receptors and their activation induces regulation of fatty acid storage and glucose metabolism. Therefore, the PPARγ is a major target for the treatment of type 2 diabetes me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d896c02e8839e81a283962d9cf31ba3
https://doi.org/10.5012/bkcs.2011.32.1.201
https://doi.org/10.5012/bkcs.2011.32.1.201
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 29(1)
Cellular Src (c-Src) kinases play a critical role in cell adhesion, proliferation, angiogenesis and cancer. Ligand-based pharmacophore models, used to identify the critical chemical features of c-Src inhibitors, were generated and validated by traini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6693c6ba097b2b6f291c7a3f2e40c9f
https://pubmed.ncbi.nlm.nih.gov/23432516
https://pubmed.ncbi.nlm.nih.gov/23432516
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68271 (2013)
PLOS ONE(8): 7
PLoS ONE
PLOS ONE(8): 7
PLoS ONE
The sonic hedgehog (Shh) signaling pathway is necessary for a variety of development and differentiation during embryogenesis as well as maintenance and renascence of diverse adult tissues. However, an abnormal activation of the signaling pathway is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119253ecf29c6724841b49122763da04
http://europepmc.org/articles/PMC3729836?pdf=render
http://europepmc.org/articles/PMC3729836?pdf=render
Autor:
Mahreen, Arooj, Sundarapandian, Thangapandian, Shalini, John, Swan, Hwang, Jong K, Park, Keun W, Lee
Publikováno v:
Chemical biologydrug design. 80(6)
To provide a new idea for drug design, a computational investigation is performed on chymase and its novel 1,4-diazepane-2,5-diones inhibitors that explores the crucial molecular features contributing to binding specificity. Molecular docking studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5920c34775ba4a6028628de8c668ec77
https://pubmed.ncbi.nlm.nih.gov/22834787
https://pubmed.ncbi.nlm.nih.gov/22834787