Safety, tolerability, pharmacokinetics and pharmacodynamics of the oral cyclin-dependent kinase inhibitor AZD5438 when administered at intermittent and continuous dosing schedules in patients with advanced solid tumours

Autor: Boss, D.S., Schwartz, G.K., Middleton, M.R., Amakye, D.D., Swaisland, H., Midgley, R.S., Ranson, M., Danson, S., Calvert, H., Plummer, R., Morris, C., Carvajal, R.D., Chirieac, L.R., Schellens, J.H.M. ^*, Shapiro, G.I.

Publikováno v: In Annals of Oncology April 2010 21(4):884-894

A first-in-human Phase I dose-escalation trial of the novel therapeutic peptide, ALM201, demonstrates a favourable safety profile in unselected patients with ovarian cancer and other advanced solid tumours.

Autor: El Helali A; Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.; University of Hong Kong, 21 Sassoon Road, Pok Fu Lam, Hong Kong., Plummer R; Newcastle University Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Jayson GC; Institute of Cancer Sciences and Christie Hospital, University of Manchester, Manchester, UK., Coyle VM; Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Drew Y; Newcastle University Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Mescallado N; Institute of Cancer Sciences and Christie Hospital, University of Manchester, Manchester, UK., Harris N; Newcastle University Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Clamp AR; Institute of Cancer Sciences and Christie Hospital, University of Manchester, Manchester, UK., McCann J; Northern Ireland Cancer Research Consumers' Forum, Belfast, UK., Swaisland H; Therakin Consulting Ltd., Sandbach, UK., Kennedy RD; Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.; Almac Diagnostic Services, Craigavon, UK., Cranston AN; Almac Discovery Ltd., Belfast, UK. Aaron.Cranston@almacgroup.com., Wilson RH; Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK. Richard.H.Wilson@glasgow.ac.uk.; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK. Richard.H.Wilson@glasgow.ac.uk.

Publikováno v: British journal of cancer [Br J Cancer] 2022 Jul; Vol. 127 (1), pp. 92-101. Date of Electronic Publication: 2022 May 14.

Internal Overview of Prostatic Cancer Cases and Quality of BRCA1 and BRCA2 NGS Data from the FFPE Tissue.

Autor: Antolini, Enrica¹ (AUTHOR) enricaa.58@gmail.com, Filosa, Alessandra^1,2 (AUTHOR) alessandra.filosa@ospedaliriuniti.marche.it, Santoni, Matteo³ (AUTHOR) matteo.santoni@sanita.marche.it, Antaldi, Elena² (AUTHOR) elisa.bartoli@ospedaliriuniti.mache.it, Bartoli, Elisa² (AUTHOR) lidia.sierchio@ospedaliriuniti.marche.it, Sierchio, Lidia² (AUTHOR) alessandra.mandolesi@ospedaliriuniti.marche.it, Giantomassi, Federica¹ (AUTHOR) g.goteri@univpm.it, Mandolesi, Alessandra² (AUTHOR), Goteri, Gaia^1,2 (AUTHOR)

Publikováno v: Diagnostics (2075-4418). Sep2024, Vol. 14 Issue 18, p2067. 9p.

The Pivotal Role of Preclinical Animal Models in Anti-Cancer Drug Discovery and Personalized Cancer Therapy Strategies.

Autor: Guo, Haochuan¹ (AUTHOR) 231212007@njnu.edu.cn, Xu, Xinru¹ (AUTHOR) 211202068@njnu.edu.cn, Zhang, Jiaxi¹ (AUTHOR) 231202046@njnu.edu.cn, Du, Yajing¹ (AUTHOR) 221202100@njnu.edu.cn, Yang, Xinbing¹ (AUTHOR) 221202124@njnu.edu.cn, He, Zhiheng² (AUTHOR) 1023173006@njupt.edu.cn, Zhao, Linjie² (AUTHOR) 1223014120@njupt.edu.cn, Liang, Tingming¹ (AUTHOR) tmliang@njnu.edu.cn, Guo, Li² (AUTHOR) tmliang@njnu.edu.cn

Publikováno v: Pharmaceuticals (14248247). Aug2024, Vol. 17 Issue 8, p1048. 30p.

PTEN Depletion Increases Radiosensitivity in Response to Ataxia Telangiectasia-Related-3 (ATR) Inhibition in Non-Small Cell Lung Cancer (NSCLC).

Autor: Dunne, Victoria L.¹ (AUTHOR) m.ghita@qub.ac.uk, Ghita-Pettigrew, Mihaela¹ (AUTHOR) kelly.redmond@qub.ac.uk, Redmond, Kelly M.¹ (AUTHOR) d.small@qub.ac.uk, Small, Donna M.¹ (AUTHOR) k.prise@qub.ac.uk, Weldon, Sinéad² (AUTHOR) s.weldon@qub.ac.uk, Taggart, Clifford C.² (AUTHOR) c.taggart@qub.ac.uk, Prise, Kevin M.¹ (AUTHOR) k.butterworth@qub.ac.uk, Hanna, Gerard G.³ (AUTHOR) g.hanna@qub.ac.uk, Butterworth, Karl T.¹ (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7817. 12p.