Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Swain Michael Lingard"'
Autor:
Michael B. Gravestock, Alexandra McGregor, Michael Dennis, R. Geoffrey Wilson, Lisa Woods, Alan Wookey, Michael John Betts, Glenn Hatter, Swain Michael Lingard, David G. Acton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4179-4186
Exploration of the structure-activity relationships of the traditional C-5 acetamidomethyl side chain of the oxazolidonone antibacterials has yielded new, potent series of compounds of which the first examples, the O-linked iosoxazoles are described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c874c281dd90c9f417e49a14b91e7749
https://doi.org/10.1016/j.bmcl.2003.07.033
https://doi.org/10.1016/j.bmcl.2003.07.033
Autor:
Barry R. Hayter, Julie A. Tucker, Leonie Campbell, Peter Ballard, Alison M. Griffen, Swain Michael Lingard, Jon Curwen, Martine J. Mellor, William McCoull, Richard W. A. Luke, Cliff Jones, Lorraine A. Hassall, David Buttar, Steve Emery
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(23)
The SAR and improvement in potency against Tie2 of novel thienopyrimidine and thiazolopyrimidine kinase inhibitors are reported. The crystal structure of one of these compounds bound to the Tie-2 kinase domain is consistent with the SAR. These compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7590d169e86ec829a3a3c09591cae8b3
https://pubmed.ncbi.nlm.nih.gov/19854647
https://pubmed.ncbi.nlm.nih.gov/19854647
Autor:
Kin Yip Tam, David Alan Rudge, Julie A. Tucker, Louise Moss, Barker Andrew John, Clifford David Jones, Peter B. Simpson, Alexandra McGregor, David M. Andrews, Michael A. Walker, Kevin Blades, Catherine Geh, Swain Michael Lingard, S J East, Keith M. Johnson, Heather M. McFarland, Mark A. Graham, Sarah A. Loddick, Paula Daunt
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(24)
The development of a novel series of imidazole pyrimidine amides as cyclin-dependent kinase (CDK) inhibitors is described. Optimisation of inhibitory potency against multiple CDK's (1, 2 and 9) resulted in imidazole pyrimidine amides with potent in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80517057acbe8649c1000fea635f799
https://pubmed.ncbi.nlm.nih.gov/18996007
https://pubmed.ncbi.nlm.nih.gov/18996007