Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Swagat Sharma"'
Publikováno v:
Current Opinion in Nephrology & Hypertension.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d52e00f24304fdda0fe8a54eecdc812
https://doi.org/10.1097/mnh.0000000000000897
https://doi.org/10.1097/mnh.0000000000000897
Autor:
Swagat Sharma, Juan L. Pablo, Kirsten T. Tolentino, Wacey Gallegos, Jennifer Hinman, Madison Beninato, MacKenzie Asche, Anna Greka, Corey R. Hopkins
Publikováno v:
ChemMedChem. 17
The transient receptor potential cation channel 5 (TRPC5) plays an important role in numerous cellular processes. Due to this, it has gained considerable attention over the past few years as a potential therapeutic target. Recently, TRPC5 has been sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c442e663775e6d270649c77808d171
https://doi.org/10.1002/cmdc.202200151
https://doi.org/10.1002/cmdc.202200151
Autor:
Swagat Sharma, Qi Peng, Anish K. Vadukoot, Christopher D. Aretz, Aaron A. Jensen, Alexander I. Wallick, Xinzhong Dong, Corey R. Hopkins
Publikováno v:
ACS Med Chem Lett
[Image: see text] The present study describes our continued efforts in the discovery and characterization of a series of 2-sulfonamidebenzamides as allosteric modulators of MrgX1. MrgX1 has been shown to be an attractive target as a nonopioid recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41db227b3095c3d83563ef62827730c
https://pubmed.ncbi.nlm.nih.gov/35586421
https://pubmed.ncbi.nlm.nih.gov/35586421
Autor:
Cortney E. Heim, Nagsen Gautam, Amy Aldrich, Sushil Kumar, Swagat Sharma, Anish K. Vadukoot, Yazen Alnouti, Christopher D. Aretz, Corey R. Hopkins, Tammy Kielian
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein we report the synthesis, SAR, and biological evaluation of a series of 1H-pyrrolo[2,3-b]pyridine-2-carboxamide derivatives as selective and potent PDE4B inhibitors. Compound 11h is a PDE4B preferring inhibitor and exhibited a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e282c52fb693d94bf235e60cf8e8ca31
https://doi.org/10.1021/acsmedchemlett.9b00369
https://doi.org/10.1021/acsmedchemlett.9b00369
Autor:
Corey R. Hopkins, Xinzhong Dong, Swagat Sharma, Qi Peng, Alexander Wallick, Christopher D Aretz, Anish K. Vadukoot, Aaron Jensen
The present study describes our continued efforts in the discovery and characterization of a series of 2-sulfonamidebenzamides as allosteric modulators of MrgX1. MrgX1 has been shown to be an attractive target as a non-opioid receptor for the potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7660425de7c53565282262c8d207f26e
https://doi.org/10.33774/chemrxiv-2021-7cq5k
https://doi.org/10.33774/chemrxiv-2021-7cq5k
Autor:
Christopher D. Aretz, Yazen Alnouti, Lauren Lesiak, C. David Weaver, Yashpal S. Chhonker, Nikilesh V. Dhuria, Sushil Kumar, Yu Du, Nagsen Gautam, Swagat Sharma, Corey R. Hopkins
Publikováno v:
RSC Med Chem
The present study describes the discovery and characterization of a series of N-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1H-pyrazol-5-yl)acetamide ethers as G protein-gated inwardly-rectifying potassium (GIRK) channel activators. From our pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2820c33e200f746c3cd7ae11f0a6780c
https://europepmc.org/articles/PMC8372201/
https://europepmc.org/articles/PMC8372201/
Autor:
Corey R. Hopkins, Swagat Sharma
Publikováno v:
Journal of Medicinal Chemistry. 62:7589-7602
Transient receptor potential canonical (TRPC) channels are highly homologous, nonselective cation channels that form many homo- and heterotetrameric channels. These channels are highly abundant in the brain and kidney and have been implicated in nume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c31a09f3d5a7ecfcc8734ba5eab4fa37
https://doi.org/10.1021/acs.jmedchem.8b01954
https://doi.org/10.1021/acs.jmedchem.8b01954
Autor:
Yazen Alnouti, Corey R. Hopkins, Kristopher K. Abney, Nagsen Gautam, Krystian A. Kozek, Sushil Kumar, Swagat Sharma, C. David Weaver
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:791-796
The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30a7ee1bbe244a19f91ad2ef281eb8e
https://doi.org/10.1016/j.bmcl.2019.01.027
https://doi.org/10.1016/j.bmcl.2019.01.027
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:155-159
The transient receptor potential cation channel 5 (TRPC5) has been previously shown to affect podocyte survival in the kidney. As such, inhibitors of TRPC5 are interesting candidates for the treatment of chronic kidney disease (CKD). Herein, we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1b949de0871d165eeb38ad10602aaf
https://doi.org/10.1016/j.bmcl.2018.12.007
https://doi.org/10.1016/j.bmcl.2018.12.007
Autor:
Punita Dhawan, Sandeep Rana, Balawant Kumar, Swagat Sharma, Amarnath Natarajan, Saiprasad Gowrikumar, Corey R. Hopkins, David Oupicky, Mark Primeaux, Amar B. Singh, Rizwan Ahmad
Publikováno v:
Cancers
Volume 13
Issue 9
Cancers, Vol 13, Iss 2168, p 2168 (2021)
Volume 13
Issue 9
Cancers, Vol 13, Iss 2168, p 2168 (2021)
Background: Despite recent advances in therapies, resistance to chemotherapy remains a critical problem in the clinical management of colorectal cancer (CRC). Cancer stem cells (CSCs) play a central role in therapy resistance. Thus, elimination of CS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610467929938079310ce3f62748b2afb