Fitness landscape of a dynamic RNA structure

Autor: Soo, VWC, Swadling, JB, Faure, AJ, Warnecke, T

RNA structures are dynamic. As a consequence, mutational effects can be hard to rationalize with reference to a single static native structure. We reasoned that deep mutational scanning experiments, which couple molecular function to fitness, should

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http://hdl.handle.net/10044/1/93526

Fitness landscape of a dynamic RNA structure.

Autor: Soo VWC; Medical Research Council London Institute of Medical Sciences, London, United Kingdom.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom., Swadling JB; Medical Research Council London Institute of Medical Sciences, London, United Kingdom.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom., Faure AJ; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Warnecke T; Medical Research Council London Institute of Medical Sciences, London, United Kingdom.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom.

Publikováno v: PLoS genetics [PLoS Genet] 2021 Feb 01; Vol. 17 (2), pp. e1009353. Date of Electronic Publication: 2021 Feb 01 (Print Publication: 2021).

An intestinal zinc sensor regulates food intake and developmental growth.

Autor: Redhai S; MRC London Institute of Medical Sciences, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Pilgrim C; MRC London Institute of Medical Sciences, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Gaspar P; MRC London Institute of Medical Sciences, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Giesen LV; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Lopes T; MRC London Institute of Medical Sciences, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Riabinina O; MRC London Institute of Medical Sciences, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; Department of Biosciences, Durham University, Durham, UK., Grenier T; Institut de Génomique Fonctionnelle de Lyon (IGFL), Université de Lyon, ENS de Lyon, CNRS UMR 5242, Lyon, France., Milona A; MRC London Institute of Medical Sciences, London, UK., Chanana B; MRC London Institute of Medical Sciences, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Swadling JB; MRC London Institute of Medical Sciences, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Wang YF; MRC London Institute of Medical Sciences, London, UK., Dahalan F; Department of Life Sciences, Imperial College London, London, UK.; Malaria Programme, Wellcome Sanger Institute, Cambridge, UK., Yuan M; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Wilsch-Brauninger M; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Lin WH; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Dennison N; Department of Life Sciences, Imperial College London, London, UK., Capriotti P; Department of Life Sciences, Imperial College London, London, UK., Lawniczak MKN; Malaria Programme, Wellcome Sanger Institute, Cambridge, UK., Baines RA; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Warnecke T; MRC London Institute of Medical Sciences, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Windbichler N; Department of Life Sciences, Imperial College London, London, UK., Leulier F; Institut de Génomique Fonctionnelle de Lyon (IGFL), Université de Lyon, ENS de Lyon, CNRS UMR 5242, Lyon, France., Bellono NW; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Miguel-Aliaga I; MRC London Institute of Medical Sciences, London, UK. i.miguel-aliaga@imperial.ac.uk.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. i.miguel-aliaga@imperial.ac.uk.

Publikováno v: Nature [Nature] 2020 Apr; Vol. 580 (7802), pp. 263-268. Date of Electronic Publication: 2020 Mar 18.

Origins of biological function in DNA and RNA hairpin loop motifs from replica exchange molecular dynamics simulation.

Autor: Swadling JB; School of Life Science and Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, M6-13, Meguro, Tokyo 152-8550, Japan. akitao@bio.titech.ac.jp., Ishii K, Tahara T, Kitao A

Publikováno v: Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2018 Jan 31; Vol. 20 (5), pp. 2990-3001.

Influence of surface chemistry and charge on mineral-RNA interactions.

Autor: Swadling JB; The Centre for Computational Science, Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, United Kingdom., Suter JL, Greenwell HC, Coveney PV

Publikováno v: Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2013 Feb 05; Vol. 29 (5), pp. 1573-83. Date of Electronic Publication: 2013 Jan 24.