Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Svitlana Shpyleva"'
Autor:
Dan Li, Leihong Wu, Mingfeng Zhang, Svitlana Shpyleva, Ying-Chi Lin, Ho-Yin Huang, Ting Li, Joshua Xu
Publikováno v:
Frontiers in Drug Safety and Regulation, Vol 4 (2024)
Pharmacovigilance plays a crucial role in ensuring the safety of pharmaceutical products. It involves the systematic monitoring of adverse events and the detection of potential safety concerns related to drugs. Manual literature screening for pharmac
Externí odkaz:
https://doaj.org/article/4fb1097fde0a401ebc5def1a72d69c78
Autor:
Svitlana Shpyleva, Samuil Ivanovsky, Aline de Conti, Stepan Melnyk, Volodymyr Tryndyak, Frederick A Beland, S Jill James, Igor P Pogribny
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113712 (2014)
The molecular pathogenesis of autism is complex and involves numerous genomic, epigenomic, proteomic, metabolic, and physiological alterations. Elucidating and understanding the molecular processes underlying the pathogenesis of autism is critical fo
Externí odkaz:
https://doaj.org/article/116c99930f954bb0a757f79588f11f4e
Autor:
Leihong, Wu, Si, Chen, Lei, Guo, Svitlana, Shpyleva, Kelly, Harris, Tariq, Fahmi, Timothy, Flanigan, Weida, Tong, Joshua, Xu, Zhen, Ren
Publikováno v:
Regulatory Toxicology and Pharmacology. 137:105287
In the field of regulatory science, reviewing literature is an essential and important step, which most of the time is conducted by manually reading hundreds of articles. Although this process is highly time-consuming and labor-intensive, most output
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da130d31e51b20a8570abb748478aae1
https://doi.org/10.1016/j.yrtph.2022.105287
https://doi.org/10.1016/j.yrtph.2022.105287
Autor:
Aline de Conti, Igor P. Pogribny, Kostiantyn Dreval, Volodymyr Tryndyak, Thilak K. Mudalige, Iryna Kindrat, Svitlana Shpyleva, Tao Chen, Frederick A. Beland, Anna M. Erstenyuk
Publikováno v:
Toxicology Letters. 281:65-73
The liver, a central detoxification organ and main regulator of systemic iron homeostasis, is prone to damage by xenobiotics. In the present study, we investigated the effect of the hepatotoxicant and hepatocarcinogen methapyrilene hydrochloride on i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1ba699d9af413a72bb81a1aee5db27
https://doi.org/10.1016/j.toxlet.2017.09.011
https://doi.org/10.1016/j.toxlet.2017.09.011
Autor:
April K. Marrone, Svitlana Shpyleva, Grace A. Chappell, Volodymyr Tryndyak, Frederick A. Beland, Masato Tsuchiya, Ivan Rusyn, Takeki Uehara, Igor P. Pogribny
Publikováno v:
Molecular Carcinogenesis. 55:808-817
Hepatocellular carcinoma (HCC) is one of the most prevalent human cancers, with a rising incidence worldwide. The molecular mechanisms associated with the development of HCC are complex and include multiple interconnected molecular alterations with m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::861d73ab03df97113e32e8a3c7096d04
https://doi.org/10.1002/mc.22323
https://doi.org/10.1002/mc.22323
Autor:
Svitlana Shpyleva, Igor P. Pogribny, David Sidransky, Olga Kovalchuk, Bryan Kolb, Amanda Katz, Yaroslav Ilnytskyy, Rocio Rodriguez-Juarez, Stepan Melnyk, Anna Kovalchuk
Publikováno v:
Aging (Albany NY)
Cancer chemotherapy causes numerous persistent central nervous system complications. This condition is known as chemo brain. Cognitive impairments occur even before treatment, and hence are referred to as cancer associated cognitive changes, or tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b43eac91a2c18a44f68fad1179ce6c
https://pubmed.ncbi.nlm.nih.gov/28758896
https://pubmed.ncbi.nlm.nih.gov/28758896
Autor:
Svitlana, Shpyleva, Kostiantyn, Dreval, Aline, de Conti, Iryna, Kindrat, Stepan, Melnyk, Jian, Yan, Tao, Chen, Frederick A, Beland, Igor P, Pogribny
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 156(1)
Continuous lifetime exposure to certain natural and man-made chemicals is a major cause of cancers in humans; therefore, evaluating the carcinogenic risks of chemicals remains important. Currently, substantial progress has been made in identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c77e0abb3a2060a24f00634c99901517
https://pubmed.ncbi.nlm.nih.gov/28013212
https://pubmed.ncbi.nlm.nih.gov/28013212
Autor:
Svitlana Shpyleva, Frederick A. Beland, Vasyl F. Chekhun, Volodymyr Tryndyak, Igor P. Pogribny, Natalia Yu. Lukyanova, N. A. Bezdenezhnykh, Аnatoliy P. Burlaka
Publikováno v:
International Journal of Oncology. 43:1481-1486
The development of resistance of cancer cells to therapeutic agents is the major obstacle in the successful treatment of breast cancer and the main cause of breast cancer recurrence. The results of several studies have demonstrated an important role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad34c0c6e6e8e13a42f9da5e242b0e83
https://doi.org/10.3892/ijo.2013.2063
https://doi.org/10.3892/ijo.2013.2063
Autor:
Svitlana Shpyleva, Igor P. Pogribny, Gonçalo Gamboa da Costa, Frederick A. Beland, Marta Pogribna, Volodymyr P. Tryndyak, Gordon Surratt
Publikováno v:
International Journal of Oncology. 42:1822-1832
Iron plays a vital role in the normal functioning of cells via the regulation of essential cellular metabolic reactions, including several DNA and histone-modifying proteins. The metabolic status of iron and the regulation of epigenetic mechanisms ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c060a0237a0e94efd19c5e7f91557a28
https://doi.org/10.3892/ijo.2013.1855
https://doi.org/10.3892/ijo.2013.1855
Publikováno v:
Molecular neurobiology. 55(2)
Long interspersed nuclear elements-1 (LINE-1 or L1) are mobile DNA sequences that are capable of duplication and insertion (retrotransposition) within the genome. Recently, retrotransposition of L1 was shown to occur within human brain leading to som
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39053858a1a66a47e0ffaa3448a51ad
https://pubmed.ncbi.nlm.nih.gov/28220356
https://pubmed.ncbi.nlm.nih.gov/28220356