Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Svitlana Malyarchuk"'
Autor:
Madhurima Saxena, Kevin Pruitt, Mathieu Cameron Mehl, Xin Gu, Allison E. Wang, Ana Nedeljkovic-Kurepa, Kimberly R. Holloway, Svitlana Malyarchuk, Andreia Barbieri
Publikováno v:
Molecular Endocrinology. 27:480-490
Breast cancer remains one of the leading causes of death in women diagnosed with cancer. In breast cancer, aberrant expression of the CYP19A1 gene, which encodes the aromatase enzyme, contributes to increased intratumoral levels of estradiol. Regardl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ed8d2e5c6a19462667066a9c49ca47
https://doi.org/10.1210/me.2012-1347
https://doi.org/10.1210/me.2012-1347
Publikováno v:
Mutagenesis. 28:357-366
Clustered DNA lesions are defined as ≥2 damage events within 20 bp. Oxidised bases, abasic (AP) sites, single-strand breaks and double-strand breaks (DSBs) exist in radiation-induced clusters, and these lesions are more difficult to repair and can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b7a2f5efeaa3c632d19992f0e4c802
https://doi.org/10.1093/mutage/get009
https://doi.org/10.1093/mutage/get009
Publikováno v:
Nucleic Acids Research
Clustered lesions are defined astwo lesions within 20bps and are generated in DNA by ionizing radia- tion. In vitro studies and work in bacteria have shown that attempted repair of two closely opposed lesions can result in the formation of double str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8431649695a9b2e31d3ccfaa25ceed3
https://doi.org/10.1093/nar/gkn450
https://doi.org/10.1093/nar/gkn450
Autor:
Svitlana Malyarchuk, Lynn Harrison
Publikováno v:
Journal of Molecular Biology. 345:731-743
Two or more base damages, abasic sites or single-strand breaks (SSBs) within two helical turns of the DNA form a multiply damaged site (MDS) or clustered lesion. Studies in vitro and in bacteria indicate that attempts to repair two closely opposed ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee4ea3435615226869ac9db208d5e2f
https://doi.org/10.1016/j.jmb.2004.10.079
https://doi.org/10.1016/j.jmb.2004.10.079
Autor:
Svitlana Malyarchuk, Lynn Harrison
Publikováno v:
Pathophysiology. 8:149-159
Production of DNA damage is the basis of cancer treatments, such as chemotherapy and radiotherapy. The limitation of the treatment dose tends to be how well the normal cells within the body can tolerate the therapy. Although it is possible, to some e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbedef9aae90d53a111aed14e5c8e5c
https://doi.org/10.1016/s0928-4680(01)00079-7
https://doi.org/10.1016/s0928-4680(01)00079-7
Autor:
James A. Cardelli, Kevin Pruitt, Allison E. Wang, Svitlana Malyarchuk, Samantha S. Dykes, Madhurima Saxena
Publikováno v:
Oncogene
Rac1-GTPases serve as intermediary cellular switches, which conduct transient and constitutive signals from upstream cues, including those from Ras oncoproteins. Although the sirtuin1 (SIRT1) deacetylase is overexpressed in several human cancers and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a1cf0da39b7d4c7eadd7c9532179fa
https://pubmed.ncbi.nlm.nih.gov/24362520
https://pubmed.ncbi.nlm.nih.gov/24362520
Publikováno v:
Cancer Research. 76:A19-A19
Tumorigenesis stems from errors incorporated in the genetic code and impaired epigenetic mechanisms involved in tumor suppression. Mutation in methyl-CpG-binding protein 2 (MeCP2) is known to cause a neurological disorder, rett syndrome (RTT), howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d673434e90fe5a886c43eb854714ed9
https://doi.org/10.1158/1538-7445.chromepi15-a19
https://doi.org/10.1158/1538-7445.chromepi15-a19
Publikováno v:
DNA repair. 8(12)
Current data indicate that clustered DNA damage generated by ionizing radiation contains 2–5 damages within 20 bps. The complexity of clustered damage is also believed to increase as the linear energy transfer of the radiation increases. Complex le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4dc0834c2b454ed07d3093d5f8f2389
https://pubmed.ncbi.nlm.nih.gov/19800300
https://pubmed.ncbi.nlm.nih.gov/19800300
Autor:
Svitlana Malyarchuk, Reneau Castore, Aidan J. Doherty, Bernard Weiss, Emily Klepper, Douglas G. Wright, Lynn Harrison
Unlike Escherichia coli, Mycobacterium tuberculosis (Mt) expresses a Ku-like protein and an ATP-dependent DNA ligase that can perform non-homologous end-joining (NHEJ). We have expressed the Mt-Ku and Mt-Ligase D in E. coli using an arabinose-inducib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee58bd3a5637abf4ba227490a0918ab
https://europepmc.org/articles/PMC2739044/
https://europepmc.org/articles/PMC2739044/
Publikováno v:
Nucleic acids research. 32(19)
Multiply damaged sites (MDSs) are generated in DNA by ionizing radiation. In vitro studies predict that base excision repair in cells will convert MDSs to lethal double strand breaks (DSBs) when two opposing base damages are situated ≥2 bp apart. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2133d8f4c1a4b0bc62b0092471bfdab
https://pubmed.ncbi.nlm.nih.gov/15509868
https://pubmed.ncbi.nlm.nih.gov/15509868