Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Svitlana, Tyekucheva"'
Autor:
Roberta S. Azevedo, Francesca Morelli, Kiyomi Mashima, Rayan Fardoun, Svitlana Tyekucheva, Stacey Fernandes, Samantha Shupe, Marissa Terra, Anisha Patel, Matthew S. Davids, Joseph Yu, Jennifer R. Brown
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Chronic lymphocytic leukemia (CLL) patients have an increased risk of secondary cancers, along with predisposition to CLL in their relatives. We have previously identified germline ATM variants as associated with CLL risk; here, we present their impa
Externí odkaz:
https://doaj.org/article/97a85dd3b87e4eada3214a8ce2c22660
Autor:
Teemu D. Laajala, Varsha Sreekanth, Alex C. Soupir, Jordan H. Creed, Anni S. Halkola, Federico C. F. Calboli, Kalaimathy Singaravelu, Michael V. Orman, Christelle Colin-Leitzinger, Travis Gerke, Brooke L. Fridley, Svitlana Tyekucheva, James C. Costello
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-13 (2023)
Abstract Genomic and transcriptomic data have been generated across a wide range of prostate cancer (PCa) study cohorts. These data can be used to better characterize the molecular features associated with clinical outcomes and to test hypotheses acr
Externí odkaz:
https://doaj.org/article/74d7b11469474de8bb6ff94431c8476f
Autor:
Deepti Gadi, Stephen P. Martindale, Pui Yan Chiu, Jasneet Khalsa, Pei-Hsuan Chen, Stacey M. Fernandes, Zixu Wang, Svitlana Tyekucheva, John-Hanson Machado, David C. Fisher, Philippe Armand, Matthew S. Davids, Scott Rodig, Barbara Sherry, Jennifer R. Brown
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract PI3Kδ inhibitors are approved for the therapy of B cell malignancies, but their clinical use has been limited by unpredictable autoimmune toxicity, despite promising efficacy and evidence that toxicity is associated with improved clinical o
Externí odkaz:
https://doaj.org/article/94914f0b3bca45c9ad51c3edd14b1ac9
Autor:
Eddie Luidy Imada, Diego Fernando Sanchez, Wikum Dinalankara, Thiago Vidotto, Ericka M. Ebot, Svitlana Tyekucheva, Gloria Regina Franco, Lorelei Ann Mucci, Massimo Loda, Edward Matthew Schaeffer, Tamara Lotan, Luigi Marchionni
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background PTEN is the most frequently lost tumor suppressor in primary prostate cancer (PCa) and its loss is associated with aggressive disease. However, the transcriptional changes associated with PTEN loss in PCa have not been described i
Externí odkaz:
https://doaj.org/article/691966c326904d4cbfd10d1a8e31843d
Autor:
Konrad H Stopsack, Svitlana Tyekucheva, Molin Wang, Travis A Gerke, J Bailey Vaselkiv, Kathryn L Penney, Philip W Kantoff, Stephen P Finn, Michelangelo Fiorentino, Massimo Loda, Tamara L Lotan, Giovanni Parmigiani, Lorelei A Mucci
Publikováno v:
eLife, Vol 10 (2021)
Tissue microarrays (TMAs) have been used in thousands of cancer biomarker studies. To what extent batch effects, measurement error in biomarker levels between slides, affects TMA-based studies has not been assessed systematically. We evaluated 20 pro
Externí odkaz:
https://doaj.org/article/5d3559e372204133ba3415106d7b03ea
Autor:
Aishath Naeem, Filippo Utro, Qing Wang, Justin Cha, Mauno Vihinen, Stephen Martindale, Yinglu Zhou, Yue Ren, Svitlana Tyekucheva, Annette S. Kim, Stacey M. Fernandes, Gordon Saksena, Kahn Rhrissorrakrai, Chaya Levovitz, Brian P. Danysh, Kara Slowik, Raquel A. Jacobs, Matthew S. Davids, James A. Lederer, Rula Zain, C. I. Edvard Smith, Ignaty Leshchiner, Laxmi Parida, Gad Getz, Jennifer R. Brown
Publikováno v:
Blood Advances. 7:1929-1943
Covalent inhibitors of Bruton tyrosine kinase (BTK) have transformed the therapy of chronic lymphocytic leukemia (CLL), but continuous therapy has been complicated by the development of resistance. The most common resistance mechanism in patients who
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8383f4c725051ef015310abdc3f2d39
https://doi.org/10.1182/bloodadvances.2022008447
https://doi.org/10.1182/bloodadvances.2022008447
Autor:
Benjamin L. Lampson, Aditi Gupta, Svitlana Tyekucheva, Kiyomi Mashima, Anna Petráčková, Zixu Wang, Natalia Wojciechowska, Conner J. Shaughnessy, Peter O. Baker, Stacey M. Fernandes, Samantha Shupe, John-Hanson Machado, Rayan Fardoun, Annette S. Kim, Jennifer R. Brown
Publikováno v:
Journal of Clinical Oncology. 41:1116-1128
PURPOSE Germline missense variants of unknown significance in cancer-related genes are increasingly being identified with the expanding use of next-generation sequencing. The ataxia telangiectasia–mutated ( ATM) gene on chromosome 11 has more than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c834bcfab54c576b3ae2d84bf3e046b
https://doi.org/10.1200/jco.22.00269
https://doi.org/10.1200/jco.22.00269
Autor:
Christine E. Ryan, Danielle M. Brander, Paul M. Barr, Svitlana Tyekucheva, Liam R. Hackett, Mary C. Collins, Stacey M. Fernandes, Yue Ren, Yinglu Zhou, Mikaela M. McDonough, Heather A. Walker, Monica R. McEwan, Jeremy S. Abramson, Eric D. Jacobsen, Ann S. LaCasce, David C. Fisher, Jennifer R. Brown, Matthew S. Davids
Publikováno v:
Leukemia. 37:835-842
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcd9c6e487a35c7c8dba1553e3108c27
https://doi.org/10.1038/s41375-023-01830-2
https://doi.org/10.1038/s41375-023-01830-2
Autor:
Zeya Wang, Shaolong Cao, Jeffrey S. Morris, Jaeil Ahn, Rongjie Liu, Svitlana Tyekucheva, Fan Gao, Bo Li, Wei Lu, Ximing Tang, Ignacio I. Wistuba, Michaela Bowden, Lorelei Mucci, Massimo Loda, Giovanni Parmigiani, Chris C. Holmes, Wenyi Wang
Publikováno v:
iScience, Vol 9, Iss , Pp 451-460 (2018)
Summary: Transcriptome deconvolution in cancer and other heterogeneous tissues remains challenging. Available methods lack the ability to estimate both component-specific proportions and expression profiles for individual samples. We present DeMixT,
Externí odkaz:
https://doaj.org/article/04660eb59a434b3aaa6071ef528c231e
Autor:
Chaoran Ma, Yinglu Zhou, Giuseppe Nicolò Fanelli, Konrad H. Stopsack, Michelangelo Fiorentino, Giorgia Zadra, Lorelei A. Mucci, Massimo Loda, Svitlana Tyekucheva, Kathryn L. Penney
Publikováno v:
Molecular Cancer Research. 21:253-260
Prostate cancer has a heterogeneous prognosis. Most previous studies have focused on the identification of prognostic biomarkers in the prostate cancer tumor. However, it is increasingly recognized that the tumor microenvironment contributes to prost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7521cf317be64dbf44be692394d4303
https://doi.org/10.1158/1541-7786.mcr-22-0627
https://doi.org/10.1158/1541-7786.mcr-22-0627