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Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non-disease-specific pathway of functional neurologic improvement.

Autor: Fine JM; Neuroscience Research at HealthPartners Institute, Saint Paul, MN, USA., Kosyakovsky J; Neuroscience Research at HealthPartners Institute, Saint Paul, MN, USA., Baillargeon AM; Neuroscience Research at HealthPartners Institute, Saint Paul, MN, USA., Tokarev JV; Neuroscience Research at HealthPartners Institute, Saint Paul, MN, USA., Cooner JM; Neuroscience Research at HealthPartners Institute, Saint Paul, MN, USA., Svitak AL; Neuroscience Research at HealthPartners Institute, Saint Paul, MN, USA., Faltesek KA; Neuroscience Research at HealthPartners Institute, Saint Paul, MN, USA., Frey WH 2nd; Neuroscience Research at HealthPartners Institute, Saint Paul, MN, USA., Hanson LR; Neuroscience Research at HealthPartners Institute, Saint Paul, MN, USA.

Publikováno v: Brain and behavior [Brain Behav] 2020 Mar; Vol. 10 (3), pp. e01536. Date of Electronic Publication: 2020 Jan 20.

Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats.

Autor: Rautiola D; Departments of Pharmaceutics (D.R., R.A.S.), Experimental and Clinical Pharmacology (J.C.C.), Medicinal Chemistry (N.C., K.M.N., G.I.G.), and Biomedical Engineering (R.A.S.), Center for Orphan Drug Research (P.D.M., U.M., L.D.C., J.C.C.), and Institute for Therapeutics Discovery and Development (N.C., K.M.N., G.I.G.), University of Minnesota, Minneapolis, Minnesota; and Neuroscience Research, HealthPartners Institute, St. Paul, Minnesota (J.M.F., A.L.S., K.A.F., L.R.H.)., Maglalang PD; Departments of Pharmaceutics (D.R., R.A.S.), Experimental and Clinical Pharmacology (J.C.C.), Medicinal Chemistry (N.C., K.M.N., G.I.G.), and Biomedical Engineering (R.A.S.), Center for Orphan Drug Research (P.D.M., U.M., L.D.C., J.C.C.), and Institute for Therapeutics Discovery and Development (N.C., K.M.N., G.I.G.), University of Minnesota, Minneapolis, Minnesota; and Neuroscience Research, HealthPartners Institute, St. Paul, Minnesota (J.M.F., A.L.S., K.A.F., L.R.H.)., Cheryala N; Departments of Pharmaceutics (D.R., R.A.S.), Experimental and Clinical Pharmacology (J.C.C.), Medicinal Chemistry (N.C., K.M.N., G.I.G.), and Biomedical Engineering (R.A.S.), Center for Orphan Drug Research (P.D.M., U.M., L.D.C., J.C.C.), and Institute for Therapeutics Discovery and Development (N.C., K.M.N., G.I.G.), University of Minnesota, Minneapolis, Minnesota; and Neuroscience Research, HealthPartners Institute, St. Paul, Minnesota (J.M.F., A.L.S., K.A.F., L.R.H.)., Nelson KM; Departments of Pharmaceutics (D.R., R.A.S.), Experimental and Clinical Pharmacology (J.C.C.), Medicinal Chemistry (N.C., K.M.N., G.I.G.), and Biomedical Engineering (R.A.S.), Center for Orphan Drug Research (P.D.M., U.M., L.D.C., J.C.C.), and Institute for Therapeutics Discovery and Development (N.C., K.M.N., G.I.G.), University of Minnesota, Minneapolis, Minnesota; and Neuroscience Research, HealthPartners Institute, St. Paul, Minnesota (J.M.F., A.L.S., K.A.F., L.R.H.)., Georg GI; Departments of Pharmaceutics (D.R., R.A.S.), Experimental and Clinical Pharmacology (J.C.C.), Medicinal Chemistry (N.C., K.M.N., G.I.G.), and Biomedical Engineering (R.A.S.), Center for Orphan Drug Research (P.D.M., U.M., L.D.C., J.C.C.), and Institute for Therapeutics Discovery and Development (N.C., K.M.N., G.I.G.), University of Minnesota, Minneapolis, Minnesota; and Neuroscience Research, HealthPartners Institute, St. Paul, Minnesota (J.M.F., A.L.S., K.A.F., L.R.H.)., Fine JM; Departments of Pharmaceutics (D.R., R.A.S.), Experimental and Clinical Pharmacology (J.C.C.), Medicinal Chemistry (N.C., K.M.N., G.I.G.), and Biomedical Engineering (R.A.S.), Center for Orphan Drug Research (P.D.M., U.M., L.D.C., J.C.C.), and Institute for Therapeutics Discovery and Development (N.C., K.M.N., G.I.G.), University of Minnesota, Minneapolis, Minnesota; and Neuroscience Research, HealthPartners Institute, St. Paul, Minnesota (J.M.F., A.L.S., K.A.F., L.R.H.)., Svitak AL; Departments of Pharmaceutics (D.R., R.A.S.), Experimental and Clinical Pharmacology (J.C.C.), Medicinal Chemistry (N.C., K.M.N., G.I.G.), and Biomedical Engineering (R.A.S.), Center for Orphan Drug Research (P.D.M., U.M., L.D.C., J.C.C.), and Institute for Therapeutics Discovery and Development (N.C., K.M.N., G.I.G.), University of Minnesota, Minneapolis, Minnesota; and Neuroscience Research, HealthPartners Institute, St. Paul, Minnesota (J.M.F., A.L.S., K.A.F., L.R.H.)., Faltesek KA; Departments of Pharmaceutics (D.R., R.A.S.), Experimental and Clinical Pharmacology (J.C.C.), Medicinal Chemistry (N.C., K.M.N., G.I.G.), and Biomedical Engineering (R.A.S.), Center for Orphan Drug Research (P.D.M., U.M., L.D.C., J.C.C.), and Institute for Therapeutics Discovery and Development (N.C., K.M.N., G.I.G.), University of Minnesota, Minneapolis, Minnesota; and Neuroscience Research, HealthPartners Institute, St. Paul, Minnesota (J.M.F., A.L.S., K.A.F., L.R.H.)., Hanson LR; Departments of Pharmaceutics (D.R., R.A.S.), Experimental and Clinical Pharmacology (J.C.C.), Medicinal Chemistry (N.C., K.M.N., G.I.G.), and Biomedical Engineering (R.A.S.), Center for Orphan Drug Research (P.D.M., U.M., L.D.C., J.C.C.), and Institute for Therapeutics Discovery and Development (N.C., K.M.N., G.I.G.), University of Minnesota, Minneapolis, Minnesota; and Neuroscience Research, HealthPartners Institute, St. Paul, Minnesota (J.M.F., A.L.S., K.A.F., L.R.H.)., Mishra U; Departments of Pharmaceutics (D.R., R.A.S.), Experimental and Clinical Pharmacology (J.C.C.), Medicinal Chemistry (N.C., K.M.N., G.I.G.), and Biomedical Engineering (R.A.S.), Center for Orphan Drug Research (P.D.M., U.M., L.D.C., J.C.C.), and Institute for Therapeutics Discovery and Development (N.C., K.M.N., G.I.G.), University of Minnesota, Minneapolis, Minnesota; and Neuroscience Research, HealthPartners Institute, St. Paul, Minnesota (J.M.F., A.L.S., K.A.F., L.R.H.)., Coles LD; Departments of Pharmaceutics (D.R., R.A.S.), Experimental and Clinical Pharmacology (J.C.C.), Medicinal Chemistry (N.C., K.M.N., G.I.G.), and Biomedical Engineering (R.A.S.), Center for Orphan Drug Research (P.D.M., U.M., L.D.C., J.C.C.), and Institute for Therapeutics Discovery and Development (N.C., K.M.N., G.I.G.), University of Minnesota, Minneapolis, Minnesota; and Neuroscience Research, HealthPartners Institute, St. Paul, Minnesota (J.M.F., A.L.S., K.A.F., L.R.H.)., Cloyd JC; Departments of Pharmaceutics (D.R., R.A.S.), Experimental and Clinical Pharmacology (J.C.C.), Medicinal Chemistry (N.C., K.M.N., G.I.G.), and Biomedical Engineering (R.A.S.), Center for Orphan Drug Research (P.D.M., U.M., L.D.C., J.C.C.), and Institute for Therapeutics Discovery and Development (N.C., K.M.N., G.I.G.), University of Minnesota, Minneapolis, Minnesota; and Neuroscience Research, HealthPartners Institute, St. Paul, Minnesota (J.M.F., A.L.S., K.A.F., L.R.H.)., Siegel RA; Departments of Pharmaceutics (D.R., R.A.S.), Experimental and Clinical Pharmacology (J.C.C.), Medicinal Chemistry (N.C., K.M.N., G.I.G.), and Biomedical Engineering (R.A.S.), Center for Orphan Drug Research (P.D.M., U.M., L.D.C., J.C.C.), and Institute for Therapeutics Discovery and Development (N.C., K.M.N., G.I.G.), University of Minnesota, Minneapolis, Minnesota; and Neuroscience Research, HealthPartners Institute, St. Paul, Minnesota (J.M.F., A.L.S., K.A.F., L.R.H.) siege017@umn.edu.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2019 Sep; Vol. 370 (3), pp. 796-805. Date of Electronic Publication: 2019 Mar 05.

Food consumption and activity levels increase in rats following intranasal Hypocretin-1.

Autor: Dhuria SV; HealthPartners Institute for Education and Research, Center for Memory and Aging, Regions Hospital, 640 Jackson St., St. Paul, MN 55101, United States., Fine JM; HealthPartners Institute for Education and Research, Center for Memory and Aging, Regions Hospital, 640 Jackson St., St. Paul, MN 55101, United States., Bingham D; Center for Immunochemistry, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, United States., Svitak AL; HealthPartners Institute for Education and Research, Center for Memory and Aging, Regions Hospital, 640 Jackson St., St. Paul, MN 55101, United States., Burns RB; HealthPartners Institute for Education and Research, Center for Memory and Aging, Regions Hospital, 640 Jackson St., St. Paul, MN 55101, United States., Baillargeon AM; HealthPartners Institute for Education and Research, Center for Memory and Aging, Regions Hospital, 640 Jackson St., St. Paul, MN 55101, United States., Panter SS; Center for Immunochemistry, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, United States., Kazi AN; HealthPartners Institute for Education and Research, Center for Memory and Aging, Regions Hospital, 640 Jackson St., St. Paul, MN 55101, United States., Frey WH 2nd; HealthPartners Institute for Education and Research, Center for Memory and Aging, Regions Hospital, 640 Jackson St., St. Paul, MN 55101, United States., Hanson LR; HealthPartners Institute for Education and Research, Center for Memory and Aging, Regions Hospital, 640 Jackson St., St. Paul, MN 55101, United States. Electronic address: Leah.R.Hanson@HealthPartners.com.

Publikováno v: Neuroscience letters [Neurosci Lett] 2016 Aug 03; Vol. 627, pp. 155-9. Date of Electronic Publication: 2016 Jun 02.

Intranasal delivery of insulin via the olfactory nerve pathway.

Autor: Renner DB; Alzheimer's Research Center at Regions Hospital, HealthPartners Research Foundation, St Paul, MN 55101, USA. dan.b.renner@healthpartners.com, Svitak AL, Gallus NJ, Ericson ME, Frey WH 2nd, Hanson LR

Publikováno v: The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2012 Dec; Vol. 64 (12), pp. 1709-14. Date of Electronic Publication: 2012 Jul 04.