Výsledky vyhledávání - "Svilen Angelov"

Akademický článek

Uncoupling the Excitatory Amino Acid Transporter 2 From Its C-Terminal Interactome Restores Synaptic Glutamate Clearance at Corticostriatal Synapses and Alleviates Mutant Huntingtin-Induced Hypokinesia

Autor: Stefan Hirschberg, Anton Dvorzhak, Seyed M. A. Rasooli-Nejad, Svilen Angelov, Marieluise Kirchner, Philipp Mertins, Gilla Lättig-Tünnemann, Christoph Harms, Dietmar Schmitz, Rosemarie Grantyn

Publikováno v: Frontiers in Cellular Neuroscience, Vol 15 (2022)

Rapid removal of glutamate from the sites of glutamate release is an essential step in excitatory synaptic transmission. However, despite many years of research, the molecular mechanisms underlying the intracellular regulation of glutamate transport

Externí odkaz: https://doaj.org/article/910348cd39c74f56bb7d8307a8c6d81c

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Publikováno v: Frontiers in cellular neuroscience 15, 792652 (2022). doi:10.3389/fncel.2021.792652
Frontiers in Cellular Neuroscience, Vol 15 (2022)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6517c1f6a8cf8e1e91300ff625d3b643
https://pubmed.ncbi.nlm.nih.gov/35173582

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Expression of a modified astrocytic glutamate transporter alleviates Huntington’s hypokinesia, promotes synaptic glutamate clearance and counteracts potentially adverse EAAT2 interactions

Autor: Dietmar Schmitz, Anton Dvorzhak, Svilen Angelov, Christoph Harms, Gilla Lättig-Tünnemann, Rosemarie Grantyn, Stefan Hirschberg, Seyed M.A. Rasooli-Nejad, Philip Mertins, Marieluise Kirchner

SUMMARYRapid removal of glutamate from the sites of glutamate release is an essential step in excitatory synaptic transmission. Despite many years of research, the molecular mechanisms underlying the intracellular regulation of glutamate transport at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc7bb8792f50e03725bf7873c6bfb26a
https://doi.org/10.1101/2020.09.17.302158

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C-Terminal-Dependent Control of EAAT2 Signaling, Corticostriatal Synaptic Glutamate Clearance and Spontaneous Motor Activity in Mice with Hypokinesia

Autor: Stefan Hirschberg, Rosemarie Grantyn, Anton Dvorzhak, Gilla Lättig-Tünnemann, Svilen Angelov, Christoph Harms, Philip Mertins, Marieluise Kirchner, Dietmar Schmitz, Seyed M.A. Rasooli-Nejad

Publikováno v: SSRN Electronic Journal.

Deficiency of the astrocytic excitatory amino acid transporter type 2 (EAAT2) and, consequently, inefficient glutamate clearance at corticostriatal synapses may contribute to the depression of self-initiated movements in Huntington’s disease (HD).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0aee5f6497a2eeb8f10f1eb1cd79dfea
https://doi.org/10.2139/ssrn.3704013

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