Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Svetlana Z. Stepanovic"'
Autor:
Corey R. Hopkins, Sabina Kupershmidt, Sebastien Chaigne, Svetlana Z. Stepanovic, Jeffrey R. Balser, Alfred L. George, Franck Potet, Amanda Lorinc, Craig W. Lindsley, David Afshartous, Darren W. Engers, L. Michelle Lewis, Franz J. Baudenbacher, Veniamin Y. Sidorov, Courtney M. Campbell, Min Li, Beiyan Zou, C. David Weaver, Emily Days, Raghav Venkataraman
Publikováno v:
Journal of Biological Chemistry. 287:39613-39625
The human Ether-à-go-go-related gene (hERG)-encoded K(+) current, I(Kr) is essential for cardiac repolarization but is also a source of cardiotoxicity because unintended hERG inhibition by diverse pharmaceuticals can cause arrhythmias and sudden car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2169d182cf60a442f3ad234e4f93aa
https://doi.org/10.1074/jbc.m112.380162
https://doi.org/10.1074/jbc.m112.380162
Autor:
Jens Meiler, Sabina Kupershmidt, Jeffrey R. Balser, Christina I. Petersen, Jarrod A. Smith, Svetlana Z. Stepanovic, Franck Potet
Publikováno v:
The Journal of Physiology. 587:2555-2566
Human ether-a-go-go-related gene (HERG) encodes the rapid, outwardly rectifying K+ current IKr that is critical for repolarization of the cardiac action potential. Congenital HERG mutations or unintended pharmaceutical block of IKr can lead to life-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd80d96f91a0763a351d0c6838039c25
https://doi.org/10.1113/jphysiol.2008.166694
https://doi.org/10.1113/jphysiol.2008.166694
Autor:
Walter J. Chazin, Jeffrey R. Balser, Prakash C. Viswanathan, Sabina Kupershmidt, Svetlana Z. Stepanovic, Benjamin Chagot, Mircea Anghelescu, Franck Potet
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (13), pp.8846-8854. ⟨10.1074/jbc.M806871200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (13), pp.8846-8854. ⟨10.1074/jbc.M806871200⟩
Sodium channels are fundamental signaling molecules in excitable cells, and are molecular targets for local anesthetic agents and intracellular free Ca(2+) ([Ca(2+)](i)). Two regions of Na(V)1.5 have been identified previously as [Ca(2+)](i)-sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c9fa1485d7a0333e07ef0a8821da78
https://doi.org/10.1074/jbc.m806871200
https://doi.org/10.1074/jbc.m806871200
Autor:
Franck Potet, Jeffrey R. Balser, Wen Shuai, Svetlana Z. Stepanovic, Sabina Kupershmidt, Christina I. Petersen, Olivier Boutaud
Publikováno v:
Journal of Molecular and Cellular Cardiology. 46:257-267
The human ether-a-go-go related gene (HERG) constitutes the pore forming subunit of I(Kr), a K(+) current involved in repolarization of the cardiac action potential. While mutations in HERG predispose patients to cardiac arrhythmias (Long QT syndrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75d1b8fa2edb81a1a05b31773266ba4
https://doi.org/10.1016/j.yjmcc.2008.10.015
https://doi.org/10.1016/j.yjmcc.2008.10.015
Publikováno v:
Biophysical Journal. 108(2)
The cardiac sodium channel (Nav1.5) has a complex ‘intracellular Ca2+ sensing apparatus’ within its C-terminal domain (CTD) consisting of a partial EF-hand domain (CTD-EF) and a calmodulin (CaM) binding IQ motif (CTD-IQ). There are additional CaM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8067e2e3b4f64d2db14c83b5cd39c69
Autor:
Alfred L. George, Svetlana Z. Stepanovic, Franklin M. Mullins, Niloufar B. Gillani, Jeffrey R. Balser
Publikováno v:
The Journal of Physiology. 558:729-744
We have studied the interaction between extracellular K+ (K+o) and extracellular Na+ (Na+o) in human ether-a-go-go related gene (HERG)-encoded K+ channels expressed in Chinese hamster ovary (CHO-K1) cells, using the whole-cell voltage clamp technique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afbe902bf69d9717434b3e666d5b12ab
https://doi.org/10.1113/jphysiol.2004.065193
https://doi.org/10.1113/jphysiol.2004.065193
Autor:
Svetlana Z. Stepanovic, Franklin M. Mullins, Jeffrey R. Balser, Alfred L. George, Reshma R. Desai
Publikováno v:
The Journal of General Physiology
Most voltage-gated K(+) currents are relatively insensitive to extracellular Na(+) (Na(+)(o)), but Na(+)(o) potently inhibits outward human ether-a-go-go-related gene (HERG)-encoded K(+) channel current (Numaguchi, H., J.P. Johnson, Jr., C.I. Peterse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da56598d95f2ec320da4985ced7e097
https://doi.org/10.1085/jgp.20028589
https://doi.org/10.1085/jgp.20028589
Autor:
Rong Zhang, Mark E. Anderson, Dan M. Roden, Svetlana Z. Stepanovic, Sabina Kupershmidt, Arthur A.M. Wilde, Hanno L. Tan, Jeffrey R. Balser
Publikováno v:
Nature, 415(6870), 442-447. Nature Publishing Group
Sodium channels are principal molecular determinants responsible for myocardial conduction and maintenance of the cardiac rhythm. Calcium ions (Ca2+) have a fundamental role in the coupling of cardiac myocyte excitation and contraction, yet mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85733302bdae0c9dc6d622a0e375599c
https://doi.org/10.1038/415442a
https://doi.org/10.1038/415442a
Autor:
Laura A. Hastings, Svetlana Z. Stepanovic, Gordon F. Tomaselli, Eduardo Marbán, Nicholas G. Kambouris, Jeffrey R. Balser
Publikováno v:
The Journal of Physiology. 512:693-705
1. Mutations that disrupt Na+ channel fast inactivation attenuate lidocaine (lignocaine)-induced use dependence; however, the pharmacological role of slower inactivation processes remains unclear. In Xenopus oocytes, tryptophan substitution in the ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d966ac172a274239eeaad294ebb9b77
https://doi.org/10.1111/j.1469-7793.1998.693bd.x
https://doi.org/10.1111/j.1469-7793.1998.693bd.x
Mapping Residues that Influence Fast Inactivation Within Ca-Sensing Domains in the Nav1.5 C-Terminus
Publikováno v:
Biophysical Journal. 100(3)
Dysfunction of the cardiac sodium channel (NaV1.5, SCN5A) can result in arrhythmias. We previously identified a complex ‘[Ca2+]i sensing apparatus’ within the C-terminal domain (CTD) and have linked structural changes occurring in response to [Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc33682643f842b5fc4384102eb698b