Na,K-ATPase as a target for endogenous cardiotonic steroids: What's the evidence?

Autor: Sergei N. Orlov, Artem M. Tverskoi, Svetlana V. Sidorenko, Larisa V. Smolyaninova, Olga D. Lopina, Nickolai O. Dulin, Elizaveta A. Klimanova

Publikováno v: Genes and Diseases, Vol 8, Iss 3, Pp 259-271 (2021)

With an exception of few reports, the plasma concentration of ouabain and marinobufagenin, mostly studied cardiotonic steroids (CTS) assessed by immunoassay techniques, is less than 1 nM. During the last 3 decades, the implication of these endogenous

Externí odkaz: https://doaj.org/article/06ca50ef462249b5824f467527df1996

Deoxygenation Affects Composition of Membrane-Bound Proteins in Human Erythrocytes

Autor: Oksana G. Luneva, Svetlana V. Sidorenko, Olga O. Ponomarchuk, Artem M. Tverskoy, Aleksander A. Cherkashin, Oleg V. Rodnenkov, Natalia V. Alekseeva, Leonid I. Deev, Georgy V. Maksimov, Ryszard Grygorczyk, Sergei N. Orlov

Publikováno v: Cellular Physiology and Biochemistry, Vol 39, Iss 1, Pp 81-88 (2016)

Background/Aims: ATP release from erythrocyte plays a key role in hypoxia-induced elevation of blood flow in systematic circulation. We have previously shown that hemolysis contributes to erythrocyte ATP release triggered by several stimuli, includin

Externí odkaz: https://doaj.org/article/c9f570387dd543bb9f38f328e0891643

Increased Extracellular Sodium Concentration as a Factor Regulating Gene Expression in Endothelium

Autor: Dmitry A. Fedorov, Svetlana V. Sidorenko, Alexander I. Yusipovich, Olesya V. Bukach, Andrey M. Gorbunov, Olga D. Lopina, Elizaveta A. Klimanova

Publikováno v: Biochemistry. Biokhimiia. 87(6)

Hyperosmotic stimulation of endothelial cells often leads to its dysfunction accompanied, among other things, by proinflammatory response. The mechanisms of this phenomenon are not fully understood. It may arise due to increase in the plasma Na+ conc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a7a7fd190a65d9924ca529e700479d
https://pubmed.ncbi.nlm.nih.gov/35790409

Effects of Dynamic and Static Loads on the Concentration of Sodium and Potassium in Murine Skeletal Muscles

Autor: A. N. Zakharova, Kseniya Milovanova, Leonid V. Kapilevich, T. A. Kironenko, D A Fedorov, Svetlana V. Sidorenko, E. Yu. Dyakova, N S Orlov

Publikováno v: Bulletin of Experimental Biology and Medicine. 169:1-4

The effects of dynamic and static load on the intracellular concentrations of sodium [Formula: see text] and potassium (K+i) in m. soleus and m. biceps, respectively, were studied in mice. Both dynamic (swimming for 60 min) and static (hanging on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79965a0b87b2c155bfe98df9a7e05855
https://doi.org/10.1007/s10517-020-04811-y

Elevation of Intracellular Na+ Contributes to Expression of Early Response Genes Triggered by Endothelial Cell Shrinkage

Autor: Ryszard Grygorczyk, A. A. Shiyan, Sergei N. Orlov, E. A. Klimanova, Larisa V. Smolyaninova, Dmitry Fedorov, Svetlana V. Sidorenko, Leonid V. Kapilevich

Publikováno v: Cellular Physiology and Biochemistry, Vol 53, Iss 4, Pp 638-647 (2019)
Cellular physiology and biochemistry. 2019. Vol. 53, № 4. P. 638-647

Background/aims Prolonged hyperosmotic shrinkage evokes expression of osmoprotective genes via nuclear factor NFAT5-mediated pathway and activates Na+ influx via hypertonicity-induced cation channels (HICC). In human umbilical vein endothelial cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed21a0df66cb2f2f3e29b1e04ed5e13
https://www.cellphysiolbiochem.com/Articles/000162/