Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Svetlana Slanina"'
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 22
International Journal of Molecular Sciences, Vol 22, Iss 12186, p 12186 (2021)
Volume 22
Issue 22
International Journal of Molecular Sciences, Vol 22, Iss 12186, p 12186 (2021)
The long-standing question in radiation and cancer biology is how principles of chromosome organization impact the formation of chromosomal aberrations (CAs). To address this issue, we developed a physical modeling approach and analyzed high-throughp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901f9d4b43883c36f334680a13c36808
http://europepmc.org/articles/PMC8618582
http://europepmc.org/articles/PMC8618582
The explanation for the compartmentalization of the chromosome contact maps observed by Hi-C method is still an unsolved mystery. The most natural and generally accepted explanation is that blocks of frequent/rare contacts on the entire map are assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df93902de5b8067ec2da5459dbcf4ea
How 3D chromosome organization affects chromosomal aberrations is an important unresolved question in cell and radiation biology. In interphase the chromosomes form territories where chromatin folds into quite heterogeneous states. The mechanisms det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db12f4ceb56888c15509a41561df947d
https://doi.org/10.1101/852277
https://doi.org/10.1101/852277
Publikováno v:
Supercomputing Frontiers and Innovations. 5
We present a polymer modeling approach to generate the ensemble of 3D chromosome conformations at different time points of mitosis-interphase transition. Dynamics of structure during mitosis-G1 transition indicates quick and slow stages of chromosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d245c1c3921224b916c3047742d0dc8
https://doi.org/10.14529/jsfi180305
https://doi.org/10.14529/jsfi180305
Publikováno v:
Supercomputing Frontiers and Innovations. 5
The origin of dose-response curves for radiation-induced chromosomal instability (CI) is studied using the mechanistic CI model. The model takes into account DNA damage generation and repair in the progeny of irradiated cells and cell passage through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::075b90f912d359e687bce678570006ba
https://doi.org/10.14529/jsfi180306
https://doi.org/10.14529/jsfi180306
In this paper, changes in a large-scale 3D structure of chromosomes during stem cell differentiation is studied. The polymer coarse-grained model of a human interphase chromosome is introduced which reproduces the experimental Hi-C contact maps in ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa30558cef3bfd07c4da8af5c94c96e
Different cell lines demonstrate various dose response for radiation-induced chromosomal instability (RICI). To clarify the origin of differences we analyzed own and published data on RICI for four cell lines, V79, TK6, WTK1 and CHO-K1 on the basis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a351f9b4276d281dd11c7cc2f04daba1
The question of to what extent large scale structure of interphase chromosomes contributes to chromosomal exchange aberrations is discussed for a long time but still remains unclear. We designed the polymer model of 3D organization of a mouse chromos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490282b836db1f6eea97310bcca3ad7e
https://doi.org/10.1101/223859
https://doi.org/10.1101/223859
The experimental observations demonstrate that different cell lines reveal various shape of dynamic curves for radiation-induced chromosomal instability (RICI). We analyzed our own and published data on RICI for three cell lines, CHO-K1, V79 and TK6,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badcb9e65b37cf3e5b7b693918d31026
The origin of dose-response curves for radiation-induced chromosomal instability (CI) is studied using the mechanistic CI model. The model takes into account DNA damage generation and repair in the progeny of irradiated cells, cell passage through mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4909e2885c7c6b08576ddf44f11312b