Rhodospirillum rubrum L-Asparaginase Conjugates with Polyamines of Improved Biocatalytic Properties as a New Promising Drug for the Treatment of Leukemia

Autor: Natalia V. Dobryakova, Dmitry D. Zhdanov, Nikolay N. Sokolov, Svetlana S. Aleksandrova, Marina V. Pokrovskaya, Elena V. Kudryashova

Publikováno v: Applied Sciences, Vol 13, Iss 5, p 3373 (2023)

L-asparaginase Rhodospirillum rubrum (RrA) is an enzyme (amidohydrolases; EC 3.5.1.1) that catalyzes the L-asparagine hydrolysis reaction to form L-aspartic acid. Due to the shortcomings of existing L-asparaginases from Esherichia coli (EcA) and Erwi

Externí odkaz: https://doaj.org/article/a2972d5afe564446a78c39aef6426168

Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions

Autor: Marina V. Pokrovskaya, Vadim S. Pokrovsky, Svetlana S. Aleksandrova, Nikolay N. Sokolov, Dmitry D. Zhdanov

Publikováno v: Pharmaceutics, Vol 14, Iss 3, p 599 (2022)

L-asparaginases (EC 3.5.1.1) are a family of enzymes that catalyze the hydrolysis of L-asparagine to L-aspartic acid and ammonia. These proteins with different biochemical, physicochemical and pharmacological properties are found in many organisms, i

Externí odkaz: https://doaj.org/article/564d670433004c62ac6e6cec22521742

Формирование коммуникативных универсальных учебных действий в современных учебниках для начальной школы

Autor: Svetlana S. Aleksandrova

Publikováno v: Society and Science: Future Development
Общество и наука: векторы развития

Статья раскрывает понятие «коммуникативные универсальные учебные действия», формирование которых ФГОС начального общего образования

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=interactivep::a2f9f7d4fd5de57ce555d7552635678d
https://interactive-plus.ru/article/559555/discussion_platform

Post-COVID Myocarditis in Patients with Primary Cardiomyopathies: Diagnosis, Clinical Course and Outcomes.

Autor: Blagova O; V.N. Vinogradov Faculty Therapeutic Clinic, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia., Lutokhina Y; V.N. Vinogradov Faculty Therapeutic Clinic, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia., Kogan E; Department of Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia., Savina P; V.N. Vinogradov Faculty Therapeutic Clinic, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia., Aleksandrova S; Department of Radiology, A. N. Bakulev National Medical Research Center for Cardiovascular Surgery of the Russian Ministry of Health, 121552 Moscow, Russia., Zaklyazminskaya E; Laboratory of Medical Genetics, B.V. Petrovsky Russian Research Center of Surgery, 119991 Moscow, Russia.

Publikováno v: Genes [Genes (Basel)] 2024 Aug 12; Vol. 15 (8). Date of Electronic Publication: 2024 Aug 12.

Highly Active Thermophilic L-Asparaginase from Melioribacter roseus Represents a Novel Large Group of Type II Bacterial L-Asparaginases from Chlorobi-Ignavibacteriae-Bacteroidetes Clade.

Autor: Dumina M; Group of Fungal Genetic Engineering, Federal Research Center 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, 117312 Moscow, Russia., Zhgun A; Group of Fungal Genetic Engineering, Federal Research Center 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, 117312 Moscow, Russia., Pokrovskaya M; Laboratory of Medical Biotechnology, Institute of Biomedical Chemistry, 119121 Moscow, Russia., Aleksandrova S; Laboratory of Medical Biotechnology, Institute of Biomedical Chemistry, 119121 Moscow, Russia., Zhdanov D; Laboratory of Medical Biotechnology, Institute of Biomedical Chemistry, 119121 Moscow, Russia., Sokolov N; Laboratory of Medical Biotechnology, Institute of Biomedical Chemistry, 119121 Moscow, Russia., El'darov M; Group of Fungal Genetic Engineering, Federal Research Center 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, 117312 Moscow, Russia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Dec 20; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 20.