Radioiodinated Exendin-4 Is Superior to the Radiometal-Labelled Glucagon-Like Peptide-1 Receptor Probes Overcoming Their High Kidney Uptake.

Autor: Tilman Läppchen, Roswitha Tönnesmann, Jos Eersels, Philipp T Meyer, Helmut R Maecke, Svetlana N Rylova

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170435 (2017)

GLP-1 receptors are ideal targets for preoperative imaging of benign insulinoma and for quantifying the beta cell mass. The existing clinical tracers targeting GLP-1R are all agonists with low specific activity and very high kidney uptake. In order t

Externí odkaz: https://doaj.org/article/ef62f5584b584fdda76a5318d677e015

The tetraamine chelator outperforms HYNIC in a new technetium-99m-labelled somatostatin receptor 2 antagonist

Autor: Guillaume Nicolas, Jean Claude Reubi, Melpomeni Fani, Svetlana N. Rylova, Maria Luisa Tamma, Keelara Abiraj, Beatrice Waser, Edwin C. Constable, Samer Ursillo, Helmut R. Maecke

Publikováno v: Abiraj, Keelara; Ursillo, Samer; Tamma, Maria Luisa; Rylova, Svetlana N; Waser, Beatrice; Constable, Edwin C; Fani, Melpomeni; Nicolas, Guillaume P; Reubi, Jean Claude; Maecke, Helmut R (2018). The tetraamine chelator outperforms HYNIC in a new technetium-99m-labelled somatostatin receptor 2 antagonist. EJNMMI research, 8(1), p. 75. Springer 10.1186/s13550-018-0428-y
EJNMMI Research, Vol 8, Iss 1, Pp 1-10 (2018)
EJNMMI Research

Background Somatostatin receptor targeting radiopeptides are successfully being used to image, stage, and monitor patients with neuroendocrine tumours. They are exclusively agonists that internalise upon binding to the relevant receptor. According to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee5ab9356d78fb7403f95f4436146d7
https://boris.unibe.ch/122018/1/s13550-018-0428-y.pdf

Immuno-PET Imaging of CD30-Positive Lymphoma Using 89Zr-Desferrioxamine–Labeled CD30-Specific AC-10 Antibody

Autor: Anna Lena Illert, Roswitha Tönnesmann, Cathrin Klingeberg, Philipp T. Meyer, Jason P. Holland, Helmut R. Maecke, Svetlana N. Rylova, Luigi Del Pozzo

Publikováno v: Journal of Nuclear Medicine. 57:96-102

The CD30-specific antibody–drug conjugate, brentuximab vedotin, is approved for the treatment of relapsed, refractory Hodgkin lymphomas and systemic anaplastic large T-cell lymphomas. Multiple ongoing clinical trials are investigating brentuximab v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a715e065158b673faac6b267f11fdb
https://doi.org/10.2967/jnumed.115.162735

Radioiodinated Exendin-4 Is Superior to the Radiometal-Labelled Glucagon-Like Peptide-1 Receptor Probes Overcoming Their High Kidney Uptake

Autor: Roswitha Tönnesmann, Jos Eersels, Philipp T. Meyer, Helmut R. Maecke, Tilman Läppchen, Svetlana N. Rylova

Publikováno v: PLoS ONE
Läppchen, Tilman; Tönnesmann, Roswitha; Eersels, Jos; Meyer, Philipp T; Maecke, Helmut R; Rylova, Svetlana N (2017). Radioiodinated Exendin-4 Is Superior to the Radiometal-Labelled Glucagon-Like Peptide-1 Receptor Probes Overcoming Their High Kidney Uptake. PLoS ONE, 12(1), e0170435. Public Library of Science 10.1371/journal.pone.0170435
PLoS ONE, 12(1):e0170435. Public Library of Science
Läppchen, T, Tönnesmann, R, Eersels, J, Meyer, P T, Maecke, H R & Rylova, S N 2017, ' Radioiodinated exendin-4 is superior to the radiometal-labelled glucagon-like peptide-1 receptor probes overcoming their high kidney uptake ', PLoS ONE, vol. 12, no. 1, e0170435 . https://doi.org/10.1371/journal.pone.0170435
PLoS ONE, Vol 12, Iss 1, p e0170435 (2017)

GLP-1 receptors are ideal targets for preoperative imaging of benign insulinoma and for quantifying the beta cell mass. The existing clinical tracers targeting GLP-1R are all agonists with low specific activity and very high kidney uptake. In order t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaffcd332e564b3835096540c66329e6
https://pubmed.ncbi.nlm.nih.gov/28103285

The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration

Autor: John C. Chappell, Jessica Y. Heinz, Amanda L. Anderson, William P. Dunworth, Stephanie Kiser, Victoria L. Bautch, Andrew T. Barber, David M. Roberts, Paramjeet K. Randhawa, Joanna H. Fried, Svetlana N. Rylova

Publikováno v: Circulation research. 108(10)

Rationale: Fetuses that develop in diabetic mothers have a higher incidence of birth defects that include cardiovascular defects, but the signaling pathways that mediate these developmental effects are poorly understood. It is reasonable to hypothesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e813d55adb8c076e238e158380c6aa
https://pubmed.ncbi.nlm.nih.gov/21474816