Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Svetlana Marukian"'
Autor:
Nadine Daou, Andreu Viader, Murat Cokol, Arianna Nitzel, Manu V. Chakravarthy, Raffi Afeyan, Tony Tramontin, Svetlana Marukian, Michael J. Hamill
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Nonalcoholic steatohepatitis (NASH) is a complex metabolic disease of heterogeneous and multifactorial pathogenesis that may benefit from coordinated multitargeted interventions. Endogenous metabolic modulators (EMMs) encompass a broad set o
Externí odkaz:
https://doaj.org/article/c2f374aab92a482f9c189e152af4110d
Autor:
Goar Mosoyan, Chandandeep Nagi, Svetlana Marukian, Avelino Teixeira, Anait Simonian, Lois Resnick-Silverman, Analisa DiFeo, Dean Johnston, Sandra R Reynolds, Daniel F Roses, Arevik Mosoian
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55145 (2013)
BACKGROUND: Breast cancer cell lines are widely used tools to investigate breast cancer biology and to develop new therapies. Breast cancer tissue contains molecularly heterogeneous cell populations. Thus, it is important to understand which cell lin
Externí odkaz:
https://doaj.org/article/68c9f5a945c148a0a85f54b474247930
Autor:
Svetlana Marukian, Michael Hamill, Tony Tramontin, Murat Cokol, Arianna Nitzel, Manu V. Chakravarthy, Raffi Afeyan, Daou Nadine, Andreu Viader
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Nonalcoholic steatohepatitis (NASH) is a complex metabolic disease of heterogeneous and multifactorial pathogenesis that may benefit from coordinated multitargeted interventions. Endogenous metabolic modulators (EMMs) encompass a broad set of molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08635b467e1ffe258aeea39e8c43667
https://doi.org/10.1038/s41598-021-88913-1
https://doi.org/10.1038/s41598-021-88913-1
Autor:
Svetlana Marukian, Volodymyr Nechyporuk-Zloy, Charles M. Rice, Lynn B. Dustin, Stephen M. Laidlaw, Rachel H. Gilmore, Siobhán B. Cashman
Background & Aims Tumor necrosis factor (TNF) is an inflammatory cytokine expressed by human fetal liver cells (HFLCs) after infection with cell culture–derived hepatitis C virus (HCV). TNF has been reported to increase entry of HCV pseudoparticles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c10feae59855341436183e7da6a26e
https://europepmc.org/articles/PMC5627365/
https://europepmc.org/articles/PMC5627365/
Autor:
Brian R. Wamhoff, Arun J. Sanyal, Banumathi K. Cole, Ajit Dash, Stephen A. Hoang, Brett R. Blackman, Ryan E. Feaver, Svetlana Marukian, Mark J. Lawson, Robert A. Figler
Publikováno v:
JCI Insight. 1
A barrier to drug development for nonalcoholic steatohepatitis (NASH) is the absence of translational preclinical human-relevant systems. An in vitro liver model was engineered to incorporate hepatic sinusoidal flow, transport, and lipotoxic stress r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f79ab9cf50aded0d484894f7230336
https://doi.org/10.1172/jci.insight.90954
https://doi.org/10.1172/jci.insight.90954
Autor:
Michael Hamill, Sean M. Carroll, Murat Cokol, Tony Tramontin, Andrew Downey, Revati Wani, Arianna Nitzel, Svetlana Marukian, Raffi Afeyan, Russell Matthew, Zoe Steuert
Publikováno v:
Blood. 134:978-978
Background: In sickle cell disease (SCD), red blood cell (RBC) sickling propagates hemolysis, inflammation, vascular and endothelial injury with associated disruption in metabolic pathways including nitric oxide depletion, oxidative stress and an inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::214e6e3503348e8bf1dff79f15228b23
https://doi.org/10.1182/blood-2019-124224
https://doi.org/10.1182/blood-2019-124224
Autor:
Eiko Nishiuchi, Charles M. Rice, Svetlana Marukian, Michael I. M. Orloff, Edgar D. Charles, Lynn B. Dustin
Publikováno v:
Arthritis & Rheumatism. 65:2430-2440
Objective Hepatitis C virus (HCV) is the most frequent cause of mixed cryoglobulinemia (MC), which is characterized by endothelial deposition of rheumatoid factor (RF)–containing immune complexes and end-organ vasculitis. MC is a lymphoproliferativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::398d39bed006f7ba8e4d9ff257455f93
https://doi.org/10.1002/art.38041
https://doi.org/10.1002/art.38041
Autor:
Lynn B. Dustin, Charles M. Rice, Svetlana Marukian, Mohsan Saeed, Jens Bukh, Judith M. Gottwein, Troels K. H. Scheel
Despite recent advances in the treatment of hepatitis C, the quest for pan-genotype, effective, and well-tolerated inhibitors continues. To facilitate these efforts, it is desirable to have in vitro replication systems for all major HCV genotypes. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad310d047a162893446bc3f00d32ded
https://doi.org/10.1128/aac.01256-12
https://doi.org/10.1128/aac.01256-12
Autor:
Ajit Dash, Charles W. Qualls, Mark J. Lawson, Svetlana Marukian, David Manka, Ylva Terelius, Maria Sol Collado, Robert A. Figler, Aaron J. Mackey, Brian R. Wamhoff, Brett R. Blackman
Drug induced liver injury (DILI), a major cause of pre- and post-approval failure, is challenging to predict pre-clinically. Predicting DILI is challenging due to varied underlying direct and indirect mechanisms. Nevirapine, a non-nucleoside reverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8202ea43558212274cac919cd7533d
https://europepmc.org/articles/PMC4889565/
https://europepmc.org/articles/PMC4889565/
Autor:
Edgar D. Charles, Lynn B. Dustin, Kristen M. Marks, Kimberly D. Ritola, Charles M. Rice, Andrew H. Talal, Claudia Brunetti, Ira M. Jacobson, Svetlana Marukian
Publikováno v:
Blood. 117:5425-5437
Hepatitis C virus (HCV) is associated with the B-cell lymphoproliferative disorders mixed cryoglobulinemia (MC) and non-Hodgkin lymphoma. We have previously reported that HCV+MC+ patients have clonal expansions of hypermutated, rheumatoid factor–be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f2f3946107fc1fa81dd175d231f8d2
https://doi.org/10.1182/blood-2010-10-312942
https://doi.org/10.1182/blood-2010-10-312942