Heparin/heparan sulfates bind to and modulate neuronal L-type (Cav1.2) voltage-dependent Ca(2+) channels

Autor: Alexander Dityatev, Martin Heine, Gianpiero Garau, Paola Magotti, Patricia Marie-Jeanne Lievens, Svetlana Korotchenko, Vladimir Berezin

Publikováno v: Experimental neurology 274(Pt B), 156-165 (2015). doi:10.1016/j.expneurol.2015.08.006
Experimental Neurology

Our previous studies revealed that L-type voltage-dependent Ca(2+) channels (Cav1.2 L-VDCCs) are modulated by the neural extracellular matrix backbone, polyanionic glycan hyaluronic acid. Here we used isothermal titration calorimetry and screened a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605dc340222484e49e4f0b0d7e211581
https://pubmed.ncbi.nlm.nih.gov/26272754

Zooming in on the (peri)synaptic extracellular matrix

Autor: Alberto Diaspro, Francesca Cella Zanacchi, Alexander Dityatev, Svetlana Korotchenko

Publikováno v: Neuromethods ISBN: 9781461491781
New York, NY : Springer New York, Neuromethods 84, 187-203 (2014). doi:10.1007/978-1-4614-9179-8_10
Nanoscale Imaging of Synapses / Nägerl, U. Valentin (Editor) ; New York, NY : Springer New York, 2014, Chapter 10 ; ISSN: 0893-2336=1940-6045 ; ISBN: 978-1-4614-9178-1=978-1-4614-9179-8 ; doi:10.1007/978-1-4614-9179-8

Neurons and glial cells secrete numerous molecules that accumulate in the extracellular space and form the neural extracellular matrix (ECM). There are diverse forms of the ECM. The most conspicuous aggregates of ECM molecules, containing chondroitin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c547f129c0dc4ffa38f4be86e9a9f19
http://hdl.handle.net/11568/1080570

Modulation of network activity and induction of homeostatic synaptic plasticity by enzymatic removal of heparan sulfates

Autor: Luca Leonardo Bologna, Tatiana Kuznetsova, Svetlana Korotchenko, Michela Chiappalone, Alexander Dityatev, Lorenzo A. Cingolani

Publikováno v: Philosophical transactions / B 369(1654), 20140134 (2014). doi:10.1098/rstb.2014.0134

Heparan sulfates (HSs) are complex and highly active molecules that are required for synaptogenesis and long-term potentiation. A deficit in HSs leads to autistic phenotype in mice. Here, we investigated the long-term effect of heparinase I, which di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9a2c75b221c6bac8a1607ec222cdd1
https://doi.org/10.1098/rstb.2014.0134

Brain Extracellular Matrix in Health and Disease

Autor: Alexander Dityatev, Bernhard Wehrle-Haller, Asla Pitkänen

In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasmin