Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Svetlana Gaponova"'
Autor:
Yaroslav Staroseletz, Svetlana Gaponova, Olga Patutina, Elena Bichenkova, Bahareh Amirloo, Thomas Heyman, Daria Chiglintseva, Marina Zenkova
Publikováno v:
Molecules, Vol 26, Iss 6, p 1732 (2021)
RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are curren
Externí odkaz:
https://doaj.org/article/b6e2f145e1c94415a4b34c09e00a009c
Autor:
Olga Patutina, Daria Chiglintseva, Elena Bichenkova, Svetlana Gaponova, Nadezhda Mironova, Valentin Vlassov, Marina Zenkova
Publikováno v:
Molecules, Vol 25, Iss 10, p 2459 (2020)
Irreversible destruction of disease-associated regulatory RNA sequences offers exciting opportunities for safe and powerful therapeutic interventions against human pathophysiology. In 2017, for the first time we introduced miRNAses–miRNA-targeted c
Externí odkaz:
https://doaj.org/article/541a1ba4d2404fb3bbf78b1f9a1ee7a8
Autor:
Olga Patutina, Daria Chiglintseva, Bahareh Amirloo, David Clarke, Svetlana Gaponova, Valentin Vlassov, Elena Bichenkova, Marina Zenkova
Publikováno v:
Patutina, O A, Chiglintseva, D, Amirloo, B, Clarke, D, Gaponova, S, Vlassov, V V, Bichenkova, E & Zenkova, M 2022, ' Bulge-Forming miRNases Cleave Oncogenic miRNAs at the Central Loop Region in a Sequence-Specific Manner. ', International Journal of Molecular Sciences, vol. 23, no. 12, 6562, pp. 1-22 . https://doi.org/10.3390/ijms23126562
International Journal of Molecular Sciences; Volume 23; Issue 12; Pages: 6562
International Journal of Molecular Sciences; Volume 23; Issue 12; Pages: 6562
The selective degradation of disease-associated microRNA is promising for the development of new therapeutic approaches. In this study, we engineered a series of bulge-loop-forming oligonucleotides conjugated with catalytic peptide [(LeuArg)2Gly]2 (B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9cce90f54181a6d2b2c9a131d7eca2
https://doi.org/10.3390/ijms23126562
https://doi.org/10.3390/ijms23126562
Autor:
Mattew J. A. Wood, Mikhail A. Maslov, Marina A. Zenkova, Aleksandra V Sen'kova, Svetlana Gaponova, Innokenty A. Savin, Daniil V. Gladkikh, Ekaterine A. Burakova, A. A. Fokina, Elena V. Shmendel, O. A. Patutina, Dmitry A. Stetsenko, Valentin V. Vlassov, Sidney Altman
Publikováno v:
Proc Natl Acad Sci U S A
The design of modified oligonucleotides that combine in one molecule several therapeutically beneficial properties still poses a major challenge. Recently a new type of modified mesyl phosphoramidate (or µ-) oligonucleotide was described that demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8c42f783734c2f7c469e585dccc14e
https://doi.org/10.1073/pnas.2016158117
https://doi.org/10.1073/pnas.2016158117
Autor:
Svetlana Gaponova, Olga Patutina, Aleksandra Sen’kova, Ekaterina Burakova, Innokenty Savin, Andrey Markov, Elena Shmendel, Mikhail Maslov, Dmitry Stetsenko, Valentin Vlassov, Marina Zenkova
Publikováno v:
Cancers; Volume 14; Issue 18; Pages: 4396
Rational combinations of sequence-specific inhibitors of pro-oncogenic miRNAs can efficiently interfere with specific tumor survival pathways, offering great promise for targeted therapy of oncological diseases. Herein, we uncovered the potential of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1dacbd2b0ccb9ec5ac3cec8f877c41
https://doi.org/10.3390/cancers14184396
https://doi.org/10.3390/cancers14184396
Autor:
Svetlana Gaponova, O. A. Patutina, Daria Chiglintseva, Thomas Heyman, Yaroslav Staroseletz, Bahareh Amirloo, Elena V. Bichenkova, Marina A. Zenkova
Publikováno v:
Molecules
Staroseletz, Y, Gaponova, S, Patutina, O, Bichenkova, E, Amirloo, B, Heyman, T, Chiglintseva, D & Zenkova, M 2021, ' Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences ', Molecules, vol. 26, no. 6, 1732 . https://doi.org/10.3390/molecules26061732
Molecules, Vol 26, Iss 1732, p 1732 (2021)
Staroseletz, Y, Gaponova, S, Patutina, O, Bichenkova, E, Amirloo, B, Heyman, T, Chiglintseva, D & Zenkova, M 2021, ' Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences ', Molecules, vol. 26, no. 6, 1732 . https://doi.org/10.3390/molecules26061732
Molecules, Vol 26, Iss 1732, p 1732 (2021)
RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded082a5998cbe2cfe9d63e630771df5
https://doi.org/10.3390/molecules26061732
https://doi.org/10.3390/molecules26061732