Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Svetlana Frank"'
Autor:
Berno Dankbar, Thomas Pap, Svetlana Frank, Olli A Jänne, Daniel Umlauf, David J. J. de Gorter
Publikováno v:
New players and novel targets in inflammation.
Background Rheumatoid arthritis is a common autoimmune disease characterised by the hyperplastic transformation of synovium, its infiltration with γ inflammatory cells and by stimulation of bone resorption through osteoclast activation leading to jo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cfdd8a1b7db0d68d2549a80506be0f6
https://doi.org/10.1136/annrheumdis-2016-211050.14
https://doi.org/10.1136/annrheumdis-2016-211050.14
Autor:
Svetlana Frank, Marvin A Peters, Corinna Wehmeyer, Simon Strietholt, Christina Koers-Wunrau, Jessica Bertrand, Marianne Heitzmann, Anja Hillmann, Joanna Sherwood, Christine Seyfert, Steffen Gay, Thomas Pap
Publikováno v:
Annals of the Rheumatic Diseases. 72:1874-1881
Objective Based on previous data that have linked the small ubiquitin-like modifier-1 (SUMO-1) to the pathogenesis of rheumatoid arthritis (RA), we have investigated the expression of the highly homologous SUMO family members SUMO-2/3 in human RA and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b0ae401269c9c18e848136ec184e87
https://doi.org/10.1136/annrheumdis-2012-202080
https://doi.org/10.1136/annrheumdis-2012-202080
Autor:
Ina Kramer, Michelle Fennen, Denise Beckmann, Athanasios Stratis, Svetlana Frank, Corinna Wehmeyer, Thomas Kamradt, Thomas Pap, U König, Michaela Kneissel, Berno Dankbar, Peter Paruzel, Adelheid Korb-Pap, Annelena Held, Christine Hartmann, C Cromme, Martin Böttcher, Wim B. van den Berg
Publikováno v:
Science Translational Medicine, 8, 330ra35-330ra35
Science Translational Medicine, 8, 330, pp. 330ra35-330ra35
Science Translational Medicine, 8, 330, pp. 330ra35-330ra35
Item does not contain fulltext Sclerostin, an inhibitor of the Wnt/beta-catenin pathway, has anti-anabolic effects on bone formation by negatively regulating osteoblast differentiation. Mutations in the human sclerostin gene (SOST) lead to sclerosteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2cb601ee469ac657bffbaaf1a018f9
http://hdl.handle.net/2066/171465
http://hdl.handle.net/2066/171465
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 42:1594-1601
Osteoarthritis (OA) is a degenerative joint disease that is characterized primarily by progressive breakdown of articular cartilage. The loss of proteoglycans, the mineralization of the extracellular matrix (ECM) and the hypertrophic differentiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7a67d9293cfe66cb64333c6cf03624
https://doi.org/10.1016/j.biocel.2010.06.022
https://doi.org/10.1016/j.biocel.2010.06.022
Publikováno v:
Cellular and Molecular Life Sciences. 67:4197-4211
Osteoarthritis is one of the most common forms of musculoskeletal disease and the most prominent type of arthritis encountered in all countries. Although great efforts have been made to investigate cartilage biology and osteoarthritis pathology, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5727db75e76474385b0a6f1b7caeef0a
https://doi.org/10.1007/s00018-010-0498-0
https://doi.org/10.1007/s00018-010-0498-0
Autor:
Jessica Bertrand, Thomas Pap, Adelheid Korb-Pap, Peter Paruzel, Daniela Brunert, Svetlana Frank, Kurt Redlich, Denise Beckmann, Berno Dankbar, Corinna Wehmeyer, Silvia Hayer, Athanasios Stratis, Michelle Fennen, Christina Koers-Wunrau
Publikováno v:
Nature medicine. 21(9)
Myostatin is shown to directly promote osteoclast differentiation, and its inhibition improves arthritic bone loss in two mouse models. Myostatin (also known as growth and differentiation factor 8) is a secreted member of the transforming growth fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89599289a488d85c24177d8870f55ee3
https://pubmed.ncbi.nlm.nih.gov/26388227
https://pubmed.ncbi.nlm.nih.gov/26388227
Autor:
Albrecht Schwab, Otto Lindemann, Sandra Schimmelpfennig, Alexander Dietrich, Svetlana Frank, Thomas Pap, Jessica Bertrand, Peter J. Hanley, Anke Fabian, Daniel Umlauf
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 190(11)
Unraveling the mechanisms involved in chemotactic navigation of immune cells is of particular interest for the development of new immunoregulatory therapies. It is generally agreed upon that members of the classical transient receptor potential chann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc45dc0d46836dbcd4ed3964004e68a
https://pubmed.ncbi.nlm.nih.gov/23636057
https://pubmed.ncbi.nlm.nih.gov/23636057
Autor:
Denise Beckmann, U König, Peter Paruzel, C Cromme, Annelena Held, Adelheid Korb-Pap, Ina Kramer, Martin Böttcher, Michelle Fennen, Thomas Pap, Michaela Kneissel, Christine Hartmann, W.B. van den Berg, Corinna Wehmeyer, Svetlana Frank, Athanasios Stratis, Thomas Kamradt, Berno Dankbar
Publikováno v:
Annals of the Rheumatic Diseases. 75:A78.1-A78
Background and objectives Wnt-inhibitor sclerostin has anti-anabolic effects on bone formation by negatively regulating osteoblast differentiation. Loss of sclerostin expression results in high bone mass and bone strength in patients with sclerosteos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c68e28ed0df936269b5a1627498048b2
https://doi.org/10.1136/annrheumdis-2016-209124.186
https://doi.org/10.1136/annrheumdis-2016-209124.186
Autor:
Beate Eckes, Svetlana Frank, Doreen Wendholt, Wim B. van den Berg, Simon Strietholt, Adelheid Korb-Pap, Noreen Pundt, Leo A. B. Joosten, Marvin A. Peters, Thomas Pap, George Kollias
Publikováno v:
Arthritis and Rheumatism, 64, 1359-68
Arthritis and Rheumatism, 64, 5, pp. 1359-68
Arthritis and Rheumatism, 64, 5, pp. 1359-68
Item does not contain fulltext OBJECTIVE: Integrin alpha2beta1 functions as a major receptor for type I collagen on different cell types, including fibroblasts and inflammatory cells. Although in vitro data suggest a role for alpha2beta1 integrin in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f13eb77271bcb04197bc107c6c7a78a
https://www.ncbi.nlm.nih.gov/pubmed/22083543
https://www.ncbi.nlm.nih.gov/pubmed/22083543
Autor:
Thomas Pap, Marvin A. Peters, D Wendholt, Svetlana Frank, George Kollias, Adelheid Korb, B Eckes, Simon Strietholt
Publikováno v:
Annals of the Rheumatic Diseases. 69:A22-A23
Integrins are the main receptors for cell-matrix interactions and integrin signalling is critical for a variety of cellular functions such as adhesion, cell spreading and inflammatory responses. α2β1 integrin functions as a major receptor for type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c36df93f26de56a16e4b2a340eb49d6
https://doi.org/10.1136/ard.2010.129593r
https://doi.org/10.1136/ard.2010.129593r