Phase I clinical trial evaluating the safety and efficacy of ADP-A2M10 SPEAR T cells in patients with MAGE-A10+ advanced non-small cell lung cancer

Autor: Victor Moreno, Andrew Gerry, Tom Holdich, Anthony J Olszanski, Ramaswamy Govindan, John V Heymach, Matthew J Frigault, Siddhartha Devarakonda, Melissa Johnson, Justin Gainor, Carlos Bachier, Natalie Hyland, Jean-Marc Navenot, Svetlana Fayngerts, Jane Bai, Elliot Norry, Robyn Broad, George R Blumenschein, Martin J Edelman, Bernard Doger de Spéville, Vincent K Lam, Zohar Wolchinsky, Dzmitry Batrakou, Melissa M Pentony, Joseph P Sanderson, Diane Marks, Paula M Fracasso

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)

Externí odkaz: https://doaj.org/article/bb48deb4a4b44ce99c7898cce61aa878

285 Phase I clinical trial evaluating the safety of ADP-A2M10 in patients with MAGE-A10+ head and neck, melanoma, or urothelial tumors

Autor: Marcus Butler, David Hong, Ryan Sullivan, Matthew Frigault, Sarah Boross-Harmer, Ecaterina Dumbrava, Jean-Marc Navenot, Svetlana Fayngerts, Jane Bai, Elliot Norry, Paula Fracasso, Russell Pachynski, Partow Kebriaei, Amy Sauer, Francine Brophy

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Externí odkaz: https://doaj.org/article/3cc3704b6a2e45a5bc9da899afd13797

Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma

Autor: Gwendolyn K. Binder, Dejka M. Araujo, Daniel Nunez, Samik Basu, Luca Melchiori, Rafael G. Amado, Gareth Betts, Natalie Bath, Rebecca Dryer-Minnerly, Ruoxi Wang, Sandra P. D'Angelo, Mihaela Druta, Malini Iyengar, Albiruni Ryan Abdul Razak, Stephan A. Grupp, Breelyn A. Wilky, Jean Marc Navenot, George D. Demetri, Alex Tipping, Brian A. Van Tine, Erin Van Winkle, Warren Chow, Trupti Trivedi, Indu R. Ramachandran, Svetlana Fayngerts, Karen Chagin, Crystal L. Mackall, Daniel E. Lowther, John Glod

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-14 (2019)
Journal for immunotherapy of cancer, vol 7, iss 1
Journal for Immunotherapy of Cancer

Background Gene-modified autologous T cells expressing NY-ESO-1c259, an affinity-enhanced T-cell receptor (TCR) reactive against the NY-ESO-1-specific HLA-A*02-restricted peptide SLLMWITQC (NY-ESO-1 SPEAR T-cells; GSK 794), have demonstrated clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c648dd5bd91ef16d6fab900e2b046d4
http://link.springer.com/article/10.1186/s40425-019-0762-2

Directing leukocyte polarization and migration by the phosphoinositide transfer protein TIPE2

Autor: Mei Lin, Youhai H. Chen, Svetlana Fayngerts, Thomas Porturas, Honghong Sun, Weidong Xie, Terry Cathopoulis, Ali Zamani, Jason R. Goldsmith, Anastassios Vourekas, Amanda E. Boggs, Zhaojun Wang

Publikováno v: Nature immunology

The polarization of leukocytes toward chemoattractants is essential for the directed migration (chemotaxis) of leukocytes. How leukocytes acquire polarity after encountering chemical gradients is not well understood. We found here that leukocyte pola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d5e225957ff2d5003e494c09d99ed3
http://europepmc.org/articles/PMC5690821

Data from the third dose cohort of an ongoing study with ADP-A2AFP SPEAR T cells

Autor: Bruno Sangro, Mitesh J. Borad, Petr F. Hausner, Tim Meyer, Amit Mahipal, Lipika Goyal, Matthew J. Frigault, Debashis Sarker, Lynn G. Feun, Kit Wong, Anthony El-Khoureiry, Richard Finn, Ahmed Kaseb, Benjamin R. Tan, Fiona Thistlethwaite, Bassel El-Rayes, Jordi Bruix, Joana Senra, Trupti Trivedi, Paula Fracasso, Svetlana Fayngerts, Erica Elefant, Jennifer Sampson, Swethajit Biswas, Elliot Norry

Publikováno v: Journal of Hepatology. 73:S122

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65ccc4fb679d1de8906fb616eb9f9c11
https://doi.org/10.1016/s0168-8278(20)30761-3